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Treatments to limit T cell activation are essential for managing autoimmune and inflammatory disorders. The B subunit of Escherichia coli heat-labile enterotoxin (EtxB) is known to ameliorate inflammatory disease in vivo but the...

EtxB Dendritic Cells immunomodulation Lung Regulatory T cells

Antigen Presentation Aorta Atherosclerosis indoleamine 2 3-dioxygenase plasmacytoid dendritic cells Regulatory T cells type I interferon

Flat-Coated Retriever dogs are predisposed to the development of histiocytic sarcoma (HS), a poorly differentiated, highly malignant neoplasm. The authors have previously documented a significant lymphocytic infiltrate in such...

flat-coated retriever cancer immunology Hematologic Neoplasms histiocytic sarcoma Regulatory T cells Tumor Microenvironment tumor-infiltrating lymphocytes

aging Brain gene therapy interleukin 2 Regulatory T cells

The NF-κB transcription factor c-Rel is a critical regulator of Treg ontogeny, controlling multiple points of the stepwise developmental pathway. Here, we found that the thymic Treg defect in c-Rel-deficient (cRel-/- ) mice is...

Cell cycle progression Regulatory T cells Thymic development c-Rel Animals Cell Differentiation Lymphocyte Activation Mice Mice Inbred C57BL Mice Knockout Proto-Oncogene Proteins c-rel T-Lymphocytes Regulatory Thymus Gland

We provide in this paper a detailed characterization of the human peripheral CD4$^+$ CD127$^{low}$CD25$^+$ regulatory T cell (Treg) compartment, with a particular emphasis in defining the population expressing higher levels of...

human immunology IL-6 receptor Immunophenotyping Regulatory T cells

Regulatory T cells T cells Blood Lymphocytes Eosinophils blood counts blood plasma memory T cells

Autoimmunity Cytokine therapy Graft versus host disease IL-2 fusion proteins Regulatory T cells Animals Biomarkers CTLA-4 Antigen Dose-Response Relationship Drug Eosinophilia Female Forkhead Transcription Factors Humans Interleukin-2 Interleukin-2 Receptor alpha Subunit Lymphocyte Count Macaca fascicularis Male Mice Mice Knockout Phenotype Phosphorylation Protein Binding Recombinant Fusion Proteins Recombinant Proteins STAT5 Transcription Factor Signal Transduction T-Lymphocyte Subsets T-Lymphocytes Regulatory

INTRODUCTION: Inflammation and dysregulated immune responses play a crucial role in atherosclerosis, underlying ischaemic heart disease (IHD) and acute coronary syndromes (ACSs). Immune responses are also major determinants of...

Acute Coronary Syndrome aldesleukin interleukin 2 ischaemic heart disease Regulatory T cells Acute Coronary Syndrome C-Reactive Protein Clinical Trials Phase I as Topic Clinical Trials Phase II as Topic Double-Blind Method Humans Immunologic Factors Interleukin-2 Interleukin-6 Lymphocyte Count Myocardial Ischemia Natriuretic Peptide Brain Randomized Controlled Trials as Topic Recombinant Proteins T-Lymphocytes Regulatory Troponin

The inflammatory response to transformed cells forms the cornerstone of natural or therapeutically induced protective immunity to cancer. Regulatory T (Treg) cells are known for their critical role in suppressing inflammation...

Cancer chemokine/chemokine receptors cytokines/cytokine receptors Regulatory T cells tumour immunology Animals Humans Inflammation Mediators Lymphocytes Tumor-Infiltrating Neoplasms Phenotype Signal Transduction T-Lymphocytes Regulatory Tumor Escape Tumor Microenvironment

Gastric cancer (GC) patients display increased regulatory T cell (Tregs) numbers in peripheral blood and among tumor-infiltrating lymphocytes. Nevertheless, the role of Tregs in GC progression remains controversial. Here, we...

gastric cancer molecular regulation Regulatory T cells tumor-infiltrating CD4 T cells