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AEC syndrome mouse model p63 protein aggregation Skin Animals Cleft Lip Cleft Palate Ectoderm Eye Abnormalities Frameshift Mutation HEK293 Cells Heterozygote Humans Mice Mutation Mutation Missense Phosphoproteins Protein Binding Protein Denaturation Skin Trans-Activators Transcription Factors Transcription Genetic Tumor Suppressor Proteins

When combined with NMR spectroscopy, high hydrostatic pressure is an alternative perturbation method used to destabilize globular proteins that has proven to be particularly well suited for exploring the unfolding energy...

NMR high hydrostatic pressure Protein Folding Thermodynamic stability α-helical bundle Adaptor Proteins Signal Transducing Humans Kinetics Magnetic Resonance Spectroscopy Models Molecular Protein Conformation Protein Conformation alpha-Helical Protein Denaturation Protein Domains Protein Unfolding Temperature Thermodynamics

Sensory rhodopsin II (pSRII), a retinal-binding photophobic receptor from Natronomonas pharaonis, is a novel model system for membrane protein folding studies. Recently, the SDS-denatured states and the kinetics for reversible...

Backbone amides Chemical shifts Folding Membrane Proteins Transmembrane helices Halobacteriaceae Models Molecular Nuclear Magnetic Resonance Biomolecular Protein Denaturation Protein Folding Protein Structure Secondary Protein Structure Tertiary Sensory Rhodopsins Sodium Dodecyl Sulfate

Adult Antibody Specificity Complement Activation Complement C1q Female Graft Rejection Graft Survival HLA Antigens Histocompatibility Histocompatibility Testing Humans Immunoglobulin G Isoantibodies Male Middle Aged Predictive Value of Tests Protein Binding Protein Denaturation Protein Folding Reproducibility of Results Young Adult

There are very few generic methods to assess the stability and functional properties of membrane proteins solubilized in detergent. For this purpose, a thiol-reactive fluorochrome...

CPM thermostability Membrane Proteins Proteins Adenomatous Polyposis Coli Protein Bacteria Coumarins detergents Fluorescent Dyes Humans Membrane Proteins Protein Denaturation Protein Stability Temperature

Folding Kinetics Membrane Proteins retinal Animals Bacteriorhodopsins Cattle Kinetics Protein Binding Protein Conformation Protein Denaturation Protein Folding Protein Refolding Protein Structure Tertiary Protein Unfolding Sensory Rhodopsins Solvents

Many rare and valuable ancient specimens now carry the scars of ancient DNA research, as questions of population genetics and phylogeography require larger sample sets. This fuels the demand for reliable techniques to screen for...

Amino Acids Animals Archaeology Bison Bone and Bones DNA Paleontology Protein Denaturation

The biophysical stability is an important parameter for protein activity both in vivo and in vitro. Here we propose a method to analyse thermal melting of protein domains in lysates: Fast parallel proteolysis (FASTpp). Combining...

Aminoacyltransferases Bacterial Proteins Biophysical Phenomena Chemistry Techniques Analytical Cysteine Endopeptidases Cytochromes c Electrophoresis Polyacrylamide Gel Heme Kinetics Maltose Maltose-Binding Proteins Point Mutation Protein Binding Protein Denaturation Protein Folding Protein Stability Protein Structure Tertiary Protein Unfolding Proteins Proteolysis Reproducibility of Results Temperature Thermolysin

IDP Cooperativity parallel pathways Protein Engineering Protein Folding Bacterial Proteins Intrinsically Disordered Proteins Kinetics Membrane Proteins Models Molecular Protein Conformation Protein Denaturation Protein Domains Protein Folding Protein Stability Protein Unfolding

Algorithms Amino Acid Sequence Amino Acid Substitution Amino Acids Computer Simulation Databases Protein evolution Molecular Hydrophobic and Hydrophilic Interactions Likelihood Functions Models Biological Mutation Protein Denaturation Protein Folding Proteins Structure-Activity Relationship Thermodynamics

Consensus-designed tetratricopeptide repeat proteins are highly stable, modular proteins that are strikingly amenable to rational engineering. They therefore have tremendous potential as building blocks for biomaterials and...

Amino Acid Motifs Amino Acid Sequence Models Molecular Protein Denaturation Protein Stability Proteins Repetitive Sequences Amino Acid Thermodynamics

folding intermediate folding pathway knotted protein partially unfolded form ubiquitin C-terminal hydrolase Deuterium Deuterium Exchange Measurement Humans Hydrogen Hydrogen-Ion Concentration Kinetics Magnetic Resonance Spectroscopy Protein Conformation alpha-Helical Protein Conformation beta-Strand Protein Denaturation Protein Folding Ubiquitin Thiolesterase