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Results: 36
Pathogenic NFKB2 variant in the ankyrin repeat domain (R635X) causes a variable antibody deficiency.
Paul Tuijnenburg, Hana Lango Allen, Godelieve J de Bree, Sinisa Savic, Machiel H Jansen, Claire Stockdale, Ilenia Simeoni, Ineke JM Ten Berge, Ester MM van Leeuwen, NIHR BioResource, James E Thaventhiran, Taco W Kuijpers
Apr 16, 2019
Genetic studies are identifying an increasing number of monogenic causes of Common Variable Immunodeficiency (CVID). Pathogenic variants in the C-terminus of NFKB2 have been identified in the subset of CVID patients whose...
B cells Common Variable Immunodeficiency NFKB2 T cells Adrenal Insufficiency Ankyrin Repeat B-Lymphocytes Cells Cultured Common Variable Immunodeficiency Ectodermal Dysplasia Female Humans Immunoglobulin Class Switching Immunologic Memory Immunophenotyping Lymphocyte Activation Male Mutation NF-kappa B p52 Subunit Pedigree Receptors CXCR5 T-Lymphocytes
The MS Remyelinating Drug Bexarotene (an RXR Agonist) Promotes Induction of Human Tregs and Suppresses Th17 Differentiation <i>In Vitro</i>.
Christopher M Gaunt, Daniel B Rainbow, Ruairi J Mackenzie, Lorna B Jarvis, Hani S Mousa, Nicholas Cunniffe, Zoya Georgieva, J William Brown, Alasdair J Coles, Joanne L Jones
Sep 27, 2021
Published by: Frontiers in immunology
Alemtuzumab for refractory primary systemic vasculitis-a randomised controlled dose ranging clinical trial of efficacy and safety (ALEVIATE).
Seerapani Gopaluni, Rona Smith, Donna Goymer, Hugh Cahill, Elizabeth Broadhurst, Elizabeth Wallin, Mark McClure, Afzal Chaudhry, David Jayne
Apr 01, 2022
BACKGROUND: Primary systemic vasculitis (PSV) is a heterogeneous group of autoimmune conditions. There is an unmet need for alternative therapies that lead to sustained remission in patients with refractory disease. Alemtuzumab...
EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling.
Lyra O Randzavola, Paige M Mortimer, Emma Garside, Elizabeth R Dufficy, Andrea Schejtman, Georgia Roumelioti, Lu Yu, Mercedes Pardo, Kerstin Spirohn, Charlotte Tolley, Cordelia Brandt, Katherine Harcourt, Esme Nichols, Mike Nahorski, Geoff Woods, James C Williamson, Shreehari Suresh, John M Sowerby, Misaki Matsumoto, Celio Xc Santos, Cher Shen Kiar, Subhankar Mukhopadhyay, William M Rae, Gordon J Dougan, John Grainger, Paul J Lehner, Michael A Calderwood, Jyoti Choudhary, Simon Clare, Anneliese Speak, Giorgia Santilli, Alex Bateman, Kenneth GC Smith, Francesca Magnani, David C Thomas
Dec 20, 2022
Targeting mitochondrial oxidative stress with MitoQ reduces NET formation and kidney disease in lupus-prone MRL- lpr mice
The MS Remyelinating Drug Bexarotene (an RXR Agonist) Promotes Induction of Human Tregs and Suppresses Th17 Differentiation In Vitro.
Christopher M Gaunt, Daniel B Rainbow, Ruairi J Mackenzie, Lorna B Jarvis, Hani S Mousa, Nicholas Cunniffe, Zoya Georgieva, J William Brown, Alasdair J Coles, Joanne L Jones
Jul 19, 2021
T cells Th17 & Tregs cells Autoimmunity Multiple Sclerosis retinoid X receptor (RXR) retinoids Adult Alitretinoin Bexarotene CD4-Positive T-Lymphocytes Cells Cultured Clinical Trials as Topic Fatty Acids Unsaturated Female Forkhead Transcription Factors Humans Leukocytes Mononuclear lymphopoiesis Middle Aged remyelination Retinoid X Receptors T-Lymphocytes Regulatory Tetrahydronaphthalenes Th17 Cells
Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity.
Lyra O Randzavola, Katharina Strege, Marie Juzans, Yukako Asano, Jane C Stinchcombe, Christian M Gawden-Bone, Matthew NJ Seaman, Taco W Kuijpers, Gillian M Griffiths
Dec 12, 2019
CD8 cytotoxic T lymphocytes (CTLs) rely on rapid reorganization of the branched F-actin network to drive the polarized secretion of lytic granules, initiating target cell death during the adaptive immune response. Branched...
Non-Functionalized Ultrasmall Silica Nanoparticles Directly and Size-Selectively Activate T Cells.
Bradley Vis, Rachel E Hewitt, Nuno Faria, Carlos Bastos, Helen Chappell, Laetitia Pele, Ravin Jugdaohsingh, Stephen D Kinrade, Jonathan J Powell
Dec 06, 2018
Quantifying persistence in the T‐cell signaling network using an optically controllable antigen receptor
Abstract: T cells discriminate between healthy and infected cells with remarkable sensitivity when mounting an immune response, which is hypothesized to depend on T cells combining stimuli from multiple antigen‐presenting cell...
EMBO41 EMBO19 EMBO37 article ARTICLES Cell Signaling optogenetics Receptors T cells Transcription Factors
Published by: Molecular Systems Biology
Autophosphorylation and the Dynamics of the Activation of Lck
Abstract: Lck (lymphocyte-specific protein tyrosine kinase) is an enzyme which plays a number of important roles in the function of immune cells. It belongs to the Src family of kinases which are known to undergo...
Whole blood-based measurement of SARS-CoV-2-specific T cells reveals asymptomatic infection and vaccine immunogenicity in healthy subjects and patients with solid-organ cancers.
Martin J Scurr, Wioleta M Zelek, George Lippiatt, Michelle Somerville, Stephanie EA Burnell, Lorenzo Capitani, Kate Davies, Helen Lawton, Thomas Tozer, Tara Rees, Kerry Roberts, Mererid Evans, Amanda Jackson, Charlotte Young, Lucy Fairclough, Paddy Tighe, Mark Wills, Andrew D Westwell, B Paul Morgan, Awen Gallimore, Andrew Godkin
Dec 24, 2021
Accurate assessment of SARS-CoV-2 immunity is critical in evaluating vaccine efficacy and devising public health policies. Whilst the exact nature of effective immunity remains incompletely defined, SARS-CoV-2-specific T-cell...
Targeting mitochondrial oxidative stress with MitoQ reduces NET formation and kidney disease in lupus-prone MRL-lpr mice.
Karen A Fortner, Luz P Blanco, Iwona Buskiewicz, Nick Huang, Pamela C Gibson, Deborah L Cook, Hege L Pedersen, Peter ST Yuen, Michael P Murphy, Andras Perl, Mariana J Kaplan, Ralph C Budd
Jun 05, 2020
OBJECTIVES: Recent investigations in humans and mouse models with lupus have revealed evidence of mitochondrial dysfunction and production of mitochondrial reactive oxygen species (mROS) in T cells and neutrophils. This can...
T cells Autoimmune Diseases Inflammation Systemic Lupus Erythematosus Animals Autoantibodies Disease Models Animal Extracellular Traps Female Humans Interferon Type I Kidney Kidney Diseases Lupus Erythematosus Systemic Male Mice Mice Inbred MRL lpr Mitochondria Neutrophils Organophosphorus Compounds Oxidation-Reduction Oxidative Stress Reactive Oxygen Species T-Lymphocytes Ubiquinone
The MS Remyelinating Drug Bexarotene (an RXR Agonist) Promotes Induction of Human Tregs and Suppresses Th17 Differentiation In Vitro
Christopher M. Gaunt, Daniel B. Rainbow, Ruairi J. Mackenzie, Lorna B. Jarvis, Hani S. Mousa, Nicholas Cunniffe, Zoya Georgieva, J. William Brown, Alasdair J. Coles, Joanne L. Jones
Aug 26, 2021
The retinoid X receptor agonist bexarotene promotes remyelination in patients with multiple sclerosis. Murine studies have also demonstrated that RXR agonists have anti-inflammatory effects by enhancing the ability of...
The DILfrequency study is an adaptive trial to identify optimal IL-2 dosing in patients with type 1 diabetes.
Eleonora Seelig, James Howlett, Linsey Porter, Lucy Truman, James Heywood, Jane Kennet, Emma L Arbon, Katerina Anselmiova, Neil M Walker, Ravinder Atkar, Marcin L Pekalski, Ed Rytina, Mark Evans, Linda S Wicker, John A Todd, Adrian P Mander, Simon Bond, Frank Waldron-Lynch
Nov 21, 2018
Autoimmune Diseases Autoimmunity Clinical Trials Diabetes T cells Adolescent Adult Aged Diabetes mellitus Type 1 Dose-Response Relationship Drug Drug Administration Schedule Feasibility Studies Female Humans Interleukin-2 Interleukin-2 Receptor alpha Subunit Lymphocyte Activation Lymphocyte Count Male Middle Aged Recombinant Proteins T-Lymphocytes Regulatory Treatment Outcome Young Adult
Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2
John A Todd, Marina Evangelou, Antony J Cutler, Marcin L Pekalski, Neil M Walker, Helen E Stevens, Linsey Porter, Deborah J Smyth, Daniel B Rainbow, Ricardo C Ferreira, Laura Esposito, Kara MD Hunter, Kevin Loudon, Kathryn Irons, Jennie H Yang, Charles JM Bell, Helen Schuilenburg, James Heywood, Ben Challis, Sankalpa Neupane, Pamela Clarke, Gillian Coleman, Sarah Dawson, Donna Goymer, Katerina Anselmiova, Jane Kennet, Judy Brown, Sarah Caddy, Jia Lu, Jane Greatorex, Ian Gordon Goodfellow, Chris Wallace, Tim I Tree, Mark Evans, Adrian Paul Mander, Simon Bond, Linda S Wicker, Frank Waldron-Lynch
Aug 16, 2017
Published by: PLoS Medicine
Autophosphorylation and the Dynamics of the Activation of Lck
Abstract: Lck (lymphocyte-specific protein tyrosine kinase) is an enzyme which plays a number of important roles in the function of immune cells. It belongs to the Src family of kinases which are known to undergo...
Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy.
David Gyori, Ee Lyn Lim, Francis M Grant, Dominik Spensberger, Rahul Roychoudhuri, Stephen J Shuttleworth, Klaus Okkenhaug, Len R Stephens, Phillip T Hawkins
Aug 20, 2018
cancer immunotherapy immunology MACROPHAGES oncology T cells Aminopyridines Animals Cell Line Tumor Class I Phosphatidylinositol 3-Kinases Diphtheria Toxin Disease Models Animal Drug Resistance Neoplasm Female Forkhead Transcription Factors Gene Knockout Techniques Humans Lymphocyte Depletion MACROPHAGES Male Mice Mice Transgenic Neoplasms Phosphatidylinositol 3-Kinases Phosphoinositide-3 Kinase Inhibitors Primary Cell Culture Purines Pyrroles Quinazolinones Receptors Granulocyte-Macrophage Colony-Stimulating Factor T-Lymphocytes Regulatory Tumor Microenvironment
Carcinomas assemble a filamentous CXCL12-keratin-19 coating that suppresses T cell-mediated immune attack.
Zhikai Wang, Philip Moresco, Ran Yan, Jiayun Li, Ya Gao, Daniele Biasci, Min Yao, Jordan Pearson, Jaclyn F Hechtman, Tobias Janowitz, Raza M Zaidi, Matthew J Weiss, Douglas T Fearon
Feb 20, 2022
Cancer immunotherapy frequently fails because most carcinomas have few T cells, suggesting that cancers can suppress T cell infiltration. Here, we show that cancer cells of human pancreatic ductal adenocarcinoma (PDA)...
Reduction of T-Helper Cell Responses to Recall Antigen Mediated by Codelivery with Peptidoglycan via the Intestinal Nanomineral-Antigen Pathway.
Naturally occurring intestinal nanomineral particles constituently form in the mammalian gut and trap luminal protein and microbial components. These cargo loaded nanominerals are actively scavenged by M cells of intestinal...
Abnormalities of age-related T cell senescence in Parkinson's disease.
immune markers immunosenescence Parkinson’s disease T cells Aged aging Antigens CD Case-Control Studies Cellular Senescence Cytomegalovirus Female Flow Cytometry Humans Immunoglobulin G Immunophenotyping immunosenescence Leukocytes Mononuclear Male Middle Aged Parkinson Disease serology T-Lymphocytes
Maternal allo-recognition of the fetus
Immunological adjustments are needed to accommodate the close contact between two genetically different individuals, the mother and her baby, during mammalian pregnancy. Contact occurs between fetal somatic or placental cells...
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