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Results: 95
In vivo measurement of the effective atomic number of breast skin using spectral mammography.
X-ray characteristics of body tissues are of crucial importance for developing and optimizing x-ray imaging techniques, in particular for dosimetry and spectral imaging applications. For breast imaging, the most important...
Protein aggregation of the p63 transcription factor underlies severe skin fragility in AEC syndrome.
Claudia Russo, Christian Osterburg, Anna Sirico, Dario Antonini, Raffaele Ambrosio, Julia Maren Würz, Jörg Rinnenthal, Marco Ferniani, Sebastian Kehrloesser, Birgit Schäfer, Peter Güntert, Satrajit Sinha, Volker Dötsch, Caterina Missero
Aug 31, 2018
AEC syndrome mouse model p63 protein aggregation Skin Animals Cleft Lip Cleft Palate Ectoderm Eye Abnormalities Frameshift Mutation HEK293 Cells Heterozygote Humans Mice Mutation Mutation Missense Phosphoproteins Protein Binding Protein Denaturation Skin Trans-Activators Transcription Factors Transcription Genetic Tumor Suppressor Proteins
Observations on the inconsistency of dermatome maps and its effect on knowledge and confidence in clinical students.
Dermatomes are an important component of medical curricula and clinical practice. In addition to the intrinsic complexity of dermatome maps, their discrepancies in the literature make their learning among students even more...
Mechanisms of stretch-mediated skin expansion at single-cell resolution.
Mariaceleste Aragona, Alejandro Sifrim, Milan Malfait, Yura Song, Jens Van Herck, Sophie Dekoninck, Souhir Gargouri, Gaëlle Lapouge, Benjamin Swedlund, Christine Dubois, Pieter Baatsen, Katlijn Vints, Seungmin Han, Fadel Tissir, Thierry Voet, Benjamin D Simons, Cédric Blanpain
Jun 09, 2020
Adaptor Proteins Signal Transducing Adherens Junctions Animals Base Sequence Cell Cycle Proteins Cell Differentiation Cell Self Renewal Chromatin Chromatin Assembly and Disassembly Clone Cells Disease Models Animal Extracellular Signal-Regulated MAP Kinases Gene Regulatory Networks Hydrogels Mechanotransduction Cellular Mice Mice Transgenic Mitogen-Activated Protein Kinase Kinases Mutation RNA Messenger RNA-seq Single-Cell Analysis Skin Stem Cells Trans-Activators Transcription Factor AP-1 Transcription Genetic YAP-Signaling Proteins
Reprogramming Human Adult Fibroblasts into GABAergic Interneurons.
Andreas Bruzelius, Srisaiyini Kidnapillai, Janelle Drouin-Ouellet, Tom Stoker, Roger A Barker, Daniella Rylander Ottosson
Jan 28, 2022
Direct reprogramming is an appealing strategy to generate neurons from a somatic cell by forced expression of transcription factors. The generated neurons can be used for both cell replacement strategies and disease modelling....
adult skin cells calbindin direct reprogramming disease-modelling Electrophysiology iN neuronal conversion Adult Brain Diseases Cell Differentiation Cellular Reprogramming Cognitive Dysfunction FIBROBLASTS GABAergic Neurons Gene Expression Regulation Humans Interneurons Neurogenesis Neuroglia Repressor Proteins Skin gamma-Aminobutyric Acid
Development and<i> in vitro</i> evaluation of lipid nanoparticle-based dressings for topical treatment of chronic wounds
G. Gainza, W. S. Chu, R. H. Guy, J. L. Pedraz, R. M. Hernandez, B. Delgado-Charro, M. Igartua
Jul 25, 2015
This research addresses the development and in vitro evaluation of lipid nanoparticle (NP)-based dressings to optimize the delivery of human recombinant epidermal growth factor (rhEGF) for the topical treatment of chronic...
A mechanistic approach to modelling the formation of a drug reservoir in the skin
It has been shown that prolonged systemic presence of a drug can cause a build-up of that drug in the skin. This drug ‘reservoir’, if properly understood, could provide useful information about recent drug-taking history of...
Disseminated $\textit{Mycobacterium malmoense}$ and $\textit{Salmonella}$ Infections Associated with a Novel Variant in $\textit{NFKBIA}$
E Staples, B Morillo-Gutierrez, J Davies, D Petersheim, M Massaad, M Slatter, D Dimou, R Doffinger, S Hackett, D Kumararatne, J Hadfield, MD Eldridge, RS Geha, M Abinun, JED Thaventhiran
May 05, 2017
JEDT is supported by a MRC Clinician Scientist Fellowship (MR/L006197/1). This work has been funded by BRC III PPG funding and by grant number 1R21AI124101-01 “Mechanisms of disease in patients with IκBα mutations” in RG’s...
Human dermal CD14⁺ cells are a transient population of monocyte-derived macrophages.
Naomi McGovern, Andreas Schlitzer, Merry Gunawan, Laura Jardine, Amanda Shin, Elizabeth Poyner, Kile Green, Rachel Dickinson, Xiao-Nong Wang, Donovan Low, Katie Best, Samuel Covins, Paul Milne, Sarah Pagan, Khadija Aljefri, Martin Windebank, Diego Miranda-Saavedra, Anis Larbi, Pavandip Singh Wasan, Kaibo Duan, Michael Poidinger, Venetia Bigley, Florent Ginhoux, Matthew Collin, Muzlifah Haniffa
Jun 18, 2018
Dendritic cells (DCs), monocytes, and macrophages are leukocytes with critical roles in immunity and tolerance. The DC network is evolutionarily conserved; the homologs of human tissue CD141(hi)XCR1⁺ CLEC9A⁺ DCs and CD1c⁺ DCs...
Glycolysis inhibition improves photodynamic therapy response rates for equine sarcoids.
Photodynamic therapy (PDT) holds great promise in treating veterinary and human dermatological neoplasms, including equine sarcoids, but is currently hindered by the amount of photosensitiser and light that can be delivered to...
Paging through history
MD Teasdale, NL van Doorn, S Fiddyment, CC Webb, T O'Connor, M Hofreiter, MJ Collins, DG Bradley
Nov 22, 2018
Parchment represents an invaluable cultural reservoir. Retrieving an additional layer of information from these abundant, dated livestock-skins via the use of ancient DNA (aDNA) sequencing has been mooted by a number of...
Alkaline ceramidase 1 is essential for mammalian skin homeostasis and regulating whole-body energy expenditure.
Kifayathullah Liakath-Ali, Valerie E Vancollie, Christopher J Lelliott, Anneliese O Speak, David Lafont, Hayley J Protheroe, Camilla Ingvorsen, Antonella Galli, Angela Green, Diane Gleeson, Ed Ryder, Leanne Glover, Gema Vizcay-Barrena, Natasha A Karp, Mark J Arends, Thomas Brenn, Sarah Spiegel, David J Adams, Fiona M Watt, Louise van der Weyden
Feb 18, 2021
The epidermis is the outermost layer of skin that acts as a barrier to protect the body from the external environment and to control water and heat loss. This barrier function is established through the multistage...
ceramidase Energy homeostasis Sebaceous Glands skin homeostasis Alkaline Ceramidase Alopecia Animals Cell Differentiation Ceramides Energy Metabolism epidermis Female Hair Follicle Homeostasis Humans Keratinocytes Male Mice Mice Inbred C57BL Pituitary Gland Sebaceous Glands Skin Skin Abnormalities sphingolipids
Imaging drug delivery to skin with stimulated Raman scattering microscopy
Efficient drug delivery to the skin is essential for the treatment of major dermatologic diseases, such as eczema, psoriasis and acne. However, many compounds penetrate the skin barrier poorly and require optimized formulations...
EEG central sensitization intraepidermal electrical stimulation mechanical punctate stimulation secondary hyperalgesia Adult Afferent Pathways Brain Capsaicin Central Nervous System Sensitization Electric Stimulation Electroencephalography Evoked Potentials Somatosensory Female Humans Hyperalgesia Male Nociceptors Pain Pain Measurement ROC Curve Reaction Time Signal-To-Noise Ratio Skin Young Adult
Automation and validation of micronucleus detection in the 3D EpiDerm™ human reconstructed skin assay and correlation with 2D dose responses.
Recent restrictions on the testing of cosmetic ingredients in animals have resulted in the need to test the genotoxic potential of chemicals exclusively in vitro prior to licensing. However, as current in vitro tests produce...
Murine HPV16 E7-expressing transgenic skin effectively emulates the cellular and molecular features of human high-grade squamous intraepithelial lesions.
Currently available vaccines prevent HPV infection and development of HPV-associated malignancies, but do not cure existing HPV infections and dysplastic lesions. Persistence of infection(s) in immunocompetent patients may...
Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk.
Liam D Cassidy, Andrew RJ Young, Christopher NJ Young, Elizabeth J Soilleux, Edward Fielder, Bettina M Weigand, Anthony Lagnado, Rebecca Brais, Nicholas T Ktistakis, Kimberley A Wiggins, Katerina Pyrillou, Murray CH Clarke, Diana Jurk, Joao F Passos, Masashi Narita
Dec 20, 2019
Algorithm based smartphone apps to assess risk of skin cancer in adults
Karoline Freeman, Jacqueline Dinnes, Naomi Chuchu, Yemisi Takwoingi, Sue E Bayliss, Rubeta N Matin, Abhilash Jain, Fiona M Walter, Hywel C Williams, Jonathan J Deeks
Feb 21, 2020
OBJECTIVE: To examine the validity and findings of studies that examine the accuracy of algorithm based smartphone applications ("apps") to assess risk of skin cancer in suspicious skin lesions. DESIGN: Systematic review of...
Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation.
Ricardo J Miragaia, Tomás Gomes, Agnieszka Chomka, Laura Jardine, Angela Riedel, Ahmed N Hegazy, Natasha Whibley, Andrea Tucci, Xi Chen, Ida Lindeman, Guy Emerton, Thomas Krausgruber, Jacqueline Shields, Muzlifah Haniffa, Fiona Powrie, Sarah A Teichmann
Mar 05, 2019
Non-lymphoid tissues (NLTs) harbor a pool of adaptive immune cells with largely unexplored phenotype and development. We used single-cell RNA-seq to characterize 35,000 CD4+ regulatory (Treg) and memory (Tmem) T cells in mouse...
Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis.
Tamara Muliaditan, Jonathan Caron, Mary Okesola, James W Opzoomer, Paris Kosti, Mirella Georgouli, Peter Gordon, Sharanpreet Lall, Desislava M Kuzeva, Luisa Pedro, Jacqueline D Shields, Cheryl E Gillett, Sandra S Diebold, Victoria Sanz-Moreno, Tony Ng, Esther Hoste, James N Arnold
Nov 06, 2018
Tumour-associated macrophages (TAMs) play an important role in tumour progression, which is facilitated by their ability to respond to environmental cues. Here we report, using murine models of breast cancer, that TAMs...
Animals Breast Neoplasms Cell Line Tumor Cell Survival Collagen Cytokines Endopeptidases Female Gelatinases Gene Expression Regulation Neoplastic Heme Oxygenase-1 Humans Interleukin-6 MACROPHAGES Membrane Proteins Mice Mice Inbred BALB C Mice Mutant Strains Neoplasm Metastasis Phenotype Prognosis Serine Endopeptidases Skin Tumor Microenvironment Wound Healing
An in vivo tethered toxin approach for the cell-autonomous inactivation of voltage-gated sodium channel currents in nociceptors
ESJ Smith, AS Stürzebecher, J Hu, S Frahm, J Santos-Torres, B Kampfrath, S Auer, GR Lewin, I Ibanez-Tallon
Aug 11, 2017
Animals Behavior Animal Blotting Southern Chromosomes Artificial Bacterial Conotoxins DNA Electrophysiology Female Immunohistochemistry In Situ Hybridization Ion Channel Gating Mice Mice Transgenic Neurons Afferent Nociceptors Oocytes Pain Patch-Clamp Techniques Reverse Transcriptase Polymerase Chain Reaction Skin Sodium Channel Blockers Sodium Channels Spinal Cord Xenopus laevis
Decoding acute pain with combined EEG and physiological data
Across neuroscience research, clinical diagnostics, and engineering applications in pain evaluation and treatment, there is a need for an objective measure of pain experience and detection when it occurs. This detector should be...
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