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Cover Image for De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints. View Article
De Novo Evolutionary Emergence of a Symmetrical Protein Is Shaped by Folding Constraints.
Robert G Smock, Itamar Yadid, Orly Dym, Jane Clarke, Dan S Tawfik
Jan 08, 2016
Amino Acid Motifs Amino Acid Sequence Animals Arthropod Proteins evolution Molecular Gene Duplication Horseshoe Crabs Lectins Models Molecular Molecular Sequence Data Phylogeny Protein Folding Sea Anemones Sequence Alignment
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Cover Image for Modular Pore-Forming Immunotoxins with Caged Cytotoxicity Tailored by Directed Evolution. View Article
Modular Pore-Forming Immunotoxins with Caged Cytotoxicity Tailored by Directed Evolution.
Natalie L Mutter, Misha Soskine, Gang Huang, Inês S Albuquerque, Gonçalo JL Bernardes, Giovanni Maglia
Dec 04, 2018
Immunotoxins are proteins containing a cell-targeting element linked to a toxin that are under investigation for next-generation cancer treatment. However, these agents are difficult to synthesize, chemically heterogeneous...
Animals Cell Line Tumor Cell Membrane Cnidarian Venoms Directed Molecular Evolution Drug Design Escherichia coli Folic Acid Furin Humans Immunotoxins Mutagenesis Pore Forming Cytotoxic Proteins Proteolysis Recombinant Fusion Proteins Salmonella typhi Sea Anemones Tetrahydrofolate Dehydrogenase
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