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Structural Characterization of Covalently Stabilized Human Cystatin C Oligomers.
Magdalena Chrabąszczewska, Adam K Sieradzan, Sylwia Rodziewicz-Motowidło, Anders Grubb, Christopher M Dobson, Janet R Kumita, Maciej Kozak
Aug 14, 2020
Trodusquemine displaces protein misfolded oligomers from cell membranes and abrogates their cytotoxicity through a generic mechanism.
Ryan Limbocker, Benedetta Mannini, Francesco S Ruggeri, Roberta Cascella, Catherine K Xu, Michele Perni, Sean Chia, Serene W Chen, Johnny Habchi, Alessandra Bigi, Ryan P Kreiser, Aidan K Wright, J Alex Albright, Tadas Kartanas, Janet R Kumita, Nunilo Cremades, Michael Zasloff, Cristina Cecchi, Tuomas PJ Knowles, Fabrizio Chiti, Michele Vendruscolo, Christopher M Dobson
Sep 24, 2020
The onset and progression of numerous protein misfolding diseases are associated with the presence of oligomers formed during the aberrant aggregation of several different proteins, including amyloid-β (Aβ) in Alzheimer's...
Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats.
Broken chromosomes arising from DNA double-strand breaks result from endogenous events such as the production of reactive oxygen species during cellular metabolism, as well as from exogenous sources such as ionizing radiation....
Structural insight into mitochondrial β-barrel outer membrane protein biogenesis.
Kathryn A Diederichs, Xiaodan Ni, Sarah E Rollauer, Istvan Botos, Xiaofeng Tan, Martin S King, Edmund RS Kunji, Jiansen Jiang, Susan K Buchanan
Jul 03, 2020
In mitochondria, β-barrel outer membrane proteins mediate protein import, metabolite transport, lipid transport, and biogenesis. The Sorting and Assembly Machinery (SAM) complex consists of three proteins that assemble as a...
Amino Acid Sequence Cryoelectron Microscopy detergents Fungal Proteins Mitochondria Mitochondrial Membrane Transport Proteins Mitochondrial Membranes Multiprotein Complexes Protein Biosynthesis Protein Conformation Protein Folding Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Sequence Homology Amino Acid Sordariales
Accurate prediction of protein structures and interactions using a three-track neural network.
Minkyung Baek, Frank Dimaio, Ivan Anishchenko, Justas Dauparas, Sergey Ovchinnikov, Gyu Rie Lee, Jue Wang, Qian Cong, Lisa N Kinch, R Dustin Schaeffer, Claudia Millán, Hahnbeom Park, Carson Adams, Caleb R Glassman, Andy DeGiovanni, Jose H Pereira, Andria V Rodrigues, Alberdina A van Dijk, Ana C Ebrecht, Diederik J Opperman, Theo Sagmeister, Christoph Buhlheller, Tea Pavkov-Keller, Manoj K Rathinaswamy, Udit Dalwadi, Calvin K Yip, John E Burke, K Christopher Garcia, Nick V Grishin, Paul D Adams, Randy J Read, David Baker
Jul 16, 2021
DeepMind presented notably accurate predictions at the recent 14th Critical Assessment of Structure Prediction (CASP14) conference. We explored network architectures that incorporate related ideas and obtained the best...
ADAM Proteins Amino Acid Sequence Computer Simulation Cryoelectron Microscopy Crystallography X-Ray Databases Protein Deep learning Membrane Proteins Models Molecular Multiprotein Complexes Neural Networks Computer Protein Conformation Protein Folding Protein Subunits Proteins Receptors G-Protein-Coupled Sphingosine N-Acyltransferase
Structural and functional diversity calls for a new classification of ABC transporters.
Christoph Thomas, Stephen G Aller, Konstantinos Beis, Elisabeth P Carpenter, Geoffrey Chang, Lei Chen, Elie Dassa, Michael Dean, Franck Duong Van Hoa, Damian Ekiert, Robert Ford, Rachelle Gaudet, Xin Gong, I Barry Holland, Yihua Huang, Daniel K Kahne, Hiroaki Kato, Vassilis Koronakis, Christopher M Koth, Youngsook Lee, Oded Lewinson, Roland Lill, Enrico Martinoia, Satoshi Murakami, Heather W Pinkett, Bert Poolman, Daniel Rosenbaum, Balazs Sarkadi, Lutz Schmitt, Erwin Schneider, Yigong Shi, Show-Ling Shyng, Dirk J Slotboom, Emad Tajkhorshid, D Peter Tieleman, Kazumitsu Ueda, András Váradi, Po-Chao Wen, Nieng Yan, Peng Zhang, Hongjin Zheng, Jochen Zimmer, Robert Tampé
Oct 05, 2020
Members of the ATP-binding cassette (ABC) transporter superfamily translocate a broad spectrum of chemically diverse substrates. While their eponymous ATP-binding cassette in the nucleotide-binding domains (NBDs) is highly...