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Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis.
Chun Gong, Joanna A Krupka, Jie Gao, Nicholas F Grigoropoulos, George Giotopoulos, Ryan Asby, Michael Screen, Zelvera Usheva, Francesco Cucco, Sharon Barrans, Daniel Painter, Nurmahirah Binte Mohammed Zaini, Björn Haupl, Susanne Bornelöv, Igor Ruiz De Los Mozos, Wei Meng, Peixun Zhou, Alex E Blain, Sorcha Forde, Jamie Matthews, Michelle Guet Khim Tan, GA Amos Burke, Siu Kwan Sze, Philip Beer, Cathy Burton, Peter Campbell, Vikki Rand, Suzanne D Turner, Jernej Ule, Eve Roman, Reuben Tooze, Thomas Oellerich, Brian J Huntly, Martin Turner, Ming-Qing Du, Shamith A Samarajiwa, Daniel J Hodson
Jul 30, 2021
DDX3X is a ubiquitously expressed RNA helicase involved in multiple stages of RNA biogenesis. DDX3X is frequently mutated in Burkitt lymphoma, but the functional basis for this is unknown. Here, we show that loss-of-function...
Burkitt lymphoma DDX3X Myc RNA helicase Germinal Center proteotoxic stress Translation Adolescent Adult Aged Aged 80 and over Animals B-Lymphocytes Cell Line Tumor Child Child Preschool DEAD-box RNA Helicases Endoplasmic reticulum stress Female Gene Expression Regulation Enzymologic Gene Expression Regulation Neoplastic Humans Loss of Function Mutation Lymphoma B-Cell Male Mice Transgenic Middle Aged Minor Histocompatibility Antigens Neoplasm Proteins Protein Biosynthesis Proteome Proteostasis Proto-Oncogene Proteins c-myc Young Adult
Heterogeneity of Myc expression in breast cancer exposes pharmacological vulnerabilities revealed through executable mechanistic modeling.
Peter Kreuzaler, Matthew A Clarke, Elizabeth J Brown, Catherine H Wilson, Roderik M Kortlever, Nir Piterman, Trevor Littlewood, Gerard I Evan, Jasmin Fisher
Oct 14, 2019
Cells with higher levels of Myc proliferate more rapidly and supercompetitively eliminate neighboring cells. Nonetheless, tumor cells in aggressive breast cancers typically exhibit significant and stable heterogeneity in their...
Distinct genetic changes reveal evolutionary history and heterogeneous molecular grade of DLBCL with MYC/BCL2 double-hit.
Francesco Cucco, Sharon Barrans, Chulin Sha, Alexandra Clipson, Simon Crouch, Rachel Dobson, Zi Chen, Joe Sneath Thompson, Matthew A Care, Thomas Cummin, Josh Caddy, Hongxiang Liu, Anne Robinson, Anna Schuh, Jude Fitzgibbon, Daniel Painter, Alexandra Smith, Eve Roman, Reuben Tooze, Catherine Burton, Andrew J Davies, David R Westhead, Peter WM Johnson, Ming-Qing Du
Nov 22, 2019
Using a Burkitt lymphoma-like gene expression signature, we recently defined a high-risk molecular high-grade (MHG) group mainly within germinal centre B-cell like diffuse large B-cell lymphomas (GCB-DLBCL), which was enriched...
Biomarkers Tumor Clonal Evolution Female Gene Expression Profiling Gene Expression Regulation Leukemic Gene Rearrangement Humans Lymphoma Large B-Cell Diffuse Male Middle Aged Mutation Phenotype Prognosis Proto-Oncogene Proteins c-bcl-2 Proto-Oncogene Proteins c-myc Survival Rate Translocation Genetic
Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide
Transcription factor co-localization patterns affect human cell type-specific gene expression.
MYC sensitises cells to apoptosis by driving energetic demand.
Joy Edwards-Hicks, Huizhong Su, Maurizio Mangolini, Kubra K Yoneten, Jimi Wills, Giovanny Rodriguez-Blanco, Christine Young, Kevin Cho, Heather Barker, Morwenna Muir, Ania Naila Guerrieri, Xue-Feng Li, Rachel White, Piotr Manasterski, Elena Mandrou, Karen Wills, Jingyu Chen, Emily Abraham, Kianoosh Sateri, Bin-Zhi Qian, Peter Bankhead, Mark Arends, Noor Gammoh, Alex Von Kriegsheim, Gary J Patti, Andrew H Sims, Juan Carlos Acosta, Valerie Brunton, Kamil R Kranc, Maria Christophorou, Erika L Pearce, Ingo Ringshausen, Andrew J Finch
Sep 09, 2022
Association between genetic polymorphisms and endometrial cancer risk
Cemsel Bafligil, Deborah J Thompson, Artitaya Lophatananon, Miriam J Smith, Neil AJ Ryan, Anie Naqvi, D Gareth Evans, Emma J Crosbie
Feb 10, 2020
endometrial cancer Genetic epidemiology Risk prediction single nucleotide polymorphism (SNP) Systematic review Aromatase Endometrial Neoplasms Female Genetic Predisposition to Disease Genome-Wide Association Study Hepatocyte Nuclear Factor 1-beta Humans Kruppel-Like Transcription Factors Polymorphism Single Nucleotide Prospective Studies Proto-Oncogene Proteins c-mdm2 Proto-Oncogene Proteins c-myc Risk Factors SOXC Transcription Factors eIF-2 Kinase
OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors.
LA Jung, A Gebhardt, W Koelmel, CP Ade, S Walz, J Kuper, B von Eyss, S Letschert, C Redel, L d'Artista, A Biankin, L Zender, M Sauer, E Wolf, G Evan, C Kisker, M Eilers
Aug 05, 2019
MYC genes have both essential roles during normal development and exert oncogenic functions during tumorigenesis. Expression of a dominant-negative allele of MYC, termed OmoMYC, can induce rapid tumor regression in mouse models...
Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon.
Induced pluripotent stem cells (iPSCs) have been generated from somatic cells by transgenic expression of Oct4 (Pou5f1), Sox2, Klf4 and Myc. A major difficulty in the application of this technology for regenerative medicine...
Alkaline phosphatase Animals Cell Dedifferentiation Cell Differentiation Chimera Chromosomal Proteins Non-Histone DNA Transposable Elements Embryo Mammalian FIBROBLASTS Gene Expression Genetic Vectors Homeodomain Proteins Humans Kruppel-Like Factor 4 Kruppel-Like Transcription Factors Mice Moths Nanog Homeobox Protein Octamer Transcription Factor-3 Pluripotent Stem Cells Proto-Oncogene Proteins c-myc RNA-Binding Proteins Repressor Proteins SOXB1 Transcription Factors Teratoma Transfection Transgenes Transposases Valproic acid
The Protein Arginine Methyltransferases 1 and 5 affect Myc properties in glioblastoma stem cells.
Annarita Favia, Luisa Salvatori, Simona Nanni, Lisa K Iwamoto-Stohl, Sergio Valente, Antonello Mai, Fiorella Scagnoli, Rosaria Anna Fontanella, Pierangela Totta, Sergio Nasi, Barbara Illi
Nov 03, 2020
Protein Arginine (R) methylation is the most common post-translational methylation in mammalian cells. Protein Arginine Methyltransferases (PRMT) 1 and 5 dimethylate their substrates on R residues, asymmetrically and...
Antibodies Cell Cycle Checkpoints Cell Differentiation Cell Line Tumor Glioblastoma HEK293 Cells Humans Methylation Neoplastic Stem Cells Promoter Regions Genetic Protein Binding Protein Stability Protein-Arginine N-Methyltransferases Proto-Oncogene Proteins c-myc RNA Interference RNA Small Interfering Repressor Proteins SOXB1 Transcription Factors
Epstein-Barr virus subverts mevalonate and fatty acid pathways to promote infected B-cell proliferation and survival.
Liang Wei Wang, Zhonghao Wang, Ina Ersing, Luis Nobre, Rui Guo, Sizun Jiang, Stephen Trudeau, Bo Zhao, Michael P Weekes, Benjamin E Gewurz
Aug 19, 2019
Epstein-Barr virus (EBV) causes infectious mononucleosis and is associated with multiple human malignancies. EBV drives B-cell proliferation, which contributes to the pathogenesis of multiple lymphomas. Yet, knowledge of how EBV...
Alkyl and Aryl Transferases B-Lymphocytes Cell Proliferation Cell Survival Cholesterol Epstein-Barr Virus Infections Epstein-Barr Virus Nuclear Antigens Fatty Acids Herpesvirus 4 Human Host Microbial Interactions Humans Metabolic Networks and Pathways Mevalonic Acid Proto-Oncogene Proteins c-myc Sterol Regulatory Element Binding Protein 2 Viral Proteins rab GTP-Binding Proteins
The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers.
Leila Jahangiri, Perla Pucci, Tala Ishola, Ricky M Trigg, John A Williams, Joao Pereira, Megan L Cavanagh, Suzanne D Turner, Georgios V Gkoutos, Loukia Tsaprouni
Aug 06, 2021
MYC is a target of the Wnt signalling pathway and governs numerous cellular and developmental programmes hijacked in cancers. The amplification of MYC is a frequently occurring genetic alteration in cancer genomes, and this...
Myc Cooperates with Ras by Programming Inflammation and Immune Suppression.
Roderik M Kortlever, Nicole M Sodir, Catherine H Wilson, Deborah L Burkhart, Luca Pellegrinet, Lamorna Brown Swigart, Trevor D Littlewood, Gerard I Evan
Jan 31, 2018
The two oncogenes KRas and Myc cooperate to drive tumorigenesis, but the mechanism underlying this remains unclear. In a mouse lung model of KRasG12D-driven adenomas, we find that co-activation of Myc drives the immediate...
CCL9 IL-23 Myc NK cells Ras immune suppression Inflammation Lung cancer oncogene cooperation Tumor Microenvironment Adenocarcinoma Adenoma Animals Carcinogenesis Chemokines CC Disease Models Animal Female Inflammation Interleukin-23 Lung Neoplasms Macrophage Inflammatory Proteins MACROPHAGES Male Mice Proto-Oncogene Proteins c-myc Proto-Oncogene Proteins p21(ras) Tumor Microenvironment
MYC functions are specific in biological subtypes of breast cancer and confers resistance to endocrine therapy in luminal tumours.
Andrew R Green, Mohammed A Aleskandarany, Devika Agarwal, Somaia Elsheikh, Christopher C Nolan, Maria Diez-Rodriguez, R Douglas Macmillan, Graham R Ball, Carlos Caldas, Srinivasan Madhusudan, Ian O Ellis, Emad A Rakha
Jan 11, 2018
BACKGROUND: MYC is amplified in approximately 15% of breast cancers (BCs) and is associated with poor outcome. c-MYC protein is multi-faceted and participates in many aspects of cellular function and is linked with therapeutic...
Aged Ataxia Telangiectasia Mutated Proteins Biomarkers Tumor Breast Neoplasms Class I Phosphatidylinositol 3-Kinases Cyclin B1 Cyclin E Disease-Free Survival Drug Resistance Neoplasm Endocrine Cells Female Gene Expression Profiling Gene Expression Regulation Neoplastic Humans Phosphatidylinositol 3-Kinases Prognosis Proto-Oncogene Proteins c-myc RNA Messenger Receptor ErbB-2
Quantitative Expression and Co-Localization of Wnt Signalling Related Proteins in Feline Squamous Cell Carcinoma.
Antonio Giuliano, Rebecca Swift, Callum Arthurs, Georgina Marote, Francesca Abramo, Jenny McKay, Calum Thomson, Mariana Beltran, Michael Millar, Simon Priestnall, Jane Dobson, Fernando Costantino-Casas, Terry Petrou, Imelda M McGonnell, Anthony J Davies, Malcolm Weetman, Oliver A Garden, John R Masters, Christopher Thrasivoulou, Aamir Ahmed
Sep 22, 2016
Animals Carcinoma Squamous Cell Cat Diseases Cats Cyclin D1 Gene Expression Regulation Neoplastic Hydrogen-Ion Concentration Matrix Metalloproteinase 7 Microtubule-Associated Proteins Mouth Neoplasms Neoplasm Proteins Proto-Oncogene Proteins c-myc ROC Curve Transcription Factors Wnt Proteins Wnt Signaling Pathway beta Catenin
The renal lineage factor PAX8 controls oncogenic signalling in kidney cancer.
Saroor A Patel, Shoko Hirosue, Paulo Rodrigues, Erika Vojtasova, Emma K Richardson, Jianfeng Ge, Saiful E Syafruddin, Alyson Speed, Evangelia K Papachristou, David Baker, David Clarke, Stephenie Purvis, Ludovic Wesolowski, Anna Dyas, Leticia Castillon, Veronica Caraffini, Dóra Bihary, Cissy Yong, David J Harrison, Grant D Stewart, Mitchell J Machiela, Mark P Purdue, Stephen J Chanock, Anne Y Warren, Shamith A Samarajiwa, Jason S Carroll, Sakari Vanharanta
Jul 09, 2022
Reversible Myc hypomorphism identifies a key Myc-dependency in early cancer evolution
Nicole Sodir, Luca Pellegrinet, Roderik Kortlever, Tania Campos, Yong-won Kwon, Shinseog Kim, Daniel Garcia, Alessandra Perfetto, Panayiotis Anastasiou, Lamorna Brown Swigart, Mark Arends, Trevor Littlewood, Gerard Evan
Dec 10, 2022
Germ-line hypomorphism of the pleiotropic transcription factor Myc in mice, either through Myc gene haploinsufficiency or deletion of Myc enhancers, delays onset of various cancers while mice remain viable and exhibit only...
MicroRNA-155 controls affinity-based selection by protecting c-MYC+ B cells from apoptosis.
Rinako Nakagawa, Rebecca Leyland, Michael Meyer-Hermann, Dong Lu, Martin Turner, Giuseppina Arbore, Tri Giang Phan, Robert Brink, Elena Vigorito
May 24, 2019
Oncogenic KRAS triggers MAPK-dependent errors in mitosis and MYC-dependent sensitivity to anti-mitotic agents.
Active Transport Cell Nucleus Antineoplastic Agents Cell Line Tumor Cell Nucleus Chromosome Segregation HCT116 Cells HeLa Cells Humans Microscopy Confocal Mitogen-Activated Protein Kinases Mitosis Mutation Proto-Oncogene Proteins c-myc Proto-Oncogene Proteins p21(ras) RNA Interference Time-Lapse Imaging
Convergence of cMyc and β-catenin on Tcf7l1 enables endoderm specification.
FoxA2 Myc Tcf7l1 Embryonic Stem Cells Endoderm Activins Animals Cell Differentiation Cells Cultured Embryonic Stem Cells Endoderm Gene Expression Regulation Glycogen Synthase Kinase 3 Hepatocyte Nuclear Factor 3-beta Mice Proto-Oncogene Proteins c-myc Signal Transduction Transcription Factor 7-Like 1 Protein beta Catenin
Ascl1 phospho-status regulates neuronal differentiation in a Xenopus developmental model of neuroblastoma.
Ascl1 Cell Cycle development DIFFERENTIATION Neuroblastoma Xenopus Adrenergic Neurons Animals Basic Helix-Loop-Helix Transcription Factors Biomarkers Cell Differentiation Cell Movement Cyclin-Dependent Kinase Inhibitor p27 Cyclin-Dependent Kinases Disease Models Animal Embryo Nonmammalian Gene Knockdown Techniques Morpholinos Nerve Tissue Proteins Neural Crest Neuroblastoma Neurogenesis Neurons Phosphorylation Proto-Oncogene Proteins c-myc Xenopus Proteins Xenopus laevis
Metabolic Imaging Detects Low Levels of Glycolytic Activity That Vary with Levels of c-Myc Expression in Patient-Derived Xenograft Models of Glioblastoma.
Richard Mair, Alan J Wright, Susana Ros, De-En Hu, Tom Booth, Felix Kreis, Jyotsna Rao, Colin Watts, Kevin M Brindle
Oct 03, 2018
Deciphering c-MYC-regulated genes in two distinct tissues.
Samuel C Robson, Lesley Ward, Helen Brown, Heather Turner, Ewan Hunter, Stella Pelengaris, Michael Khan
Feb 23, 2012
The opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis.
Elisabete M Nascimento, Claire L Cox, Stewart MacArthur, Shobbir Hussain, Matthew Trotter, Sandra Blanco, Menon Suraj, Jennifer Nichols, Bernd Kübler, Salvador Aznar Benitah, Brian Hendrich, Duncan T Odom, Michaela Frye
Jan 31, 2020
How the proto-oncogene c-Myc balances the processes of stem-cell self-renewal, proliferation and differentiation in adult tissues is largely unknown. We explored c-Myc's transcriptional roles at the epidermal differentiation...
Animals Epidermal Cells epidermis Feedback Physiological Female Homeostasis Keratinocytes Kruppel-Like Factor 4 Male Mice Mice Inbred C57BL Mice Inbred CBA Mice Transgenic Primary Cell Culture Proto-Oncogene Proteins c-myc Repressor Proteins Sin3 Histone Deacetylase and Corepressor Complex Transcription Genetic
Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation.
Liang Wei Wang, Hongying Shen, Luis Nobre, Ina Ersing, Joao A Paulo, Stephen Trudeau, Zhonghao Wang, Nicholas A Smith, Yijie Ma, Bryn Reinstadler, Jason Nomburg, Thomas Sommermann, Ellen Cahir-McFarland, Steven P Gygi, Vamsi K Mootha, Michael P Weekes, Benjamin E Gewurz
Jun 05, 2019
Epstein-Barr virus (EBV) causes Burkitt, Hodgkin, and post-transplant B cell lymphomas. How EBV remodels metabolic pathways to support rapid B cell outgrowth remains largely unknown. To gain insights, primary human B cells were...
B-cell activation de novo serine synthesis folate isotope tracing metabolic remodeling mitochondrial one-carbon metabolism quantitative proteomics tandem mass tag tumor virus virus oncoprotein Aminohydrolases B-Lymphocytes Cell Transformation Viral Epstein-Barr Virus Infections Epstein-Barr Virus Nuclear Antigens Female Folic Acid Glycolysis HEK293 Cells Herpesvirus 4 Human Humans Lymphocyte Activation Methylenetetrahydrofolate Dehydrogenase (NADP) Mitochondria Multifunctional Enzymes NADP Oxidation-Reduction Proteome Proto-Oncogene Proteins c-myc Serine
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