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Schwann Cells adult CNS progenitors neuroscience perivascular niche rat remyelination Animals Astrocytes Bone Morphogenetic Proteins Cell Differentiation Cellular Microenvironment Central Nervous System Demyelinating Diseases Endothelial Cells Gene Expression Regulation Ligands Oligodendroglia Peripheral Nervous System RNA Messenger Rats Stem Cell Niche Stem Cells Wnt Signaling Pathway Wounds and Injuries

Charcot-Marie-Tooth disease Peripheral neuropathy Schwann Cells Animals Carrier Proteins Cells Cultured Charcot-Marie-Tooth Disease Gene Expression HeLa Cells Humans Integrin alpha6 Myelin Sheath Phylogeny Rats Schwann Cells rab GTP-Binding Proteins

The class IIa histone deacetylases (HDACs) have pivotal roles in the development of different tissues. Of this family, Schwann cells express Hdac4, 5 and 7 but not Hdac9. Here we show that a transcription factor regulated...

RESEARCH ARTICLE Cell Biology neuroscience myelin Schwann Cells class II HDACs gene compensation nerve development Nerve Regeneration MOUSE rat

Schwann cell grafts support axonal growth following spinal cord injury, but a boundary forms between the implanted cells and host astrocytes. Axons are reluctant to exit the graft tissue in large part due to the surrounding...

Animals Astrocytes Axons Cell Adhesion Cell Movement Cells Cultured Central Nervous System Chondroitin ABC Lyase Chondroitin Sulfate Proteoglycans Female Genetic Therapy Integrins Lentivirus Nerve Regeneration Neurites Neuroglia Neurons Peripheral Nervous System Rats Rats Sprague-Dawley Schwann Cells Spinal Cord Injuries

After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that...

aging c-Jun chronic denervation MOUSE Nerve Regeneration neuroscience Regenerative Medicine repair cell Schwann cell Stem Cells aging Animals Female Male Mice Nerve Regeneration Proto-Oncogene Proteins c-jun Schwann Cells

The class IIa histone deacetylases (HDACs) have pivotal roles in the development of different tissues. Of this family, Schwann cells express Hdac4, 5 and 7 but not Hdac9. Here we show that a transcription factor regulated...

Schwann Cells Cell Biology class II HDACs gene compensation MOUSE myelin nerve development Nerve Regeneration neuroscience rat Animals Female Gene Expression Regulation Genes jun Histone Deacetylases MEF2 Transcription Factors Male Mice Peripheral Nerves remyelination Schwann Cells

To investigate the function of laminins in peripheral nerve development, the laminin γ1 gene was specifically disrupted in Schwann cells. Disruption of laminin γ1 gene expression resulted in depletion of all other laminin...

Schwann Cells laminin y1 gene nerve development Life Sciences

CNS remyelination Foxj1 Schwann Cells peripheral nerve Animals Central Nervous System Female Forkhead Transcription Factors Gene Expression Male Mice Mice Inbred C57BL Mice Transgenic Myelin Sheath Peripheral Nervous System remyelination Schwann Cells Sciatic Nerve Spinal Cord

Mutations in the GJB1 gene, encoding the gap junction (GJ) protein connexin32 (Cx32), cause X-linked Charcot-Marie-Tooth disease (CMT1X), an inherited demyelinating neuropathy. We developed a gene therapy approach for CMT1X...

Animals Charcot-Marie-Tooth disease connexins Genetic Therapy Mice Mice Knockout Schwann Cells Tissue Distribution

HDACs HDACs therapies Schwann cell Ageing myelin nerve injury Nerve Regeneration remyelination repair Schwann cell Axons Histone Deacetylases Histones Nerve Regeneration Peripheral Nervous System Schwann Cells

DNA methylation is one of many epigenetic marks, which directly modifies base residues, usually cytosines, in a multiple-step cycle. It has been linked to the regulation of gene expression and alternative splicing in several...

DNA Methylation Schwann cell Schwannomas aging Demyelination epigenetics glioma oligodendrocyte Animals Cell Differentiation Cell Lineage Humans Myelin Sheath Neuroglia Oligodendroglia Schwann Cells

Schwann Cells adaptive reprogramming c-Jun Epithelial-Mesenchymal Transition nerve injury Nerve Regeneration repair cells Animals Axons Disease Models Animal Epithelial-Mesenchymal Transition Myelin Sheath Nerve Regeneration Neuronal Plasticity Schwann Cells

Animals Astrocytes Cells Cultured Central Nervous System Demyelinating Diseases Mice Knockout Myelin Sheath Nerve Regeneration Neuroglia Oligodendroglia STAT3 Transcription Factor Schwann Cells Stem Cells

Schwann Cells Androgen receptor myelin Oligodendrocytes Testosterone

Schwann Cells Astrocytes Central Nervous System myelin oligodendrocyte progenitor cells remyelination Cell Differentiation Central Nervous System Humans Multiple Sclerosis Myelin Sheath Oligodendroglia remyelination Schwann Cells Stem Cells