Search

Animals Galactose Galectin 3 Lipopolysaccharides MACROPHAGES Microglia Neuraminidase Neurons Opsonin Proteins Oseltamivir PC12 Cells Phagocytosis Proto-Oncogene Proteins Pyrazoles Pyrimidines Rats Receptor Protein-Tyrosine Kinases c-Mer Tyrosine Kinase

Anaplastic Lymphoma Kinase (ALK) is a receptor tyrosine kinase aberrantly expressed in a variety of tumor types, most notably in Anaplastic Large Cell Lymphoma (ALCL) where a chromosomal translocation generates the oncogenic...

Anaplastic Lymphoma Kinase Animals Cell Adhesion Cell Cycle Cell Proliferation Cell Transformation Neoplastic Cells Cultured Cellular Senescence Cyclin-Dependent Kinase Inhibitor p16 Embryo Mammalian FIBROBLASTS Humans Mice Models Biological Mutation Protein Processing Post-Translational Protein Stability Protein-Tyrosine Kinases Receptor Protein-Tyrosine Kinases Retinoblastoma Protein Transcription Genetic Tumor Suppressor Protein p53

BACKGROUND: The fibroblast growth factor (FGF) axis is an important mitogenic stimulus in prostate carcinogenesis. We have previously reported that transcript level of human similar expression to FGF (hSef), a key regulator of...

Animals Cell Growth Processes Cell Line Tumor Down-Regulation Fibroblast Growth Factors Gene Expression Regulation Neoplastic Humans Male Mice Mice Nude Prostatic Neoplasms Receptor Protein-Tyrosine Kinases Receptors Interleukin Signal Transduction Transfection

Drug resistance invariably limits the clinical efficacy of targeted therapy with kinase inhibitors against cancer. Here we show that targeted therapy with BRAF, ALK or EGFR kinase inhibitors induces a complex network of secreted...

Adenocarcinoma Anaplastic Lymphoma Kinase Animals Cell Line Tumor Cell Movement Cell Proliferation Cell Survival Clone Cells Disease Progression Down-Regulation Drug Resistance Neoplasm Enzyme Activation ErbB Receptors Female Humans Lung Neoplasms Melanoma Metabolome Mice Neoplasm Metastasis Protein Kinase Inhibitors Proto-Oncogene Proteins B-raf Proto-Oncogene Proteins c-akt Proto-Oncogene Proteins c-fos Receptor Protein-Tyrosine Kinases Signal Transduction Tumor Microenvironment

COPII GTPase endoplasmic reticulum (ER) membrane bilayer membrane transport Amino Acid Substitution Animals COP-Coated Vesicles Caenorhabditis elegans Caenorhabditis elegans Proteins Endoplasmic Reticulum Enzyme Inhibitors GTP Phosphohydrolases GTPase-Activating Proteins Guanosine Triphosphate Guanylyl Imidodiphosphate Humans Lipid Bilayers Membrane Microdomains Microscopy Atomic Force Models Biological Monomeric GTP-Binding Proteins Mutation Organelle Shape RNA Interference Receptor Protein-Tyrosine Kinases Recombinant Proteins Vesicular Transport Proteins ras GTPase-Activating Proteins

Myasthenia gravis (MG) is a prototypical autoantibody mediated disease. The autoantibodies in MG target structures within the neuromuscular junction (NMJ), thus affecting neuromuscular transmission. The major disease subtypes of...

MuSK AChR B cells B lymphocytes Autoantibodies Autoimmunity immunopathology myasthenia gravis Animals Antibodies Bispecific Autoantibodies B-Lymphocytes Humans Immunoglobulin G LDL-Receptor Related Proteins Mice Myasthenia Gravis Pemphigus Polyradiculoneuropathy Chronic Inflammatory Demyelinating Receptor Protein-Tyrosine Kinases Receptors Cholinergic Receptors Nicotinic

BACKGROUND: In infarcted heart, improper clearance of dying cells by activated neighboring phagocytes may precipitate the transition to heart failure. We analyzed the coordinated role of 2 major mediators of efferocytosis, the...

Inflammation MACROPHAGES Myocardial Infarction myocarditis Neovascularization Physiologic Animals Antigens surface MACROPHAGES Mice Mice Inbred C57BL Mice Knockout Mice Transgenic Milk Proteins Myocardial Infarction Phagocytosis Proto-Oncogene Proteins Receptor Protein-Tyrosine Kinases Vascular Endothelial Growth Factor A Ventricular Remodeling c-Mer Tyrosine Kinase

Pulmonary arterial hypertension (PAH), is a fatal disease characterized by a pseudo-malignant phenotype. We investigated the expression and the role of the receptor tyrosine kinase Axl in experimental (i.e., monocrotaline and...

Angiogenesis Inhibitors Animals Bone Morphogenetic Protein Receptors Type II Gene Expression Regulation Indoles Male Monocrotaline pulmonary arterial hypertension Pyrroles Rats Inbred WKY Rats Sprague-Dawley Receptor Protein-Tyrosine Kinases

Cell Line Tumor Humans Lymphoma Large-Cell Anaplastic Mutation Neoplasm Recurrence Local Protein-Tyrosine Kinases Receptor Protein-Tyrosine Kinases Receptor Notch1 Exome Sequencing

Adenocarcinoma Aged Antineoplastic Agents CD8 Antigens Cell Line Tumor Cohort Studies DNA Damage DNA Neoplasm Esophageal Neoplasms Female Genetic Heterogeneity Genome Human Humans Male Mutation Poly(ADP-ribose) Polymerase Inhibitors Receptor Protein-Tyrosine Kinases Sequence Analysis DNA

OsARK2 SPARK receptor-like kinases Arbuscular mycorrhiza Amino Acid Sequence Mycorrhizae Oryza Phylogeny Protein Domains Receptor Protein-Tyrosine Kinases

Insertion of reporter cassettes into the Lgr5 locus has enabled the characterization of mouse intestinal stem cells (ISCs). However, low cell surface abundance of LGR5 protein and lack of high-affinity anti-LGR5 antibodies...

Cell Adhesion Molecules Cell Proliferation Cell Separation Cells Cultured Colon Humans Mass Spectrometry Organ Culture Techniques Receptor Protein-Tyrosine Kinases Stem Cells

ALCL ALK kinase IL-10 IL-21 IL-22 Cytokines miR-155 Anaplastic Lymphoma Kinase Animals Argonaute Proteins CCAAT-Enhancer-Binding Protein-beta Case-Control Studies Caspase 3 Cell Line Tumor Chromosomes Human Pair 2 Chromosomes Human Pair 5 DNA Methylation Gene Expression Regulation Neoplastic Genetic Therapy Humans Lymphoma Large-Cell Anaplastic Mice Inbred NOD Mice SCID MicroRNAs Promoter Regions Genetic Receptor Protein-Tyrosine Kinases STAT3 Transcription Factor Signal Transduction Suppressor of Cytokine Signaling 1 Protein Suppressor of Cytokine Signaling Proteins Transfection Translocation Genetic Xenograft Model Antitumor Assays

ALK inhibitors T cell lymphoma anaplastic large cell lymphoma Anaplastic Lymphoma Kinase Adolescent Adult Anaplastic Lymphoma Kinase Antineoplastic Agents Child Child Preschool Humans Lymphoma Large-Cell Anaplastic Middle Aged Molecular Targeted Therapy Receptor Protein-Tyrosine Kinases Young Adult

Anaplastic Lymphoma Kinase Animals Heterozygote Humans Lymphoma Mice Mice Knockout Nuclear Proteins Receptor Protein-Tyrosine Kinases

Despite current advancements in research and therapeutics, lung cancer remains the leading cause of cancer-related mortality worldwide. This is mainly due to the resistance that patients develop against chemotherapeutic agents...

AXL cancer biology epigenetics erlotinib-resistant human Lung cancer Acrylamides Aniline Compounds Antineoplastic Agents Carcinoma Non-Small-Cell Lung Cell Line Tumor Drug Resistance Neoplasm Epigenesis Genetic ErbB Receptors Erlotinib Hydrochloride Humans Intercellular Signaling Peptides and Proteins Lung Neoplasms MicroRNAs Mutation Protein Kinase Inhibitors Proto-Oncogene Proteins RNA Messenger Receptor Protein-Tyrosine Kinases