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p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1.
Mar Quiñones, Omar Al-Massadi, Cintia Folgueira, Stephan Bremser, Rosalía Gallego, Leonardo Torres-Leal, Roberta Haddad-Tóvolli, Cristina García-Caceres, Rene Hernandez-Bautista, Brian YH Lam, Daniel Beiroa, Estrella Sanchez-Rebordelo, Ana Senra, Jose A Malagon, Patricia Valerio, Marcos F Fondevila, Johan Fernø, Maria M Malagon, Raian Contreras, Paul Pfluger, Jens C Brüning, Giles Yeo, Matthias Tschöp, Carlos Diéguez, Miguel López, Marc Claret, Peter Kloppenburg, Guadalupe Sabio, Ruben Nogueiras
Sep 10, 2018
p53 is a well-known tumor suppressor that has emerged as an important player in energy balance. However, its metabolic role in the hypothalamus remains unknown. Herein, we show that mice lacking p53 in agouti-related peptide...