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Vitamin A, systemic T-cells, and the eye
The first discovered vitamin, vitamin A, exists in a range of forms, primarily retinoids and provitamin carotenoids. The bioactive forms of vitamin A, retinol and retinoic acid, have many critical functions in body systems...
Activated Cdc42-associated kinase 1 (ACK1) binds the sterile α motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines
T cell Cell Signaling cluster of differentiation 4 (CD4) immunology non-receptor tyrosine kinase (nRTK) protein phosphorylation sterile α motif (SAM) Adaptor Proteins Signal Transducing Amino Acid Motifs Amino Acid Substitution Animals Humans Jurkat Cells Lymphocyte Activation Mice Mutation Missense Phosphoproteins Phosphorylation Protein Domains Protein-Tyrosine Kinases Receptors Antigen T-Cell T-Lymphocytes Tyrosine
Non-Invasive Multiphoton Imaging of Islets Transplanted Into the Pinna of the NOD Mouse Ear Reveals the Immediate Effect of Anti-CD3 Treatment in Autoimmune Diabetes.
Robert A Benson, Fabien Garcon, Asha Recino, John R Ferdinand, Menna R Clatworthy, Herman Waldmann, James M Brewer, Klaus Okkenhaug, Anne Cooke, Paul Garside, Maja Wållberg
Sep 05, 2018
T cell anti-CD3 Autoimmunity Imaging Immunotherapy islets multiphoton type 1 diabetes Animals Autoimmunity Diabetes mellitus Type 1 Disease Models Animal Ear Auricle Islets of Langerhans Islets of Langerhans Transplantation Mice Mice Inbred C57BL Mice Inbred NOD Mice SCID Mice Transgenic Microscopy Fluorescence Multiphoton Muromonab-CD3 T-Lymphocytes Transplantation Isogeneic
Comparative Cell Surface Proteomic Analysis of the Primary Human T Cell and Monocyte Responses to Type I Interferon.
Lior Soday, Martin Potts, Leah M Hunter, Benjamin J Ravenhill, Jack W Houghton, James C Williamson, Robin Antrobus, Mark R Wills, Nicholas J Matheson, Michael P Weekes
Feb 24, 2021
The cellular response to interferon (IFN) is essential for antiviral immunity, IFN-based therapy and IFN-related disease. The plasma membrane (PM) provides a critical interface between the cell and its environment, and is the...
Vitamin A, systemic T-cells, and the eye
The first discovered vitamin, vitamin A, exists in a range of forms, primarily retinoids and provitamin carotenoids. The bioactive forms of vitamin A, retinol and retinoic acid, have many critical functions in body systems...
IL-10-Mediated Refueling of Exhausted T Cell Mitochondria Boosts Anti-Tumour Immunity.
Immunotherapy has underscored a revolution in cancer treatment. Yet, many patients fail to respond due to T cell exhaustion. Here, an intervention that restores mitochondrial function reversed the exhausted T cell phenotype to...
Virus replication begins in dendritic cells during the transmission of HIV-1 from mature dendritic cells to T cells
Background: To initiate immunity, dendritic cells (DCs) capture antigens or viruses at body surfaces, undergo maturation to express T-cell costimulatory molecules, and then migrate to lymphoid organs. DCs at body surfaces can...
Published by: Rockefeller University
EWI-2 Inhibits Cell-Cell Fusion at the HIV-1 Virological Presynapse.
Emily E Whitaker, Nicholas J Matheson, Sarah Perlee, Phillip B Munson, Menelaos Symeonides, Markus Thali
Dec 09, 2019
Cell-to-cell transfer of virus particles at the Env-dependent virological synapse (VS) is a highly efficient mode of HIV-1 transmission. While cell-cell fusion could be triggered at the VS, leading to the formation of syncytia...
Infection with the sheep gastrointestinal nematode Teladorsagia circumcincta increases luminal pathobionts
Alba Cortés, John Wills, Xiaopei Su, Rachel E. Hewitt, Jack Robertson, Riccardo Scotti, Daniel R. G. Price, Yvonne Bartley, Tom N. McNeilly, Lutz Krause, Jonathan J. Powell, Alasdair J. Nisbet, Cinzia Cantacessi
Jun 06, 2020
Abstract: Background: The multifaceted interactions between gastrointestinal (GI) helminth parasites, host gut microbiota and immune system are emerging as a key area of research within the field of host-parasite relationships....
Infection with the sheep gastrointestinal nematode Teladorsagia circumcincta increases luminal pathobionts
Alba Cortés, John Wills, Xiaopei Su, Rachel E. Hewitt, Jack Robertson, Riccardo Scotti, Daniel R. G. Price, Yvonne Bartley, Tom N. McNeilly, Lutz Krause, Jonathan J. Powell, Alasdair J. Nisbet, Cinzia Cantacessi
Apr 30, 2021
Abstract: Background: The multifaceted interactions between gastrointestinal (GI) helminth parasites, host gut microbiota and immune system are emerging as a key area of research within the field of host-parasite relationships....
Comparative Cell Surface Proteomic Analysis of the Primary Human T Cell and Monocyte Responses to Type I Interferon
Lior Soday, Martin Potts, Leah M. Hunter, Benjamin J. Ravenhill, Jack W. Houghton, James C. Williamson, Robin Antrobus, Mark R. Wills, Nicholas J. Matheson, Michael P. Weekes
Feb 22, 2021
The cellular response to interferon (IFN) is essential for antiviral immunity, IFN-based therapy and IFN-related disease. The plasma membrane (PM) provides a critical interface between the cell and its environment, and is the...
Phosphoinositide 3-kinase δ is a regulatory T-cell target in cancer immunotherapy.
Tumour infiltration by regulatory T (Treg) cells contributes to suppression of the anti-tumour immune response, which limits the efficacy of immune-mediated cancer therapies. The phosphoinositide 3-kinase (PI3K) pathway has key...
T cell Regulatory T cell Signal Transduction tumour immunology Animals Antineoplastic Agents Class Ib Phosphatidylinositol 3-Kinase Humans Immunotherapy Lymphocytes Tumor-Infiltrating Molecular Targeted Therapy Neoplasms Phenotype Protein Kinase Inhibitors Signal Transduction T-Lymphocytes Regulatory Tumor Escape Tumor Microenvironment
Does the PI3K pathway promote or antagonize regulatory T cell development and function?
Regulatory T cells (Tregs) prevent autoimmunity and inflammation by suppressing the activation of other T cells and antigen presenting cells. The role of phosphoinositide 3-kinase (PI3K) signaling in Treg is controversial. Some...
Serine Is an Essential Metabolite for Effector T Cell Expansion.
Eric H Ma, Glenn Bantug, Takla Griss, Stephanie Condotta, Radia M Johnson, Bozena Samborska, Nello Mainolfi, Vipin Suri, Hannah Guak, Maria L Balmer, Mark J Verway, Thomas C Raissi, Harmony Tsui, Giselle Boukhaled, Sofia Henriques da Costa, Christian Frezza, Connie M Krawczyk, Adam Friedman, Mark Manfredi, Martin J Richer, Christoph Hess, Russell G Jones
Jan 12, 2018
During immune challenge, T lymphocytes engage pathways of anabolic metabolism to support clonal expansion and the development of effector functions. Here we report a critical role for the non-essential amino acid serine in...
Phgdh Shmt T cell Glycolysis immunometabolism Immunotherapy Metabolic reprogramming metabolism Serine serine biosynthesis Animals Carbon Cell Cycle Checkpoints Cell Proliferation Diet Energy Metabolism Extracellular Space Glycine Listeria monocytogenes Metabolic Networks and Pathways Metabolome Mice Inbred C57BL Purine Nucleotides Serine T-Lymphocytes
Downregulation of HLA-I by the molluscum contagiosum virus mc080 impacts NK-cell recognition and promotes CD8+ T-cell evasion.
Hana Elasifer, Eddie CY Wang, Virginie Prod'homme, James Davies, Simone Forbes, Richard J Stanton, Mihil Patel, Ceri A Fielding, Dawn Roberts, James A Traherne, Nicole Gruber, Joachim J Bugert, Rebecca J Aicheler, Gavin WG Wilkinson
Jun 17, 2020
Molluscum contagiosum virus (MCV) is a common cause of benign skin lesions in young children and currently the only endemic human poxvirus. Following the infection of primary keratinocytes in the epidermis, MCV induces the...
MHC-I Molluscum contagiosum NK cell T cell Antigen Presentation CD8-Positive T-Lymphocytes Cell Line Down-Regulation Endoplasmic Reticulum Histocompatibility Antigens Class I Host-Pathogen Interactions Humans Immune Evasion Keratinocytes Killer Cells Natural molluscum contagiosum virus T-Lymphocytes Cytotoxic Viral Proteins
Evidence of previous SARS-CoV-2 infection in seronegative patients with long COVID.
Benjamin A Krishna, Eleanor Y Lim, Lenette Mactavous, NIHR BioResource Team, Paul A Lyons, Rainer Doffinger, John R Bradley, Kenneth GC Smith, John Sinclair, Nicholas J Matheson, Paul J Lehner, Mark R Wills, Nyaradzai Sithole
Aug 01, 2022
BACKGROUND: There is currently no consensus on the diagnosis, definition, symptoms, or duration of COVID-19 illness. The diagnostic complexity of Long COVID is compounded in many patients who were or might have been infected...
Dendritic Cells Initiate Immune Control of Epstein-Barr Virus Transformation of B Lymphocytes in Vitro
The initiation of cell-mediated immunity to Epstein-Barr virus (EBV) has been analyzed with cells from EBV-seronegative blood donors in culture. The addition of dendritic cells (DCs) is essential to prime naive T cells that...
Published by: Rockefeller University
Membrane-Proximal Epitope Facilitates Efficient T Cell Synapse Formation by Anti-FcRH5/CD3 and Is a Requirement for Myeloma Cell Killing
J Li, NJ Stagg, J Johnston, MJ Harris, SA Menzies, D DiCara, V Clark, M Hristopoulos, R Cook, D Slaga, R Nakamura, L McCarty, S Sukumaran, E Luis, Z Ye, TD Wu, T Sumiyoshi, D Danilenko, GY Lee, K Totpal, D Ellerman, I Hötzel, JR James, TT Junttila
Mar 02, 2017
Infection with the sheep gastrointestinal nematode Teladorsagia circumcincta increases luminal pathobionts.
Alba Cortés, John Wills, Xiaopei Su, Rachel E Hewitt, Jack Robertson, Riccardo Scotti, Daniel RG Price, Yvonne Bartley, Tom N McNeilly, Lutz Krause, Jonathan J Powell, Alasdair J Nisbet, Cinzia Cantacessi
Feb 25, 2020
BACKGROUND: The multifaceted interactions between gastrointestinal (GI) helminth parasites, host gut microbiota and immune system are emerging as a key area of research within the field of host-parasite relationships. In spite...
Automated in situ cell counting Bacterial 16S rRNA gene sequencing Gastrointestinal helminth Gut microbiota Parasite gastroenteritis Pathobiont T cell Teladorsagia circumcincta vaccine Animals Bacteria Feces Gastrointestinal Microbiome Intestinal Diseases Parasitic Nematode Infections Sheep Trichostrongyloidea