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A RAC-GEF network critical for early intestinal tumourigenesis.
KA Pickering, K Gilroy, JW Cassidy, SK Fey, AK Najumudeen, LB Zeiger, DF Vincent, DM Gay, J Johansson, RP Fordham, B Miller, W Clark, A Hedley, EB Unal, C Kiel, E McGhee, LM Machesky, C Nixon, AE Johnsson, M Bain, D Strathdee, SR van Hoof, JP Medema, KI Anderson, SM Brachmann, VM Stucke, A Malliri, M Drysdale, M Turner, L Serrano, K Myant, AD Campbell, OJ Sansom
Feb 08, 2021
RAC1 activity is critical for intestinal homeostasis, and is required for hyperproliferation driven by loss of the tumour suppressor gene Apc in the murine intestine. To avoid the impact of direct targeting upon homeostasis, we...
Intestines Animals Mice Knockout rac1 GTP-Binding Protein Guanine Nucleotide Exchange Factors Adenomatous Polyposis Coli Protein Signal Transduction Organ Specificity Up-Regulation Homeostasis Phenotype Mutation Proto-Oncogene Proteins p21(ras) Proto-Oncogene Proteins c-vav Wnt Signaling Pathway Carcinogenesis T-Lymphoma Invasion and Metastasis-inducing Protein 1