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Citrullination is a post-translational modification of higher organisms that deiminates arginines in proteins and peptides. It occurs in physiological processes but also pathologies such as multiple sclerosis, fibrosis...

Bacterial Proteins Catalytic Domain Citrulline Crystallography X-Ray Hydrolases Models Molecular Porphyromonas gingivalis Protein Binding Protein Processing Post-Translational Protein Structure Secondary Protein-Arginine Deiminases Structural Homology Protein Virulence Factors

IFN-stimulated gene S-adenosyl methionine antiviral cellular factor free radical radical SAM Animals Mice Protein Domains Protein Folding Proteins Structural Homology Protein Structure-Activity Relationship

BACKGROUND: Growth/differentiation factor 8 (GDF8) and GDF11 are two highly similar members of the transforming growth factor β (TGFβ) family. While GDF8 has been recognized as a negative regulator of muscle growth and...

Ligands myostatin Receptor structure Transforming growth factor β (TGFβ) Amino Acid Sequence Animals Bone Morphogenetic Proteins Cells Cultured Crystallography X-Ray Follistatin Genes Reporter Growth Differentiation Factors Humans Injections Intravenous Ligands Luciferases Mice Models Molecular Myoblasts Myocardium myostatin Phosphorylation Protein Binding Protein Serine-Threonine Kinases Receptor Transforming Growth Factor-beta Type I Receptors Transforming Growth Factor beta Sequence Alignment Signal Transduction Smad Proteins Structural Homology Protein Structure-Activity Relationship

The conserved SecYEG protein-conducting channel and the accessory proteins SecDF-YajC and YidC constitute the bacterial holo-translocon (HTL), capable of protein-secretion and membrane-protein insertion. By employing an...

Binding Sites Cloning Molecular Cryoelectron Microscopy Escherichia coli Escherichia coli Proteins Gene Expression Genetic Vectors Membrane Transport Proteins Methanocaldococcus Models Molecular neutron diffraction Protein Binding Protein Conformation alpha-Helical Protein Conformation beta-Strand Protein Interaction Domains and Motifs Protein Transport Recombinant Proteins SEC Translocation Channels SCATTERING Small Angle Structural Homology Protein Substrate Specificity Thermus thermophilus

Macromolecular structures can be solved by molecular replacement provided that suitable search models are available. Models from distant homologues may deviate too much from the target structure to succeed, notwithstanding an...

ARCIMBOLDO_SHREDDER fragment-based molecular replacement Molecular replacement phasing small fragments Algorithms Bacterial Proteins Computer Simulation Crystallography X-Ray Macromolecular Substances Models Molecular Structural Homology Protein

Biophysical Phenomena Carrier Proteins Cell Cycle Proteins Cross-Linking Reagents Crystallography X-Ray DNA-Binding Proteins Humans Intracellular Signaling Peptides and Proteins Mass Spectrometry Models Molecular Nuclear Proteins Protein Binding Protein Domains Protein Multimerization Structural Homology Protein

Complex I (NADH:ubiquinone oxidoreductase) in mammalian mitochondria is an L-shaped assembly of 44 protein subunits with one arm buried in the inner membrane of the mitochondrion and the orthogonal arm protruding about 100 Å...

Arginine Modification Bioenergetics/Electron Transfer Complex Complex I Electron Transport System (ETS) Mitochondria Protein Chemical Modification protein hydroxylation Protein Methylation Animals Bacterial Proteins Binding Sites Cattle Electron Transport Complex I Flavin Mononucleotide Fungal Proteins HEK293 Cells Humans Lipid Bilayers Mitochondria Heart NAD Paracoccus denitrificans Pichia Structural Homology Protein Thermus thermophilus Ubiquinone

Phasing by molecular replacement remains difficult for targets that are far from the search model or in situations where the crystal diffracts only weakly or to low resolution. Here, the process of determining and refining the...

Amidohydrolases Amino Acid Sequence Automation Laboratory Corynebacterium glutamicum Crystallography X-Ray Models Molecular Molecular Sequence Data Sequence Alignment Software Structural Homology Protein

Bacterial Proteins Binding Sites Cloning Molecular Computational Biology Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System Escherichia coli Gene Expression Ligands Models Molecular Mycobacterium tuberculosis Peptide Fragments Phylogeny Protein Binding Recombinant Proteins Structural Homology Protein

Biophysical Phenomena Crystallography X-Ray Dimerization Macromolecular Substances Models Molecular pattern recognition Automated Protein Binding Protein Structure Tertiary Proteins Structural Homology Protein Thermodynamics

Intermolecular contacts between integrin LFA-1 (α(L)β(2)) and ICAM-1 derive solely from the integrin α(L) I domain and the first domain (D1) of ICAM-1. This study presents a crystal structure of the engineered complex of the...

Allosteric Regulation Amino Acid Sequence Amino Acid Substitution Crystallography X-Ray Directed Molecular Evolution Humans Hydrogen Bonding Intercellular Adhesion Molecule-1 Lymphocyte Function-Associated Antigen-1 Models Molecular Molecular Sequence Data Mutagenesis Site-Directed Protein Binding Protein Interaction Domains and Motifs Protein Structure Secondary Structural Homology Protein

Disease Humans Membrane Proteins Mutation Missense Point Mutation Protein Stability Software Structural Homology Protein

Acetyl Coenzyme A Amino Acid Sequence Apoenzymes Bacterial Proteins Binding Sites Catalytic Domain Computational Biology Conserved Sequence Crystallography X-Ray Expert Systems Glyoxylates Indoles Ligands Magnesium Malate Synthase Models Molecular Molecular Docking Simulation Molecular Structure Protein Conformation Protein Structure Secondary Pseudomonas aeruginosa Recombinant Proteins Sequence Alignment Structural Homology Protein