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lncRNA Spehd Regulates Hematopoietic Stem and Progenitor Cells and Is Required for Multilineage Differentiation.
M Joaquina Delás, Benjamin T Jackson, Tatjana Kovacevic, Silvia Vangelisti, Ester Munera Maravilla, Sophia A Wild, Eva Maria Stork, Nicolas Erard, Simon RV Knott, Gregory J Hannon
Apr 05, 2019
HSC Hematopoiesis lncRNA Oxidative Phosphorylation Animals Bone Marrow Transplantation Cell Differentiation Cell Line Tumor Cell Lineage Cyclin-Dependent Kinase 6 Female GATA2 Transcription Factor Hematopoiesis Hematopoietic Stem Cells Mice Mice Inbred C57BL Oxidative Phosphorylation Proto-Oncogene Proteins RNA Interference RNA Long Noncoding RNA Small Interfering Regeneration Trans-Activators
Activated Microglia Desialylate and Phagocytose Cells via Neuraminidase, Galectin-3, and Mer Tyrosine Kinase
TET2 Regulates the Neuroinflammatory Response in Microglia.
Alejandro Carrillo-Jimenez, Özgen Deniz, Maria Victoria Niklison-Chirou, Rocio Ruiz, Karina Bezerra-Salomão, Vassilis Stratoulias, Rachel Amouroux, Ping Kei Yip, Anna Vilalta, Mathilde Cheray, Alexander Michael Scott-Egerton, Eloy Rivas, Khadija Tayara, Irene García-Domínguez, Juan Garcia-Revilla, Juan Carlos Fernandez-Martin, Ana Maria Espinosa-Oliva, Xianli Shen, Peter St George-Hyslop, Guy Charles Brown, Petra Hajkova, Bertrand Joseph, Jose Luis Venero, Miguel Ramos Branco, Miguel Angel Burguillos
Oct 29, 2019
Epigenomic mechanisms regulate distinct aspects of the inflammatory response in immune cells. Despite the central role for microglia in neuroinflammation and neurodegeneration, little is known about their epigenomic regulation...
TET2 TLR-4 epigenetics metabolism Microglia Neuroinflammation Alzheimer Disease Amyloid Animals Brain DNA-Binding Proteins Dioxygenases Enhancer Elements Genetic Humans Interleukin-6 Lipopolysaccharides Male Mice Mice Inbred C57BL Mice Knockout Microglia Nitric Oxide Synthase Type II Proto-Oncogene Proteins RNA Interference RNA Small Interfering Rats Transcription Factor RelA Transcription Genetic
Insights into Coupled Folding and Binding Mechanisms from Kinetic Studies.
IDP biophysics coupled folding and binding Electrostatics Kinetics phi-value protein dynamic protein electrostatics Protein Folding protein-protein interactions residual structure signaling Apoptosis Regulatory Proteins CREB-Binding Protein Cyclic AMP Response Element-Binding Protein Humans Hydrophobic and Hydrophilic Interactions Intrinsically Disordered Proteins Kinetics Molecular Dynamics Simulation Myeloid Cell Leukemia Sequence 1 Protein Protein Binding Protein Folding Protein Interaction Domains and Motifs Proto-Oncogene Proteins Signal Transduction Static Electricity Thermodynamics
Multilocus Inherited Neoplasia Alleles Syndrome
James Whitworth, Anne-Bine Skytte, Lone Sunde, Derek H Lim, Mark J Arends, Lisa Happerfield, Ian M Frayling, Rick van Minkelen, Emma R Woodward, Marc D Tischkowitz, Eamonn R Maher
Mar 23, 2016
Drosophila astrocytes cover specific territories of the CNS neuropil and are instructed to differentiate by Prospero, a key effector of Notch.
Emilie Peco, Sejal Davla, Darius Camp, Stephanie M Stacey, Matthias Landgraf, Don J van Meyel
Apr 05, 2016
Astrocyte development Astroglial map Notch Pointed Prospero Animals Astrocytes Cell Lineage Central Nervous System DNA-Binding Proteins Drosophila Proteins Drosophila melanogaster Excitatory Amino Acid Transporter 1 Excitatory Amino Acid Transporter 2 Gene Expression Regulation Developmental Nerve Tissue Proteins Neurogenesis Neuroglia Neuropil Nuclear Proteins Proto-Oncogene Proteins RNA Interference RNA Small Interfering Receptors Notch Transcription Factors
Immune adaptor SKAP1 acts a scaffold for Polo-like kinase 1 (PLK1) for the optimal cell cycling of T-cells.
While the immune cell adaptor protein SKAP1 mediates LFA-1 activation induced by antigen-receptor (TCR/CD3) ligation on T-cells, it is unclear whether the adaptor interacts with other mediators of T-cell function. In this...
The DNA methylation landscape of the root-knot nematode-induced pseudo-organ, the gall, in Arabidopsis, is dynamic, contrasting over time, and critically important for successful parasitism.
Ana Cláudia Silva, Virginia Ruiz-Ferrer, Sebastian Y Müller, Clement Pellegrin, Patricia Abril-Urías, Ángela Martínez-Gómez, Almudena Gómez-Rojas, Eduardo Berenguer, Pilar S Testillano, Maria Fe Andrés, Carmen Fenoll, Sebastian Eves-van den Akker, Carolina Escobar
Sep 02, 2022
Root-knot nematodes (RKNs) induce giant cells (GCs) within galls which are characterized by large-scale gene repression at early stages. However, the epigenetic mechanism(s) underlying gene silencing is (are) still poorly...
Meloidogyne javanica Arabidopsis DNA methylation/epigenetics signatures galls Giant Cells siRNAs tomato transposons Animals Arabidopsis Protein-Tyrosine Kinases Gene Expression Regulation Plant DNA Methylation Plant Roots Proto-Oncogene Proteins Tylenchoidea Arabidopsis Proteins DNA (Cytosine-5-)-Methyltransferases
Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming.
Thomas Moreau, Amanda L Evans, Louella Vasquez, Marloes R Tijssen, Ying Yan, Matthew W Trotter, Daniel Howard, Maria Colzani, Meera Arumugam, Wing Han Wu, Amanda Dalby, Riina Lampela, Guenaelle Bouet, Catherine M Hobbs, Dean C Pask, Holly Payne, Tatyana Ponomaryov, Alexander Brill, Nicole Soranzo, Willem H Ouwehand, Roger A Pedersen, Cedric Ghevaert
Feb 09, 2016
Basic Helix-Loop-Helix Transcription Factors Blood Platelets Cell Culture Techniques Cell Differentiation Cell Proliferation Cellular Reprogramming Cryopreservation GATA1 Transcription Factor Gene Expression Regulation Genes Reporter Genetic Vectors Green Fluorescent Proteins Humans Lentivirus Megakaryocytes Microarray Analysis Pluripotent Stem Cells Proto-Oncogene Protein c-fli-1 Proto-Oncogene Proteins Signal Transduction T-Cell Acute Lymphocytic Leukemia Protein 1 Transduction Genetic Transgenes
Antitumor activity in RAS-driven tumors by blocking AKT and MEK.
Anthony W Tolcher, Khurum Khan, Michael Ong, Udai Banerji, Vassiliki Papadimitrakopoulou, David R Gandara, Amita Patnaik, Richard D Baird, David Olmos, Christopher R Garrett, Jeffrey M Skolnik, Eric H Rubin, Paul D Smith, Pearl Huang, Maria Learoyd, Keith A Shannon, Anne Morosky, Ernestina Tetteh, Ying-Ming Jou, Kyriakos P Papadopoulos, Victor Moreno, Brianne Kaiser, Timothy A Yap, Li Yan, Johann S de Bono
Mar 06, 2015
Adult Aged Aged 80 and over Animals Antineoplastic Combined Chemotherapy Protocols Benzimidazoles Cell Line Tumor Female Heterocyclic Compounds 3-Ring Humans MAP Kinase Kinase Kinases Male Mice Middle Aged Neoplasms Proto-Oncogene Proteins Proto-Oncogene Proteins c-akt Proto-Oncogene Proteins p21(ras) Xenograft Model Antitumor Assays ras Proteins
TET3 prevents terminal differentiation of adult NSCs by a non-catalytic action at Snrpn.
Raquel Montalbán-Loro, Anna Lozano-Ureña, Mitsuteru Ito, Christel Krueger, Wolf Reik, Anne C Ferguson-Smith, Sacri R Ferrón
Apr 12, 2019
Ten-eleven-translocation (TET) proteins catalyze DNA hydroxylation, playing an important role in demethylation of DNA in mammals. Remarkably, although hydroxymethylation levels are high in the mouse brain, the potential role of...
Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer.
Timothy J Humpton, Brinda Alagesan, Gina M DeNicola, Dan Lu, Georgi N Yordanov, Carl S Leonhardt, Melissa A Yao, Priya Alagesan, Maya N Zaatari, Youngkyu Park, Jeremy N Skepper, Kay F Macleod, Pedro A Perez-Mancera, Michael P Murphy, Gerard I Evan, Karen H Vousden, David A Tuveson
Oct 29, 2019
Animals Carcinoma Pancreatic Ductal Cell Line Tumor Gene Expression Regulation Neoplastic Glycolysis Humans Membrane Proteins Mice Mitochondria mitophagy Mutation NADP Neoplasm Transplantation Oxidation-Reduction Pancreatic Neoplasms Proto-Oncogene Proteins Proto-Oncogene Proteins p21(ras) Tumor Suppressor Proteins
Single-cell analyses of regulatory network perturbations using enhancer-targeting TALEs suggest novel roles for PU.1 during haematopoietic specification.
Adam C Wilkinson, Viviane KS Kawata, Judith Schütte, Xuefei Gao, Stella Antoniou, Claudia Baumann, Steven Woodhouse, Rebecca Hannah, Yosuke Tanaka, Gemma Swiers, Victoria Moignard, Jasmin Fisher, Shimauchi Hidetoshi, Marloes R Tijssen, Marella FTR de Bruijn, Pentao Liu, Berthold Göttgens
Sep 12, 2014
Haematopoiesis PU.1 Regulatory networks Transcription activator-like effectors Animals Cell Differentiation Coculture Techniques Endothelial Cells Gene Expression Profiling Gene Expression Regulation Developmental Hematopoiesis Hematopoietic Stem Cells Humans K562 Cells Mice Mice Transgenic Phenotype Proto-Oncogene Proteins Single-Cell Analysis Trans-Activators Transcription Factors Transgenes Xanthomonas
Sin3A recruits Tet1 to the PAH1 domain via a highly conserved Sin3-Interaction Domain.
The Sin3A complex acts as a transcriptional hub, integrating the function of diverse transcription factors with histone modifying enzymes, notably, histone deacetylases (HDAC) 1 and 2. The Sin3A protein sits at the centre of the...
Amino Acid Substitution DNA Mutational Analysis HEK293 Cells Humans Magnetic Resonance Spectroscopy Mixed Function Oxygenases Models Molecular Protein Binding Protein Conformation Protein Domains Protein Interaction Mapping Proto-Oncogene Proteins Repressor Proteins Sin3 Histone Deacetylase and Corepressor Complex
Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration.
Luigi Aloia, Mikel Alexander McKie, Grégoire Vernaz, Lucía Cordero-Espinoza, Niya Aleksieva, Jelle van den Ameele, Francesco Antonica, Berta Font-Cunill, Alexander Raven, Riccardo Aiese Cigliano, German Belenguer, Richard L Mort, Andrea H Brand, Magdalena Zernicka-Goetz, Stuart J Forbes, Eric A Miska, Meritxell Huch
Oct 21, 2019
Adaptor Proteins Signal Transducing Animals Bile Ducts Cell Cycle Proteins DNA Methylation DNA-Binding Proteins Epigenesis Genetic epigenome Epithelial Cells Female Gene Expression Profiling Hippo Signaling Pathway Liver Liver Regeneration Male Mice Transgenic Organoids Primary Cell Culture Protein Serine-Threonine Kinases Proto-Oncogene Proteins Signal Transduction Transcriptome YAP-Signaling Proteins
Open chromatin profiling identifies AP1 as a transcriptional regulator in oesophageal adenocarcinoma.
Edward Britton, Connor Rogerson, Shaveta Mehta, Yaoyong Li, Xiaodun Li, OCCAMS consortium, Rebecca C Fitzgerald, Yeng S Ang, Andrew D Sharrocks
Nov 01, 2018
Adenocarcinoma Adenovirus E1A Proteins Cell Line Tumor Chromatin Chromatin Assembly and Disassembly DNA-Binding Proteins Esophageal Neoplasms Gene Expression Regulation Neoplastic Gene Knockdown Techniques Humans Proto-Oncogene Proteins Proto-Oncogene Proteins c-ets Transcription Factor AP-1 Transcription Factors Transcriptional Activation
The WDR11 complex facilitates the tethering of AP-1-derived vesicles.
Paloma Navarro Negredo, James R Edgar, Paul T Manna, Robin Antrobus, Margaret S Robinson
Jul 20, 2018
Vesicluar transport of proteins from endosomes to the trans-Golgi network (TGN) is an essential cellular pathway, but much of its machinery is still unknown. A screen for genes involved in endosome-to-TGN trafficking produced...
Adaptor Protein Complex 1 Autoantigens CRISPR-Cas Systems Cytoplasmic Vesicles Endosomes GTPase-Activating Proteins HEK293 Cells HeLa Cells Humans Membrane Proteins Microscopy Fluorescence Multiprotein Complexes Protein Binding Protein Transport Proto-Oncogene Proteins RNA Interference trans-Golgi Network
The LMO2 -25 Region Harbours GATA2-Dependent Myeloid Enhancer and RUNX-Dependent T-Lymphoid Repressor Activity.
Adaptor Proteins Signal Transducing Animals Base Sequence Binding Sites Cell Line Cell Line Tumor Core Binding Factor alpha Subunits Enhancer Elements Genetic GATA2 Transcription Factor Gene Expression Regulation Hematopoiesis Humans Jurkat Cells LIM Domain Proteins Mice Molecular Sequence Data Myeloid Progenitor Cells Protein Binding Proto-Oncogene Proteins Regulatory Sequences Nucleic Acid Sequence Homology Nucleic Acid Silencer Elements Transcriptional T-Lymphocytes
Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell.
Anasuya Chattopadhyay, Cornelius J O'Connor, Fengzhi Zhang, Celine Galvagnion, Warren RJD Galloway, Yaw Sing Tan, Jamie E Stokes, Taufiq Rahman, Chandra Verma, David R Spring, Laura S Itzhaki
Mar 10, 2016
Antineoplastic Agents Aurora Kinase A Benzenesulfonates Calorimetry Cell Cycle Proteins Cell Line Tumor Cell Survival DNA Damage Escherichia coli Gene Expression Profiling Gene Expression Regulation Neoplastic Humans Magnetic Resonance Spectroscopy Mass Spectrometry Microtubule-Associated Proteins Neoplasms Nuclear Proteins Proteasome Endopeptidase Complex Proto-Oncogene Proteins Rad51 Recombinase Thermodynamics Triazoles Tumor Suppressor Protein p53
Dynamic expression of TET1, TET2, and TET3 dioxygenases in mouse and human placentas throughout gestation.
Joanna Rakoczy, Nisha Padmanabhan, Ada M Krzak, Jens Kieckbusch, Tereza Cindrova-Davies, Erica D Watson
Apr 18, 2018
INTRODUCTION: Throughout pregnancy, the placenta dynamically changes as trophoblast progenitors differentiate into mature trophoblast cell subtypes. This process is in part controlled by epigenetic regulation of DNA methylation...
Epigenetic modifiers DNMT3A and BCOR are recurrently mutated in CYLD cutaneous syndrome.
Helen R Davies, Kirsty Hodgson, Edward Schwalbe, Jonathan Coxhead, Naomi Sinclair, Xueqing Zou, Simon Cockell, Akhtar Husain, Serena Nik-Zainal, Neil Rajan
Nov 09, 2019
DNA (Cytosine-5-)-Methyltransferases DNA Methylation DNA Methyltransferase 3A DNA Mutational Analysis Deubiquitinating Enzyme CYLD Epigenesis Genetic Female Gene Expression Profiling Humans Male Mutation Neoplastic Syndromes Hereditary Pedigree Proto-Oncogene Proteins Repressor Proteins Retrospective Studies Skin Neoplasms Exome Sequencing
Myeloid-Epithelial-Reproductive Receptor Tyrosine Kinase and Milk Fat Globule Epidermal Growth Factor 8 Coordinately Improve Remodeling After Myocardial Infarction via Local Delivery of Vascular Endothelial Growth Factor.
Kiave-Yune Howangyin, Ivana Zlatanova, Cristina Pinto, Anta Ngkelo, Clément Cochain, Marie Rouanet, José Vilar, Mathilde Lemitre, Christian Stockmann, Bernd K Fleischmann, Ziad Mallat, Jean-Sébastien Silvestre
Jun 21, 2018
BACKGROUND: In infarcted heart, improper clearance of dying cells by activated neighboring phagocytes may precipitate the transition to heart failure. We analyzed the coordinated role of 2 major mediators of efferocytosis, the...
Inflammation MACROPHAGES Myocardial Infarction myocarditis Neovascularization Physiologic Animals Antigens surface MACROPHAGES Mice Mice Inbred C57BL Mice Knockout Mice Transgenic Milk Proteins Myocardial Infarction Phagocytosis Proto-Oncogene Proteins Receptor Protein-Tyrosine Kinases Vascular Endothelial Growth Factor A Ventricular Remodeling c-Mer Tyrosine Kinase
Creating cellular diversity through transcription factor competition.
Berthold Göttgens
Apr 22, 2015
Resolving early mesoderm diversification through single-cell expression profiling.
Antonio Scialdone, Yosuke Tanaka, Wajid Jawaid, Victoria Moignard, Nicola K Wilson, Iain C Macaulay, John C Marioni, Berthold Göttgens
Jul 07, 2016
The DDX6-4E-T interaction mediates translational repression and P-body assembly.
Anastasiia Kamenska, Clare Simpson, Caroline Vindry, Helen Broomhead, Marianne Bénard, Michèle Ernoult-Lange, Benjamin P Lee, Lorna W Harries, Dominique Weil, Nancy Standart
Jul 12, 2016
Amino Acid Sequence Binding Sites DEAD-box RNA Helicases DNA-Binding Proteins Eukaryotic Initiation Factor-4E Eukaryotic Initiation Factor-4G Gene Expression Regulation HEK293 Cells HeLa Cells Humans Nucleocytoplasmic Transport Proteins Protein Binding Protein Biosynthesis Protein Interaction Maps Proto-Oncogene Proteins RNA Small Interfering RNA-Binding Proteins Transcription Factors
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