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Relaxin/insulin-like family peptide receptor 4 (Rxfp4) expressing hypothalamic neurons modulate food intake and preference in mice.
Jo E Lewis, Orla RM Woodward, Danaé Nuzzaci, Christopher A Smith, Alice E Adriaenssens, Lawrence Billing, Cheryl Brighton, Benjamin U Phillips, John A Tadross, Sarah J Kinston, Ernesto Ciabatti, Berthold Göttgens, Marco Tripodi, David Hornigold, David Baker, Fiona M Gribble, Frank Reimann
Oct 21, 2022
OBJECTIVE: Insulin-like peptide 5 (INSL5) signalling, through its cognate receptor relaxin/insulin-like family peptide receptor 4 (RXFP4), has been reported to be orexigenic, and the high fat diet (HFD) preference observed in...