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Results: 24
Single-cell RNA-seq reveals hidden transcriptional variation in malaria parasites.
Adam J Reid, Arthur M Talman, Hayley M Bennett, Ana R Gomes, Mandy J Sanders, Christopher JR Illingworth, Oliver Billker, Matthew Berriman, Mara Kn Lawniczak
Oct 10, 2018
Single-cell RNA-sequencing is revolutionising our understanding of seemingly homogeneous cell populations but has not yet been widely applied to single-celled organisms. Transcriptional variation in unicellular malaria parasites...
Comparative genomic mapping reveals mechanisms of chromosome diversification in Rhipidomys species (Rodentia, Thomasomyini) and syntenic relationship between species of Sigmodontinae.
Vergiana dos Santos Paixão, Pablo Suárez, Willam Oliveira da Silva, Lena Geise, Malcolm Andrew Ferguson-Smith, Patricia Caroline Mary O'Brien, Ana Cristina Mendes-Oliveira, Rogério Vieira Rossi, Julio Cesar Pieczarka, Cleusa Yoshiko Nagamachi
Nov 18, 2021
Rhipidomys (Sigmodontinae, Thomasomyini) has 25 recognized species, with a wide distribution ranging from eastern Panama to northern Argentina. Cytogenetic data has been described for 13 species with 12 of them having 2n = 44...
Phylogenetic analyses of complete mitochondrial genome sequences suggest a basal divergence of the enigmatic rodent Anomalurus.
David S Horner, Konstantinos Lefkimmiatis, Aurelio Reyes, Carmela Gissi, Cecilia Saccone, Graziano Pesole
Nov 23, 2017
BACKGROUND: Phylogenetic relationships between Lagomorpha, Rodentia and Primates and their allies (Euarchontoglires) have long been debated. While it is now generally agreed that Rodentia constitutes a monophyletic sister-group...
Comparing BMD-derived genotoxic potency estimations across variants of the transgenic rodent gene mutation assay.
There is growing interest in quantitative analysis of in vivo genetic toxicity dose-response data, and use of point-of-departure (PoD) metrics such as the benchmark dose (BMD) for human health risk assessment (HHRA). Currently...
benchmark dose dose response analysis genetic toxicology human health risk assessment transgenic rodent gene mutation assay Animals Animals Genetically Modified Benchmarking DNA Damage Dimethylnitrosamine Dose-Response Relationship Drug Ethyl Methanesulfonate Ethylnitrosourea Humans Mice Mutagenicity Tests Mutation Risk Assessment Rodentia Transgenes
Molecular mechanisms governing offspring metabolic programming in rodent models of in utero stress.
The results of different human epidemiological datasets provided the impetus to introduce the now commonly accepted theory coined as 'developmental programming', whereby the presence of a stressor during gestation predisposes...
Extracellular Matrix Biomimetic Hydrogels, Encapsulated with Stromal Cell-Derived Factor 1, Improve the Composition of Foetal Tissue Grafts in a Rodent Model of Parkinson's Disease.
Vanessa Penna, Niamh Moriarty, Yi Wang, Kevin CL Law, Carlos W Gantner, Richard J Williams, David R Nisbet, Clare L Parish
Apr 25, 2022
Clinical studies have provided evidence for dopamine (DA) cell replacement therapy in Parkinson's Disease. However, grafts derived from foetal tissue or pluripotent stem cells (PSCs) remain heterogeneous, with a high proportion...
Parkinson’s disease SDF1 biomaterials Dopamine Hydrogel Laminin self-assembling peptide Stem Cells stromal cell-derived factor 1 Transplantation Animals Biomimetics Cell Differentiation Chemokine CXCL12 Dopamine Dopaminergic Neurons Extracellular Matrix Fetus Hydrogels Laminin Parkinson Disease Rodentia
Hybridization between subterranean tuco-tucos (Rodentia, Ctenomyidae) with contrasting phylogenetic positions.
Bruno Busnello Kubiak, Rafael Kretschmer, Leonardo Trindade Leipnitz, Renan Maestri, Thamara Santos de Almeida, Leandro Rodrigues Borges, Daniel Galiano, Jorge C Pereira, Edivaldo Herculano Corrêa de Oliveira, Malcolm A Ferguson-Smith, Thales Renato Ochotorena de Freitas
Mar 02, 2020
Reproductive compatibility usually decreases according to increasing genetic difference and the time of divergence between species. However, the amount of modification required to influence hybridization may vary in different...
The gut microbial metabolic capacity of microbiome-humanized vs. wild type rodents reveals a likely dual role of intestinal bacteria in hepato-intestinal schistosomiasis.
Alba Cortés, John Martin, Bruce A Rosa, Klara A Stark, Simon Clare, Catherine McCarthy, Katherine Harcourt, Cordelia Brandt, Charlotte Tolley, Trevor D Lawley, Makedonka Mitreva, Matthew Berriman, Gabriel Rinaldi, Cinzia Cantacessi
Nov 23, 2022
Sample descriptors linked to metagenomic sequencing data from human and animal enteric samples from Vietnam.
Mark Woolhouse, Jordan Ashworth, Carlijn Bogaardt, Ngo Tri Tue, Steve Baker, Guy Thwaites, Tran My Phuc
May 17, 2021
There is still limited information on the diversity of viruses co-circulating in humans and animals. Here, we report data obtained from a large field collection of enteric samples taken from humans, pigs, rodents and other...
MRSA carrying mecC in captive mara.
WGS methicillin resistance wildlife zoo Animals Animals Zoo Anti-Bacterial Agents DNA Bacterial Denmark Genes Bacterial Genome Bacterial Methicillin-Resistant Staphylococcus aureus Microbial Sensitivity Tests Polymerase Chain Reaction Rodentia Sequence Analysis DNA Staphylococcal Infections Virulence Factors
Models of endometriosis and their utility in studying progression to ovarian clear cell carcinoma.
Claire M King, Cynthia Barbara, Andrew Prentice, James D Brenton, D Stephen Charnock-Jones
Oct 07, 2015
animal model clear cell ovarian cancer endometrioid ovarian cancer endometriosis menstruation Adenocarcinoma Clear Cell Animals Carcinoma Ovarian Epithelial Cell Transformation Neoplastic Disease Models Animal Disease Progression Endometrial Neoplasms Endometriosis Female Humans Menstruation Neoplasms Glandular and Epithelial Ovarian Neoplasms Primates Rabbits Rodentia Transplantation Heterologous
Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity
AE Hendricks, EG Bochukova, G Marenne, JM Keogh, N Atanassova, R Bounds, E Wheeler, V Mistry, E Henning, A Körner, D Muddyman, S McCarthy, A Hinney, J Hebebrand, RA Scott, C Langenberg, NJ Wareham, P Surendran, JM Howson, AS Butterworth, J Danesh, BG Nordestgaard, SF Nielsen, S Afzal, S Papadia, S Ashford, S Garg, GL Millhauser, RI Palomino, A Kwasniewska, I Tachmazidou, S O'Rahilly, E Zeggini, I Barroso, IS Farooqi, Understanding Society Scientific Group, EPIC-CVD Consortium, UK10K consortium
Aug 22, 2017
A Unified Framework for the Infection Dynamics of Zoonotic Spillover and Spread.
Giovanni Lo Iacono, Andrew A Cunningham, Elisabeth Fichet-Calvet, Robert F Garry, Donald S Grant, Melissa Leach, Lina M Moses, Gordon Nichols, John S Schieffelin, Jeffrey G Shaffer, Colleen T Webb, James LN Wood
Sep 28, 2016
The emergence of a new sex-system (XX/XY1Y2) suggests a species complex in the "monotypic" rodent Oecomys auyantepui (Rodentia, Sigmodontinae).
Willam Oliveira da Silva, Celina Coelho Rosa, Malcolm Andrew Ferguson-Smith, Patricia Caroline Mary O'Brien, Juliane Saldanha, Rogério Vieira Rossi, Julio Cesar Pieczarka, Cleusa Yoshiko Nagamachi
Jun 29, 2022
X-autosome translocation (XY1Y2) has been reported in distinct groups of vertebrates suggesting that the rise of a multiple sex system within a species may act as a reproductive barrier and lead to speciation. The viability of...
Chromosomal Signatures Corroborate the Phylogenetic Relationships within Akodontini (Rodentia, Sigmodontinae).
Willam Oliveira da Silva, Stella Miranda Malcher, Adenilson Leão Pereira, Julio Cesar Pieczarka, Malcolm Andrew Ferguson-Smith, Patricia Caroline Mary O'Brien, Ana Cristina Mendes-Oliveira, Lena Geise, Cleusa Yoshiko Nagamachi
Jun 22, 2020
Comparative chromosome-painting analysis among highly rearranged karyotypes of Sigmodontinae rodents (Rodentia, Cricetidae) detects conserved syntenic blocks, which are proposed as chromosomal signatures and can be used as...
The Mammary Microenvironment in Mastitis in Humans, Dairy Ruminants, Rabbits and Rodents
The One Health concept promotes integrated evaluation of human, animal, and environmental health questions to expedite advances benefiting all species. A recognition of the multi-species impact of mastitis as a painful condition...
Neurobehavioural sequelae of social deprivation in rodents revisited
TW Robbins
Apr 11, 2018
The significance of investigating effects of deprivation of social experience in rodents is reviewed in the context of the review by Robbins et al. (1996) in the Journal of Psychopharmacology (10: 39-47). The early development...
ADHD Social Isolation animal model Cognition Dopamine Hippocampus hyperactivity Prefrontal Cortex prepulse inhibition Schizophrenia Serotonin Striatum Animals Attention Deficit Disorder with Hyperactivity Behavior Animal Cognition Dopamine Hippocampus Humans Mental Disorders motivation Rodentia Schizophrenia Serotonin Social Isolation
Comment on " In Vivo [18F]GE-179 Brain Signal Does Not Show NMDA-Specific Modulation with Drug Challenges in Rodents and Nonhuman Primates".
Colm J McGinnity, Erik Årstad, Katherine Beck, David J Brooks, Jonathan P Coles, John S Duncan, Marian Galovic, Rainer Hinz, Ella Hirani, Oliver D Howes, Paul A Jones, Matthias J Koepp, Feng Luo, Daniela A Riaño Barros, Nisha Singh, William Trigg, Alexander Hammers
Oct 03, 2018
Schoenberger and colleagues ( Schoenberger et al. ( 2018 ) ACS Chem. Neurosci. 9 , 298 - 305 ) recently reported attempts to demonstrate specific binding of the positron emission tomography (PET) radiotracer, [18F]GE-179, to...
Detection and Characterization of Homologues of Human Hepatitis Viruses and Pegiviruses in Rodents and Bats in Vietnam.
Dung Van Nguyen, Cuong Van Nguyen, David Bonsall, Tue Tri Ngo, Juan Carrique-Mas, Anh Hong Pham, Juliet E Bryant, Guy Thwaites, Stephen Baker, Mark Woolhouse, Peter Simmonds
Apr 10, 2019
Rodents and bats are now widely recognised as important sources of zoonotic virus infections in other mammals, including humans. Numerous surveys have expanded our knowledge of diverse viruses in a range of rodent and bat...
Mammalian deltavirus without hepadnavirus coinfection in the neotropical rodent Proechimys semispinosus.
Sofia Paraskevopoulou, Fabian Pirzer, Nora Goldmann, Julian Schmid, Victor Max Corman, Lina Theresa Gottula, Simon Schroeder, Andrea Rasche, Doreen Muth, Jan Felix Drexler, Alexander Christoph Heni, Georg Joachim Eibner, Rachel A Page, Terry C Jones, Marcel A Müller, Simone Sommer, Dieter Glebe, Christian Drosten
Jul 14, 2020
Hepatitis delta virus (HDV) is a human hepatitis-causing RNA virus, unrelated to any other taxonomic group of RNA viruses. Its occurrence as a satellite virus of hepatitis B virus (HBV) is a singular case in animal virology for...