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Use of CSF infusion studies to unblock occluded hydrocephalus ventricular shunt catheters
Two patients with ventriculoperitoneal shunts presented with symptoms of raised intracranial pressure indicative of possible shunt malfunction. During investigation, to eliminate this possibility, cerebral spinal fluid infusion...
Neuro-mesodermal progenitors (NMPs)
The mammalian embryo's caudal lateral epiblast (CLE) harbours bipotent progenitors, called neural mesodermal progenitors (NMPs), that contribute to the spinal cord and the paraxial mesoderm throughout axial elongation. Here, we...
neuromesodermal progenitors Single cells Transcription Animals Body Patterning Cell Differentiation Cell Lineage Embryo Mammalian Embryonic Stem Cells Female Gene Expression Profiling Gene Expression Regulation Developmental Germ Layers Green Fluorescent Proteins In Vitro Techniques Male Mesoderm Mice Neural Stem Cells Pluripotent Stem Cells Spinal Cord Stem Cells Support Vector Machine Transcriptome
A modified prebind engagement process reduces biomechanical loading on front row players during scrummaging
Aims: Biomechanical studies of the rugby union scrum have typically been conducted using instrumented scrum machines, but a large-scale biomechanical analysis of live contested scrummaging is lacking. We investigated whether the...
Changes in functional properties and 5-HT modulation above and below a spinal transection in lamprey.
Automatic contour propagation using deformable image registration to determine delivered dose to spinal cord in head-and-neck cancer radiotherapy.
PL Yeap, DJ Noble, K Harrison, AM Bates, NG Burnet, R Jena, M Romanchikova, MPF Sutcliffe, SJ Thomas, GC Barnett, RJ Benson, SJ Jefferies, MA Parker
Jun 27, 2017
Expression of an Activated Integrin Promotes Long-Distance Sensory Axon Regeneration in the Spinal Cord.
Menghon Cheah, Melissa R Andrews, Daniel J Chew, Elizabeth B Moloney, Joost Verhaagen, Reinhard Fässler, James W Fawcett
Sep 03, 2019
UNLABELLED: After CNS injury, axon regeneration is blocked by an inhibitory environment consisting of the highly upregulated tenascin-C and chondroitin sulfate proteoglycans (CSPGs). Tenascin-C promotes growth of axons if they...
adeno-associated virus alpha9 integrin Axon regeneration dorsal root ganglion kindlin-1 Spinal Cord Animals Axons Calcitonin Gene-Related Peptide Cells Cultured Chondroitin Sulfate Proteoglycans Disease Models Animal Female Functional Laterality Ganglia Spinal Gene Expression Regulation Integrins Nerve Regeneration Nerve Tissue Proteins Neurites Pressure Rats Rats Sprague-Dawley Spinal Cord Spinal Cord Injuries Walking
The Chick Caudolateral Epiblast Acts as a Permissive Niche for Generating Neuromesodermal Progenitor Behaviours.
PPG neurons in the nucleus of the solitary tract modulate heart rate but do not mediate GLP-1 receptor agonist-induced tachycardia in mice.
Marie K Holt, Daniel R Cook, Daniel I Brierley, James E Richards, Frank Reimann, Alexander V Gourine, Nephtali Marina, Stefan Trapp
Jun 01, 2020
OBJECTIVE: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are used as anti-diabetic drugs and are approved for obesity treatment. However, GLP-1RAs also affect heart rate (HR) and arterial blood pressure (ABP) in rodents...
Biotelemetry cardiovascular function Chemogenetics GLP-1 PPG neurons Sympathetic outflow Animals Disease Models Animal Electrocardiography Exenatide Glucagon-Like Peptide-1 Receptor Heart Rate Mice Mice Transgenic Neurons Proglucagon Solitary Nucleus Spinal Cord sympathetic nervous system Tachycardia
Enrichment of human embryonic stem cell-derived V3 interneurons using an Nkx2-2 gene-specific reporter.
Ieva Berzanskyte, Federica Riccio, Carolina Barcellos Machado, Elizabeth J Bradbury, Ivo Lieberam
Feb 03, 2023
V3 spinal interneurons are a key element of the spinal circuits, which control motor function. However, to date, there are no effective ways of deriving a pure V3 population from human pluripotent stem cells. Here, we report a...
Short-Term Synaptic Plasticity at Interneuronal Synapses Could Sculpt Rhythmic Motor Patterns.
neuronal network rhythmic Spinal Cord synaptic depression synaptic plasticity Animals biophysics Calcium Electric Stimulation Excitatory Amino Acids Excitatory Postsynaptic Potentials Feedback Physiological Functional Laterality In Vitro Techniques Interneurons Lampreys Locomotion Models Neurological Motor Neurons N-Methylaspartate Nerve Net Neuronal Plasticity Periodicity Spinal Cord Synapses alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
An in vivo tethered toxin approach for the cell-autonomous inactivation of voltage-gated sodium channel currents in nociceptors
ESJ Smith, AS Stürzebecher, J Hu, S Frahm, J Santos-Torres, B Kampfrath, S Auer, GR Lewin, I Ibanez-Tallon
Aug 11, 2017
Animals Behavior Animal Blotting Southern Chromosomes Artificial Bacterial Conotoxins DNA Electrophysiology Female Immunohistochemistry In Situ Hybridization Ion Channel Gating Mice Mice Transgenic Neurons Afferent Nociceptors Oocytes Pain Patch-Clamp Techniques Reverse Transcriptase Polymerase Chain Reaction Skin Sodium Channel Blockers Sodium Channels Spinal Cord Xenopus laevis
A Review of the Segmental Diameter of the Healthy Human Spinal Cord.
Knowledge of the average size and variability of the human spinal cord can be of importance when treating pathological conditions in the spinal cord. Data on healthy human spinal cord morphometrics have been published for more...
Identification of the extracellular matrix protein Fibulin-2 as a regulator of spinal nerve organization.
During amniote peripheral nervous system development, segmentation ensures the correct patterning of the spinal nerves relative to the vertebral column. Along the antero-posterior (rostro-caudal) axis, each somite-derived...
The EIIIA domain from astrocyte-derived fibronectin mediates proliferation of oligodendrocyte progenitor cells following CNS demyelination.
astrocyte Fibronectin Multiple Sclerosis oligodendrocyte remyelination Animals Basic Helix-Loop-Helix Transcription Factors Cell Adhesion Cell Differentiation Cell Movement Cell Proliferation Demyelinating Diseases Disease Models Animal Fibronectins Glial Fibrillary Acidic Protein Homeobox Protein Nkx-2.2 Homeodomain Proteins Humans Ki-67 Antigen Lysophosphatidylcholines Mice Mice Knockout Nerve Regeneration Nerve Tissue Proteins Oligodendrocyte Transcription Factor 2 Oligodendroglia SOXB1 Transcription Factors Spinal Cord Stem Cells Transcription Factors Zebrafish Proteins
Assessing Sox2 Expression in the Spinal Cord of Ambystoma mexicanum During Single and Multiple Regeneration Periods
Adam G Dykie
Jan 01, 0001
A major participant in neural regeneration is the transcription factor Sox2. It is expressed in neural stem cells, likely contributing to central nervous system restoration. The axolotl, Ambystoma mexicanum, exhibits extensive...
Published by: Ursinus College
Unravelling the enigma of selective vulnerability in neurodegeneration
Alice Brockington, Ke Ning, Paul R Heath, Elizabeth Wood, Janine Kirby, Nicolò Fusi, Neil Lawrence, Stephen B Wharton, Paul G Ince, Pamela J Shaw
Jan 14, 2020
A consistent clinical feature of amyotrophic lateral sclerosis (ALS) is the sparing of eye movements and the function of external sphincters, with corresponding preservation of motor neurons in the brainstem oculomotor nuclei...
Synaptic Variability Introduces State-Dependent Modulation of Excitatory Spinal Cord Synapses.
David Parker
Oct 03, 2017
Presynaptic control of transmission through group II muscle afferents in the midlumbar and sacral segments of the spinal cord is independent of corticospinal control.
Transmission of information from the terminals group II muscle afferents is subject to potent presynaptic modulation by both segmental group II and cutaneous afferents and by descending monoaminergic systems. Currently it is...
Afferent Pathways Electric Stimulation Excitatory Postsynaptic Potentials Inhibitory Postsynaptic Potentials Lumbar Vertebrae Motor Cortex Muscle Tonus Muscle Skeletal Neural Conduction Neural Inhibition Presynaptic Terminals Pyramidal Tracts Reflex Sacrum Spinal Cord Spinal Nerve Roots Synaptic Transmission
Therapeutic Potential of Astrocyte Transplantation.
Cell transplantation is an attractive treatment strategy for a variety of brain disorders, as it promises to replenish lost functions and rejuvenate the brain. In particular, transplantation of astrocytes has come into light...
A Cre-lox approach for transient transgene expression in neural precursor cells and long-term tracking of their progeny in vitro and in vivo.
Clinical, pathological and functional characterization of riboflavin-responsive neuropathy.
Andreea Manole, Zane Jaunmuktane, Iain Hargreaves, Marthe HR Ludtmann, Vincenzo Salpietro, Oscar D Bello, Simon Pope, Amelie Pandraud, Alejandro Horga, Renata S Scalco, Abi Li, Balasubramaniem Ashokkumar, Charles M Lourenço, Simon Heales, Rita Horvath, Patrick F Chinnery, Camilo Toro, Andrew B Singleton, Thomas S Jacques, Andrey Y Abramov, Francesco Muntoni, Michael G Hanna, Mary M Reilly, Tamas Revesz, Dimitri M Kullmann, James EC Jepson, Henry Houlden
Mar 07, 2019
Brown-Vialetto-Van Laere syndrome represents a phenotypic spectrum of motor, sensory, and cranial nerve neuropathy, often with ataxia, optic atrophy and respiratory problems leading to ventilator-dependence. Loss-of-function...
Brown-Vialetto-Van Laere syndrome SLC52A2 SLC52A3 Riboflavin Adolescent Animals Atrophy Brain Bulbar Palsy Progressive Child Child Preschool Citrate (si)-Synthase Drosophila melanogaster Electron Transport Complex I Electron Transport Complex II Electron Transport Complex III Female FIBROBLASTS Gene Knockdown Techniques Hearing Loss Sensorineural Humans In Vitro Techniques Infant Locomotion longevity Male Membrane Transport Proteins Microscopy Electron Neural Pathways Receptors G-Protein-Coupled Riboflavin Spinal Cord Spinocerebellar Tracts Spinothalamic Tracts Young Adult
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