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Results: 33
Multi-scale ensemble properties of the Escherichia coli RNA degradosome.
Tom Dendooven, Giulia Paris, Alexander V Shkumatov, Md Saiful Islam, Alister Burt, Marta A Kubańska, Tai Yuchen Yang, Steven W Hardwick, Ben F Luisi
Aug 20, 2021
In organisms from all domains of life, multi-enzyme assemblies play central roles in defining transcript lifetimes and facilitating RNA-mediated regulation of gene expression. An assembly dedicated to such roles, known as the...
RNA condensates RNA metabolism RNA surveillance RNase E colloidal polymer Intrinsically Disordered Protein post-transcriptional gene regulation Ribonuclease riboregulation Catalytic Domain Cryoelectron Microscopy Electrophoretic Mobility Shift Assay Endoribonucleases Escherichia coli Escherichia coli Proteins Gene Expression Regulation Bacterial Intrinsically Disordered Proteins Models Structural Multienzyme Complexes Mutation Polyribonucleotide Nucleotidyltransferase RNA Helicases RNA processing Post-Transcriptional RNA Bacterial Ribonucleases Static Electricity Tomography
Insights into Coupled Folding and Binding Mechanisms from Kinetic Studies.
IDP biophysics coupled folding and binding Electrostatics Kinetics phi-value protein dynamic protein electrostatics Protein Folding protein-protein interactions residual structure signaling Apoptosis Regulatory Proteins CREB-Binding Protein Cyclic AMP Response Element-Binding Protein Humans Hydrophobic and Hydrophilic Interactions Intrinsically Disordered Proteins Kinetics Molecular Dynamics Simulation Myeloid Cell Leukemia Sequence 1 Protein Protein Binding Protein Folding Protein Interaction Domains and Motifs Proto-Oncogene Proteins Signal Transduction Static Electricity Thermodynamics
Physicochemical-guided design of cathelicidin-derived peptides generates membrane active variants with therapeutic potential.
Nelson GJ Oliveira, Marlon H Cardoso, Nadya Velikova, Marcel Giesbers, Jerry M Wells, Taia MB Rezende, Renko de Vries, Octávio L Franco
Jul 27, 2020
The spread of multi-drug resistance and the slow pace at which antibiotics come onto the market are undermining our ability to treat human infections, leading to high mortality rates. Aiming to overcome this global crisis...
Unique charge-dependent constraint on collagen recognition by integrin α10β1.
Samir W Hamaia, Daisy Luff, Emma J Hunter, Jean-Daniel Malcor, Dominique Bihan, Donald Gullberg, Richard W Farndale
Oct 31, 2016
C2C12 cells Cartilage GROGER Integrin I domain Triple-helical peptides Amino Acid Motifs Amino Acid Sequence Animals Binding Sites cations Divalent Cell Line Collagen Type II Edetic Acid Gene Expression Humans Integrin alpha Chains Magnesium Mice Models Molecular Muscle Fibers Skeletal Peptides Protein Binding Protein Conformation alpha-Helical Protein Conformation beta-Strand Protein Interaction Domains and Motifs Recombinant Proteins Sequence Alignment Static Electricity
Calicivirus VP2 forms a portal-like assembly following receptor engagement.
Michaela J Conley, Marion McElwee, Liyana Azmi, Mads Gabrielsen, Olwyn Byron, Ian G Goodfellow, David Bhella
Feb 04, 2019
CRIB effector disorder
CRIB effectors Intrinsically Disordered Proteins Protein Conformation small G-proteins Animals GTP Phosphohydrolases GTP-Binding Proteins Gene Expression Regulation Humans Hydrophobic and Hydrophilic Interactions Membrane Proteins Nonlinear dynamics Polylysine Protein Binding Protein Domains Protein Structure Quaternary Signal Transduction Static Electricity Tumor Suppressor Proteins cdc42 GTP-Binding Protein rac1 GTP-Binding Protein
The SARS-CoV-2 viral load in COVID-19 patients is lower on face mask filters than on nasopharyngeal swabs.
Agnieszka Smolinska, David S Jessop, Kirk L Pappan, Alexandra de Saedeleer, Amerjit Kang, Alexandra L Martin, Max Allsworth, Charlotte Tyson, Martine P Bos, Matt Clancy, Mike Morel, Tony Cooke, Tom Dymond, Claire Harris, Jacqui Galloway, Paul Bresser, Nynke Dijkstra, Viresh Jagesar, Paul HM Savelkoul, Erik VH Beuken, Wesley HV Nix, Renaud Louis, Muriel Delvaux, Doriane Calmes, Benoit Ernst, Simona Pollini, Anna Peired, Julien Guiot, Sara Tomassetti, Andries E Budding, Frank McCaughan, Stefan J Marciniak, Marc P van der Schee
Sep 01, 2021
Face masks and personal respirators are used to curb the transmission of SARS-CoV-2 in respiratory droplets; filters embedded in some personal protective equipment could be used as a non-invasive sample source for applications...
Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions.
Georg Krainer, Timothy J Welsh, Jerelle A Joseph, Jorge R Espinosa, Sina Wittmann, Ella de Csilléry, Akshay Sridhar, Zenon Toprakcioglu, Giedre Gudiškytė, Magdalena A Czekalska, William E Arter, Jordina Guillén-Boixet, Titus M Franzmann, Seema Qamar, Peter St George-Hyslop, Anthony A Hyman, Rosana Collepardo-Guevara, Simon Alberti, Tuomas PJ Knowles
Mar 24, 2021
Liquid-liquid phase separation of proteins underpins the formation of membraneless compartments in living cells. Elucidating the molecular driving forces underlying protein phase transitions is therefore a key objective for...
Role of Non-Native Electrostatic Interactions in the Coupled Folding and Binding of PUMA with Mcl-1
Stiffening by Osmotic Swelling Constraint in Cartilage-Like Cell Culture Scaffolds.
Giovanni S Offeddu, Constantin E Tanase, Sotiria Toumpaniari, Michelle L Oyen, Ruth E Cameron
Sep 21, 2018
Liquid-crystalline ordering of antimicrobial peptide-DNA complexes controls TLR9 activation.
Nathan W Schmidt, Fan Jin, Roberto Lande, Tine Curk, Wujing Xian, Calvin Lee, Loredana Frasca, Daan Frenkel, Jure Dobnikar, Michel Gilliet, Gerard CL Wong
Jul 13, 2015
The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation.
Anita Pras, Bert Houben, Francesco A Aprile, Renée Seinstra, Rodrigo Gallardo, Leen Janssen, Wytse Hogewerf, Christian Gallrein, Matthias De Vleeschouwer, Alejandro Mata-Cabana, Mandy Koopman, Esther Stroo, Minke de Vries, Samantha Louise Edwards, Janine Kirstein, Michele Vendruscolo, Salvatore Fabio Falsone, Frederic Rousseau, Joost Schymkowitz, Ellen AA Nollen
Nov 25, 2021
While aggregation-prone proteins are known to accelerate aging and cause age-related diseases, the cellular mechanisms that drive their cytotoxicity remain unresolved. The orthologous proteins MOAG-4, SERF1A, and SERF2 have...
MOAG-4 SERF Amyloid protein aggregation protein quality control Amino Acid Sequence Amyloid Amyloidogenic Proteins Animals Binding Sites Caenorhabditis elegans Caenorhabditis elegans Proteins Gene Expression Regulation HEK293 Cells Humans Hydrophobic and Hydrophilic Interactions Intracellular Signaling Peptides and Proteins Nerve Tissue Proteins Peptides Protein Aggregates Protein Array Analysis Protein Binding Signal Transduction Static Electricity ALPHA-SYNUCLEIN
DNA binds to a specific site of the adhesive blood-protein von Willebrand factor guided by electrostatic interactions.
Angélica Sandoval-Pérez, Ricarda ML Berger, Adiran Garaizar, Stephen E Farr, Maria A Brehm, Gesa König, Stefan W Schneider, Rosana Collepardo-Guevara, Volker Huck, Joachim O Rädler, Camilo Aponte-Santamaría
Aug 19, 2020
Neutrophils release their intracellular content, DNA included, into the bloodstream to form neutrophil extracellular traps (NETs) that confine and kill circulating pathogens. The mechanosensitive adhesive blood protein, von...
Role of the C-terminal domain in the structure and function of tetrameric sodium channels.
Claire Bagnéris, Paul G Decaen, Benjamin A Hall, Claire E Naylor, David E Clapham, Christopher WM Kay, BA Wallace
Feb 13, 2020
Voltage-gated sodium channels have essential roles in electrical signalling. Prokaryotic sodium channels are tetramers consisting of transmembrane (TM) voltage-sensing and pore domains, and a cytoplasmic carboxy-terminal domain....
Alphaproteobacteria Amino Acid Sequence Bacterial Proteins Crystallography X-Ray Electron Spin Resonance Spectroscopy Escherichia coli Ion Channel Gating Molecular Dynamics Simulation Molecular Sequence Data Protein Multimerization Protein Structure Secondary Protein Structure Tertiary Recombinant Proteins Static Electricity Voltage-Gated Sodium Channels
Optimization of Protein-Ligand Electrostatic Interactions Using an Alchemical Free-Energy Method.
We present an explicit solvent alchemical free-energy method for optimizing the partial charges of a ligand to maximize the binding affinity with a receptor. This methodology can be applied to known ligand-protein complexes to...
Amino acid residues in five separate HLA genes can explain most of the known associations between the MHC and primary biliary cholangitis.
Rebecca Darlay, Kristin L Ayers, George F Mells, Lynsey S Hall, Jimmy Z Liu, Mohamed A Almarri, Graeme J Alexander, David E Jones, Richard N Sandford, Carl A Anderson, Heather J Cordell
Feb 11, 2019
Primary Biliary Cholangitis (PBC) is a chronic autoimmune liver disease characterised by progressive destruction of intrahepatic bile ducts. The strongest genetic association is with HLA-DQA1*04:01, but at least three additional...
Amino Acid Sequence Amino Acid Substitution Genes MHC Class II Genetic Association Studies Genetic Predisposition to Disease HLA Antigens HLA-C Antigens HLA-DP beta-Chains HLA-DQ alpha-Chains HLA-DQ beta-Chains HLA-DRB1 Chains Humans Liver Cirrhosis Biliary Major Histocompatibility Complex Models Genetic Models Molecular Polymorphism Single Nucleotide Protein Conformation Regression Analysis Static Electricity
Three-dimensional structural modelling and calculation of electrostatic potentials of HLA Bw4 and Bw6 epitopes to explain the molecular basis for alloantibody binding
Predicting Humoral Alloimmunity from Differences in Donor and Recipient HLA Surface Electrostatic Potential.
Dermot H Mallon, Christiane Kling, Matthew Robb, Eva Ellinghaus, J Andrew Bradley, Craig J Taylor, Dieter Kabelitz, Vasilis Kosmoliaptsis
Dec 05, 2018
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