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Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids.
Kwang Bo Jung, Hana Lee, Ye Seul Son, Mi-Ok Lee, Young-Dae Kim, Soo Jin Oh, Ohman Kwon, Sunwha Cho, Hyun-Soo Cho, Dae-Soo Kim, Jung-Hwa Oh, Matthias Zilbauer, Jeong-Ki Min, Cho-Rok Jung, Janghwan Kim, Mi-Young Son
Nov 21, 2018
Human pluripotent stem cell (hPSC)-derived intestinal organoids (hIOs) form 3D structures organized into crypt and villus domains, making them an excellent in vitro model system for studying human intestinal development and...
Liver-heart crosstalk controls IL-22 activity in cardiac protection after myocardial infarction.
Ting-Ting Tang, Yuan-Yuan Li, Jing-Jing Li, Ke Wang, Yue Han, Wen-Yong Dong, Zheng-Feng Zhu, Ni Xia, Shao-Fang Nie, Min Zhang, Zhi-Peng Zeng, Bing-Jie Lv, Jiao Jiao, Heng Liu, Zong-Shu Xian, Xiang-Ping Yang, Yu Hu, Yu-Hua Liao, Qing Wang, Xin Tu, Ziad Mallat, Yu Huang, Guo-Ping Shi, Xiang Cheng
Nov 22, 2018
Interleukin (IL)-22 regulates tissue inflammation and repair. Here we report participation of the liver in IL-22-mediated cardiac repair after acute myocardial infarction (MI). Methods: We induced experimental MI in mice by...
Requirement for STAT3 and its target, TFCP2L1, in self-renewal of naïve pluripotent stem cells in vivo and in vitro.
Sophie Kraunsoe, Takuya Azami, Yihan Pei, Graziano Martello, Kenneth Jones, Thorsten Boroviak, Jennifer Nichols
Jan 17, 2023
OCT4 induces embryonic pluripotency via STAT3 signaling and metabolic mechanisms.
Giuliano G Stirparo, Agata Kurowski, Ayaka Yanagida, Lawrence E Bates, Stanley E Strawbridge, Siarhei Hladkou, Hannah T Stuart, Thorsten E Boroviak, Jose CR Silva, Jennifer Nichols
Jan 08, 2021
OCT4 STAT3 pathway developmental biology metabolism single-cell profiling Animals Blastocyst Inner Cell Mass Cell Lineage Embryo Mammalian Embryonic Development Gene Expression Regulation Developmental Glycolysis Mice Octamer Transcription Factor-3 Pluripotent Stem Cells STAT3 Transcription Factor Signal Transduction Single-Cell Analysis
The Multifaceted Role of STAT3 in Mammary Gland Involution and Breast Cancer.
Since seminal descriptions of signal transducer and activator of transcription 3 (STAT3) as a signal transducer and transcriptional regulator, which is most usually activated by phosphorylation of a specific tyrosine residue, a...
4T1 CLCA STAT3 Breast Cancer chitinase 3-like 1 cow involution lysosome mammary gland microenvironment Animals Biomarkers Breast Neoplasms Cell Transformation Neoplastic Cellular Microenvironment Female Gene Expression Regulation Humans Mammary Glands Human STAT3 Transcription Factor Signal Transduction
Lung epithelial tip progenitors integrate glucocorticoid- and STAT3-mediated signals to control progeny fate.
Usua Laresgoiti, Marko Z Nikolić, Chandrika Rao, Jane L Brady, Rachel V Richardson, Emma J Batchen, Karen E Chapman, Emma L Rawlins
Oct 05, 2016
Glucocorticoid human Lung development MOUSE STAT3 Adenoviridae Alveolar Epithelial Cells Animals Cell Differentiation Cells Cultured Epithelial Cells Glucocorticoids Humans Lung Mice Mifepristone Pulmonary Alveoli Reverse Transcriptase Polymerase Chain Reaction STAT3 Transcription Factor Signal Transduction Stem Cells
A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models
GE Tyzack, CE Hall, CR Sibley, T Cymes, S Forostyak, G Carlino, IF Meyer, G Schiavo, S Zhang, GM Gibbons, J Newcombe, R Patani, A Lakatos
Jan 29, 2018
Amyotrophic Lateral Sclerosis Animals Anti-Inflammatory Agents Astrocytes Axons Cells Cultured Disease Models Animal Humans Inflammation Interleukin-6 Male Mice Mice Inbred C57BL Motor Neurons Neurons Neuroprotection Receptor EphB1 STAT3 Transcription Factor Sciatic Nerve Signal Transduction Transcriptome
Anti-oncostatin M antibody inhibits the pro-malignant effects of oncostatin M receptor overexpression in squamous cell carcinoma.
Justyna A Kucia-Tran, Valtteri Tulkki, Cinzia G Scarpini, Stephen Smith, Maja Wallberg, Marta Paez-Ribes, Angela M Araujo, Jan Botthoff, Maria Feeney, Katherine Hughes, Maria M Caffarel, Nicholas Coleman
Feb 13, 2018
The oncostatin M (OSM) receptor (OSMR) shows frequent gene copy number gains and overexpression in cervical squamous cell carcinomas (SCCs), associated with adverse clinical outcomes. In SCC cells that overexpress OSMR, the...
STAT3 cervix head and neck metastasis neutralizing antibodies oncostatin M receptor squamous cell carcinoma Animals Antineoplastic Agents Immunological Autocrine Communication Cell Line Tumor Female Gene Expression Regulation Neoplastic Head and Neck Neoplasms Humans Janus Kinase 2 Lung Neoplasms Mice Inbred NOD Mice SCID Oncostatin M Oncostatin M Receptor beta Subunit Phosphorylation STAT3 Transcription Factor Signal Transduction Squamous Cell Carcinoma of Head and Neck Suppressor of Cytokine Signaling 3 Protein Up-Regulation Uterine Cervical Neoplasms Xenograft Model Antitumor Assays
Developmental Expression and Glucocorticoid Control of the Leptin Receptor in Fetal Ovine Lung.
Miles J De Blasio, Maria Boije, Owen R Vaughan, Brett S Bernstein, Katie L Davies, Alice Plein, Sarah L Kempster, Gordon CS Smith, D Stephen Charnock-Jones, Dominique Blache, FB Peter Wooding, Dino A Giussani, Abigail L Fowden, Alison J Forhead
Aug 11, 2015
Caspase-dependent proteolytic cleavage of STAT3alpha in ES cells, in mammary glands undergoing forced involution and in breast cancer cell lines.
James R Matthews, Susan MR Watson, Maxine CL Tevendale, Christine J Watson, Alan R Clarke
Jun 16, 2011
Stat3 promotes mitochondrial transcription and oxidative respiration during maintenance and induction of naive pluripotency.
LIF STAT3 metabolism mitochondrial respiration Pluripotency Animals Cell Differentiation Cell Proliferation Cell Respiration Chromatin Immunoprecipitation Embryonic Stem Cells Gene Expression Regulation Leukemia Inhibitory Factor Mice Mitochondria Pluripotent Stem Cells STAT3 Transcription Factor Transcription Genetic
DDX3X loss is an adverse prognostic marker in diffuse large B-cell lymphoma and is associated with chemoresistance in aggressive non-Hodgkin lymphoma subtypes.
Atish Kizhakeyil, Nurmahirah Binte Mohammed Zaini, Zhi Sheng Poh, Brandon Han Siang Wong, Xinpeng Loh, Aik Seng Ng, Zun Siong Low, Praseetha Prasannan, Chun Gong, Michelle Guet Khim Tan, Chandramouli Nagarajan, Dachuan Huang, Pang Wan Lu, Jing Quan Lim, Sharon Barrans, Choon Kiat Ong, Soon Thye Lim, Wee Joo Chng, George Follows, Daniel J Hodson, Ming Qing Du, Yeow Tee Goh, Suat Hoon Tan, Nicholas Francis Grigoropoulos, Navin Kumar Verma
Oct 22, 2021
DDX3X mutation Drug Resistance Hematolymphoid malignancy Prognosis Tumour metastasis Antineoplastic Agents Biomarkers Tumor Cell Line Tumor Cyclin D1 DEAD-box RNA Helicases Disease Progression Drug Resistance Neoplasm Humans Lymphoma Large B-Cell Diffuse Lymphoma Non-Hodgkin Mitogen-Activated Protein Kinases Mutation Prognosis STAT3 Transcription Factor Exome Sequencing
Gene expression profiling of mammary gland development reveals putative roles for death receptors and immune mediators in post-lactational regression.
INTRODUCTION: In order to gain a better understanding of the molecular processes that underlie apoptosis and tissue regression in mammary gland, we undertook a large-scale analysis of transcriptional changes during the mouse...
Acute-Phase Reaction Animals Apoptosis Cytokines DNA-Binding Proteins Female Gene Expression Profiling Gene Expression Regulation Genes Immunity Innate Lactation Mammary Glands Animal Mice Mice Inbred C57BL Oligonucleotide Array Sequence Analysis Pregnancy Receptors Tumor Necrosis Factor STAT3 Transcription Factor Time Factors Trans-Activators Weaning
A 3-D in vitro co-culture model of mammary gland involution.
Jonathan J Campbell, Laur-Alexandru Botos, Timothy J Sargeant, Natalia Davidenko, Ruth E Cameron, Christine J Watson
Mar 10, 2015
Stat3 modulates chloride channel accessory protein expression in normal and neoplastic mammary tissue.
IL10RA modulates crizotinib sensitivity in NPM1-ALK+ anaplastic large cell lymphoma.
Nina Prokoph, Nicola A Probst, Liam C Lee, Jack M Monahan, Jamie D Matthews, Huan-Chang Liang, Klaas Bahnsen, Ivonne A Montes-Mojarro, Elif Karaca-Atabay, Geeta G Sharma, Vikas Malik, Hugo Larose, Sorcha D Forde, Stephen P Ducray, Cosimo Lobello, Qi Wang, Shi-Lu Luan, Šárka Pospíšilová, Carlo Gambacorti-Passerini, GA Amos Burke, Shahid Pervez, Andishe Attarbaschi, Andrea Janíková, Hélène Pacquement, Judith Landman-Parker, Anne Lambilliotte, Gudrun Schleiermacher, Wolfram Klapper, Ralf Jauch, Wilhelm Woessmann, Gilles Vassal, Lukas Kenner, Olaf Merkel, Luca Mologni, Roberto Chiarle, Laurence Brugières, Birgit Geoerger, Isaia Barbieri, Suzanne D Turner
May 26, 2020
Anaplastic large cell lymphoma (ALCL) is a T-cell malignancy predominantly driven by a hyperactive anaplastic lymphoma kinase (ALK) fusion protein. ALK inhibitors, such as crizotinib, provide alternatives to standard...
Antineoplastic Agents CRISPR-Cas Systems Cell Line Crizotinib Dose-Response Relationship Drug Drug Resistance Neoplasm Gene Editing Gene Expression Humans Immunohistochemistry Interleukin-10 Receptor alpha Subunit Lymphoma Large-Cell Anaplastic Models Biological Nucleophosmin Protein Kinase Inhibitors Protein-Tyrosine Kinases STAT3 Transcription Factor Signal Transduction
Stat3 is required to maintain the full differentiation potential of mammary stem cells and the proliferative potential of mammary luminal progenitors.
Anna D Staniszewska, Sara Pensa, Maria M Caffarel, Lisa H Anderson, Valeria Poli, Christine J Watson
Mar 18, 2021
Stat3 has a defined role in mammary gland where it is a critical mediator of cell death during post-lactational regression. On the other hand, Stat3 is required for the self-renewal of embryonic stem cells and is sufficient for...
Expression of Phosphorylated Signal Transducer and Activator of Transcription 3 and its Prognostic Significance in Canine Anal Sac Adenocarcinoma.
Prognostication in canine anal sac adenocarcinomas (ASACs) is difficult due to conflicting evidence regarding metastatic rates and median survival times (MSTs). The transcription factor signal transducer and activator of...
STAT3 regulated ARF expression suppresses prostate cancer metastasis.
Jan Pencik, Michaela Schlederer, Wolfgang Gruber, Christine Unger, Steven M Walker, Athena Chalaris, Isabelle J Marié, Melanie R Hassler, Tahereh Javaheri, Osman Aksoy, Jaine K Blayney, Nicole Prutsch, Anna Skucha, Merima Herac, Oliver H Krämer, Peter Mazal, Florian Grebien, Gerda Egger, Valeria Poli, Wolfgang Mikulits, Robert Eferl, Harald Esterbauer, Richard Kennedy, Falko Fend, Marcus Scharpf, Martin Braun, Sven Perner, David E Levy, Tim Malcolm, Suzanne D Turner, Andrea Haitel, Martin Susani, Ali Moazzami, Stefan Rose-John, Fritz Aberger, Olaf Merkel, Richard Moriggl, Zoran Culig, Helmut Dolznig, Lukas Kenner
Jun 23, 2015
Overexpression of the oncostatin-M receptor in cervical squamous cell carcinoma is associated with epithelial-mesenchymal transition and poor overall survival.
Justyna A Kucia-Tran, Valtteri Tulkki, Stephen Smith, Cinzia G Scarpini, Katherine Hughes, Angela M Araujo, Ka Yin Matthew Yan, Jan Botthof, Eduardo Pérez-Gómez, Miguel Quintanilla, Kate Cuschieri, Maria M Caffarel, Nicholas Coleman
Jun 23, 2016
Human interleukin-2 receptor β mutations associated with defects in immunity and peripheral tolerance.
Zinan Zhang, Florian Gothe, Perrine Pennamen, John R James, David McDonald, Carlos P Mata, Yorgo Modis, Anas M Alazami, Meghan Acres, Wolfram Haller, Claire Bowen, Rainer Döffinger, Jan Sinclair, Shannon Brothers, Yu Zhang, Helen F Matthews, Sophie Naudion, Fanny Pelluard, Huda Alajlan, Yasuhiro Yamazaki, Luigi D Notarangelo, James E Thaventhiran, Karin R Engelhardt, Hamoud Al-Mousa, Sophie Hambleton, Caroline Rooryck, Kenneth GC Smith, Michael J Lenardo
Jun 24, 2019
Interleukin-2, which conveys essential signals for immunity, operates through a heterotrimeric receptor. Here we identify human interleukin-2 receptor (IL-2R) β chain (IL2RB) gene defects as a cause of life-threatening immune...
Alleles Autoimmunity Genotype HEK293 Cells Humans Immune Tolerance Immunity Immunologic Deficiency Syndromes Interleukin-2 Receptor beta Subunit Killer Cells Natural Lentivirus Mutation Mutation Missense Phenotype Phosphorylation STAT3 Transcription Factor STAT5 Transcription Factor Signal Transduction T-Lymphocytes
STAT3 and TP53 mutations associate with poor prognosis in anaplastic large cell lymphoma.
Cosimo Lobello, Boris Tichy, Vojtech Bystry, Lenka Radova, Daniel Filip, Marek Mraz, Ivonne-Aidee Montes-Mojarro, Nina Prokoph, Hugo Larose, Huan-Chang Liang, Geeta G Sharma, Luca Mologni, David Belada, Katerina Kamaradova, Falko Fend, Carlo Gambacorti-Passerini, Olaf Merkel, Suzanne D Turner, Andrea Janikova, Sarka Pospisilova
Dec 02, 2020
Systemic Anaplastic Large Cell Lymphoma (sALCL) encompasses two distinct clinical entities of T-cell non-Hodgkin lymphoma: Anaplastic Lymphoma Kinase-positive (ALK+) ALCL and ALK-negative (ALK-) ALCL. These entities are...
Stratification and therapeutic potential of PML in metastatic breast cancer.
Natalia Martín-Martín, Marco Piva, Jelena Urosevic, Paula Aldaz, James D Sutherland, Sonia Fernández-Ruiz, Leire Arreal, Verónica Torrano, Ana R Cortazar, Evarist Planet, Marc Guiu, Nina Radosevic-Robin, Stephane Garcia, Iratxe Macías, Fernando Salvador, Giacomo Domenici, Oscar M Rueda, Amaia Zabala-Letona, Amaia Arruabarrena-Aristorena, Patricia Zúñiga-García, Alfredo Caro-Maldonado, Lorea Valcárcel-Jiménez, Pilar Sánchez-Mosquera, Marta Varela-Rey, Maria Luz Martínez-Chantar, Juan Anguita, Yasir H Ibrahim, Maurizio Scaltriti, Charles H Lawrie, Ana M Aransay, Juan L Iovanna, Jose Baselga, Carlos Caldas, Rosa Barrio, Violeta Serra, Maria dM Vivanco, Ander Matheu, Roger R Gomis, Arkaitz Carracedo
Aug 24, 2016
Genetic overlap between endometriosis and endometrial cancer
Jodie N Painter, Tracy A O'Mara, Andrew P Morris, Timothy Ht Cheng, Maggie Gorman, Lynn Martin, Shirley Hodson, Angela Jones, Nicholas G Martin, Scott Gordon, Anjali K Henders, John Attia, Mark McEvoy, Elizabeth G Holliday, Rodney J Scott, Penelope M Webb, Peter A Fasching, Matthias W Beckmann, Arif B Ekici, Alexander Hein, Matthias Rübner, Per Hall, Kamila Czene, Thilo Dörk, Matthias Dürst, Peter Hillemanns, Ingo Runnebaum, Diether Lambrechts, Frederic Amant, Daniela Annibali, Jeroen Depreeuw, Adriaan Vanderstichele, Ellen L Goode, Julie M Cunningham, Sean C Dowdy, Stacey J Winham, Jone Trovik, Erling Hoivik, Henrica MJ Werner, Camilla Krakstad, Katie Ashton, Geoffrey Otton, Tony Proietto, Emma Tham, Miriam Mints, Shahana Ahmed, Catherine S Healey, Mitul Shah, Paul DP Pharoah, Alison M Dunning, Joe Dennis, Manjeet K Bolla, Kyriaki Michailidou, Qin Wang, Jonathan P Tyrer, John L Hopper, Julian Peto, Anthony J Swerdlow, Barbara Burwinkel, Hermann Brenner, Alfons Meindl, Hiltrud Brauch, Annika Lindblom, Jenny Chang-Claude, Fergus J Couch, Graham G Giles, Vessela N Kristensen, Angela Cox, Krina T Zondervan, Dale R Nyholt, Stuart MacGregor, Grant W Montgomery, Ian Tomlinson, Douglas F Easton, Deborah J Thompson, Amanda B Spurdle
May 30, 2018
Epidemiological, biological, and molecular data suggest links between endometriosis and endometrial cancer, with recent epidemiological studies providing evidence for an association between a previous diagnosis of endometriosis...
Cross-disease analysis endometrial cancer endometriosis genetic correlation Genome-Wide Association Study Australia Endometrial Neoplasms endometriosis Endometrium Female Genetic Predisposition to Disease Genome-Wide Association Study Humans Polymorphism Single Nucleotide Receptor-Like Protein Tyrosine Phosphatases Class 2 STAT3 Transcription Factor
Low-dose methotrexate in myeloproliferative neoplasm models.
Kavitha Chinnaiya, Michelle A Lawson, Sally Thomas, Marie-Therese Haider, Jenny Down, Andrew D Chantry, David Hughes, Antony Green, Jon R Sayers, John A Snowden, Martin P Zeidler
Nov 23, 2017
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