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Results: 31
Connectomics Analysis Reveals First-, Second-, and Third-Order Thermosensory and Hygrosensory Neurons in the Adult Drosophila Brain.
Elizabeth C Marin, Laurin Büld, Maria Theiss, Tatevik Sarkissian, Ruairí JV Roberts, Robert Turnbull, Imaan FM Tamimi, Markus W Pleijzier, Willem J Laursen, Nik Drummond, Philipp Schlegel, Alexander S Bates, Feng Li, Matthias Landgraf, Marta Costa, Davi D Bock, Paul A Garrity, Gregory SXE Jefferis
Jun 10, 2020
Expression of the amyloid-β peptide in a single pair of C. elegans sensory neurons modulates the associated behavioural response.
Tessa Sinnige, Prashanth Ciryam, Samuel Casford, Christopher M Dobson, Mario de Bono, Michele Vendruscolo
Jun 20, 2019
5-oxoETE triggers nociception in constipation-predominant irritable bowel syndrome through MAS-related G protein-coupled receptor D.
Tereza Bautzova, James RF Hockley, Teresa Perez-Berezo, Julien Pujo, Michael M Tranter, Cleo Desormeaux, Maria Raffaella Barbaro, Lilian Basso, Pauline Le Faouder, Corinne Rolland, Pascale Malapert, Aziz Moqrich, Helene Eutamene, Alexandre Denadai-Souza, Nathalie Vergnolle, Ewan St John Smith, David I Hughes, Giovanni Barbara, Gilles Dietrich, David C Bulmer, Nicolas Cenac
Jan 04, 2019
Receptor-type Guanylyl Cyclases Confer Thermosensory Responses in C. elegans.
Asuka Takeishi, Yanxun V Yu, Vera M Hapiak, Harold W Bell, Timothy O'Leary, Piali Sengupta
Feb 23, 2016
Decoding the intensity of sensory input by two glutamate receptors in one C. elegans interneuron.
Wenjuan Zou, Jiajun Fu, Haining Zhang, Kang Du, Wenming Huang, Junwei Yu, Shitian Li, Yuedan Fan, Howard A Baylis, Shangbang Gao, Rui Xiao, Wei Ji, Lijun Kang, Tao Xu
Nov 30, 2018
How neurons are capable of decoding stimulus intensity and translate this information into complex behavioral outputs is poorly defined. Here, we demonstrate that the C. elegans interneuron AIB regulates two types of behaviors...
Identification of genes influencing dendrite morphogenesis in developing peripheral sensory and central motor neurons.
Metamorphosis of an identified serotonergic neuron in the Drosophila olfactory system.
Bidisha Roy, Ajeet P Singh, Chetak Shetty, Varun Chaudhary, Annemarie North, Matthias Landgraf, K Vijayraghavan, Veronica Rodrigues
Jun 16, 2011
Animals Cell Differentiation Cell Shape Central Nervous System Dendrites Drosophila Proteins Drosophila melanogaster Ecdysterone Feedback Growth Cones Image Cytometry Larva Metamorphosis Biological Microtubule-Associated Proteins Mushroom Bodies Nerve Net Neuronal Plasticity Olfactory Pathways Receptors Steroid Sensory Receptor Cells Serotonin Smell
Role of Human Mesenchymal Stem Cells and Derived Extracellular Vesicles in Reducing Sensory Neuron Hyperexcitability and Pain Behaviors in Murine Osteoarthritis.
Minji Ai, William E Hotham, Luke A Pattison, Qingxi Ma, Frances MD Henson, Ewan St John Smith
Jan 04, 2023
Development of connectivity in a motoneuronal network in Drosophila larvae.
Louise Couton, Alex S Mauss, Temur Yunusov, Soeren Diegelmann, Jan Felix Evers, Matthias Landgraf
Mar 24, 2015
Drosophila Ionotropic Receptor 25a mediates circadian clock resetting by temperature.
Chenghao Chen, Edgar Buhl, Min Xu, Vincent Croset, Johanna S Rees, Kathryn S Lilley, Richard Benton, James JL Hodge, Ralf Stanewsky
Jan 21, 2016
Generation and characterization of an Advillin-Cre driver mouse line.
Sandra Zurborg, Agnieszka Piszczek, Conception Martínez, Philip Hublitz, Mumna Al Banchaabouchi, Pedro Moreira, Emerald Perlas, Paul A Heppenstall
Aug 08, 2017
Progress in the somatosensory field has been restricted by the limited number of genetic tools available to study gene function in peripheral sensory neurons. Here we generated a Cre-driver mouse line that expresses...
Human Labor Pain Is Influenced by the Voltage-Gated Potassium Channel KV6.4 Subunit.
Michael C Lee, Michael S Nahorski, James RF Hockley, Van B Lu, Gillian Ison, Luke A Pattison, Gerard Callejo, Kaitlin Stouffer, Emily Fletcher, Christopher Brown, Ichrak Drissi, Daniel Wheeler, Patrik Ernfors, David Menon, Frank Reimann, Ewan St John Smith, C Geoffrey Woods
Jul 02, 2020
labor pain nociception Pain Kv6.4 quantitative sensory testing DRG neuron exome sequencing Adult Alleles Amino Acid Sequence Analgesics Animals Base Sequence Cell Membrane Cognition Cohort Studies Emotions Female Ganglia Spinal Heterozygote Humans Ion Channel Gating Labor Pain Male Mice Inbred C57BL Models Biological Mutation Nociceptors Pain Threshold Polymorphism Single Nucleotide Potassium Channels Voltage-Gated Pregnancy Protein Multimerization Protein Subunits Sensory Receptor Cells Shab Potassium Channels Subcellular Fractions Uterus
Unveiling the sensory and interneuronal pathways of the neuroendocrine connectome in Drosophila.
Sebastian Hückesfeld, Philipp Schlegel, Anton Miroschnikow, Andreas Schoofs, Ingo Zinke, André N Haubrich, Casey M Schneider-Mizell, James W Truman, Richard D Fetter, Albert Cardona, Michael J Pankratz
Aug 09, 2021
Neuroendocrine systems in animals maintain organismal homeostasis and regulate stress response. Although a great deal of work has been done on the neuropeptides and hormones that are released and act on target organs in the...
D. melanogaster Carbon Dioxide Connectome interneuron neuroendocrine system Neuropeptides neuroscience sensory synapses Animals Animals Genetically Modified Carbon Dioxide Connectome Drosophila Proteins Drosophila melanogaster Insect Hormones Interneurons Microscopy Electron Transmission Neuropeptides Neurosecretory Systems Sensory Receptor Cells Synapses
A 3.7 kb fragment of the mouse Scn10a gene promoter directs neural crest but not placodal lineage EGFP expression in a transgenic animal.
dorsal root ganglia nodose ganglion Pain Sodium Channels transgenic Animals Cell Lineage Female Gene Expression Regulation Developmental Green Fluorescent Proteins Male Mice Mice Transgenic NAV1.8 Voltage-Gated Sodium Channel Nerve Fibers Myelinated Neural Crest Neural Stem Cells Neurogenesis Organ Specificity Promoter Regions Genetic Sensory Receptor Cells
Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner.
Sampurna Chakrabarti, Luke A Pattison, Kaajal Singhal, James RF Hockley, Gerard Callejo, Ewan St John Smith
Nov 17, 2018
Digging behavior dorsal root ganglion neurons Inflammation Joint pain sensitization TRPV1 Animals Anti-Inflammatory Agents Non-Steroidal Arthralgia Capsaicin Cells Cultured Disease Models Animal Female Freund's Adjuvant Ganglia Spinal Hindlimb Inflammation Isoquinolines Mice Inbred C57BL Motor Activity Receptor trkA Sensory Receptor Cells TRPV Cation Channels Urea gamma-Aminobutyric Acid
The contribution of TRPM8 and TRPA1 channels to cold allodynia and neuropathic pain.
Cold allodynia is a common feature of neuropathic pain however the underlying mechanisms of this enhanced sensitivity to cold are not known. Recently the transient receptor potential (TRP) channels TRPM8 and TRPA1 have been...
Achieving functional neuronal dendrite structure through sequential stochastic growth and retraction.
André Ferreira Castro, Lothar Baltruschat, Tomke Stürner, Amirhoushang Bahrami, Peter Jedlicka, Gaia Tavosanis, Hermann Cuntz
Feb 08, 2021
Class I ventral posterior dendritic arborisation (c1vpda) proprioceptive sensory neurons respond to contractions in the Drosophila larval body wall during crawling. Their dendritic branches run along the direction of...
D. melanogaster computer model dendrite function dendrite growth dendrite retraction developmental biology Mechanotransduction neuroscience self-organisation Animals Animals Genetically Modified Dendrites Drosophila Drosophila Proteins Gene Expression Regulation Developmental Green Fluorescent Proteins Morphogenesis Sensory Receptor Cells
Advances in understanding nociception and neuropathic pain.
Ewan St John Smith
Nov 28, 2018
Pain results from the activation of a subset of sensory neurones termed nociceptors and has evolved as a "detect and protect" mechanism. However, lesion or disease in the sensory system can result in neuropathic pain, which...
Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity
C Wetzel, S Pifferi, C Picci, C Gök, D Hoffmann, KK Bali, A Lampe, L Lapatsina, R Fleischer, ESJ Smith, V Bégay, M Moroni, L Estebanez, J Kühnemund, J Walcher, E Specker, M Neuenschwander, JP von Kries, V Haucke, R Kuner, JFA Poulet, J Schmoranzer, K Poole, GR Lewin
Jan 30, 2017
Single-cell RNAseq reveals seven classes of colonic sensory neuron.
James RF Hockley, Toni S Taylor, Gerard Callejo, Anna L Wilbrey, Alex Gutteridge, Karsten Bach, Wendy J Winchester, David C Bulmer, Gordon McMurray, Ewan St John Smith
Apr 27, 2018
OBJECTIVE: Integration of nutritional, microbial and inflammatory events along the gut-brain axis can alter bowel physiology and organism behaviour. Colonic sensory neurons activate reflex pathways and give rise to conscious...
Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts.
Jennifer N Dulin, Andrew F Adler, Hiromi Kumamaru, Gunnar HD Poplawski, Corinne Lee-Kubli, Hans Strobl, Daniel Gibbs, Ken Kadoya, James W Fawcett, Paul Lu, Mark H Tuszynski
May 10, 2018
Neural progenitor cell (NPC) transplantation has high therapeutic potential in neurological disorders. Functional restoration may depend on the formation of reciprocal connections between host and graft. While it has been...
Dorsal Root Ganglion Injection and Dorsal Root Crush Injury as a Model for Sensory Axon Regeneration.
Achieving axon regeneration after nervous system injury is a challenging task. As different parts of the central nervous system (CNS) differ from each other anatomically, it is important to identify an appropriate model to use...
Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response.
Nicholas O Burton, Vivek K Dwivedi, Kirk B Burkhart, Rebecca EW Kaplan, L Ryan Baugh, H Robert Horvitz
Feb 11, 2019
Insulin and insulin-like signaling regulates a broad spectrum of growth and metabolic responses to a variety of internal and environmental stimuli. For example, the inhibition of insulin-like signaling in C. elegans mediates its...
Animals Caenorhabditis elegans Caenorhabditis elegans Proteins Cloning Molecular Embryo Nonmammalian Embryonic Development Forkhead Transcription Factors Gene Expression Regulation Developmental Insulin Lysophosphatidylcholines Mutagenesis Nerve Tissue Proteins Neurotransmitter Agents Osmotic Pressure RNA Messenger Receptor Insulin Receptors Cytoplasmic and Nuclear Sensory Receptor Cells Signal Transduction Starvation Stress Physiological Sulfotransferases
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