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Abstract: Introduction: Relative oxidation of different metabolic substrates in the heart varies both physiologically and pathologically, in order to meet metabolic demands under different circumstances. 13C labelled substrates...

Original Article Krebs Cycle TCA cycle Isotopomer Analysis Fluxomics Metabolic Substrate Switching Lc–ms/ms Heart

Mycobacterium tuberculosis TCA cycle Allosteric Regulation Fumarate Hydratase selective inhibition Allosteric Regulation Crystallography X-Ray Fluorescence Fumarate Hydratase Mycobacterium tuberculosis

Hypoxia-inducible transcription factors (HIFs) facilitate cellular adaptations to low-oxygen environments. However, it is increasingly recognised that HIFs may be activated in response to metabolic stimuli, even when oxygen is...

2-HG 2-OG dependent dioxygenase 2-Hydroxyglutarate HIF PHD TCA cycle hypoxia inducible factors iron metabolism prolyl hydroxylase

High-dose of vitamin C (L-ascorbic acid, ascorbate) exhibits anti-tumoral effects, primarily mediated by pro-oxidant mechanisms. This cytotoxic effect is thought to affect the reciprocal crosstalk between redox balance and cell...

PTC cells ROS TCA cycle anticancer effects antioxidants cell metabolism Glycolysis vitamin C

The Tricarboxylic Acid (TCA) Cycle is arguably the most critical metabolic cycle in physiology and exists as an essential interface coordinating cellular metabolism, bioenergetics, and redox homeostasis. Despite decades of...

RESEARCH ARTICLE Biochemistry and Chemical Biology Cell Biology TCA cycle Mitochondria metabolism Metabolomics MOUSE

The Tricarboxylic Acid (TCA) Cycle is arguably the most critical metabolic cycle in physiology and exists as an essential interface coordinating cellular metabolism, bioenergetics, and redox homeostasis. Despite decades of...

TCA cycle Biochemistry Cell Biology chemical biology metabolism Metabolomics Mitochondria MOUSE Activating Transcription Factor 4 Amino Acids Animals Cells Cultured Citric Acid Cycle Fumarate Hydratase Kidney Metabolome Mice Oxidation-Reduction RNA Interference Succinate Dehydrogenase

Fluxomics Heart Isotopomer Analysis Krebs Cycle Lc–ms/ms Metabolic Substrate Switching TCA cycle Acetyl Coenzyme A Animals Carbon Isotopes Citric Acid Cycle Glucose Heart Male Mass Spectrometry Mitochondria Models Biological Myocardium Oxidation-Reduction Rats Rats Wistar

High-dose of vitamin C (L-ascorbic acid, ascorbate) exhibits anti-tumoral effects, primarily mediated by pro-oxidant mechanisms. This cytotoxic effect is thought to affect the reciprocal crosstalk between redox balance and cell...

vitamin C PTC cells ROS cell metabolism TCA cycle antioxidants Glycolysis anticancer effects

Renal cell carcinomas (RCCs) are common cancers diagnosed in more than 350,000 people each year worldwide. Several pathways are de-regulated in RCCs, including mTORC1. However, how mTOR drives tumorigenesis in this context is...

TCA cycle cancer metabolism cancer signaling epithelial transformation Fumarate Hydratase Metabolic reprogramming papillary carcinoma rapamycin renal cancer renal cysts Animals Carcinoma Renal Cell Cells Cultured Female Fumarate Hydratase Fumarates Humans Kidney Neoplasms Male Mechanistic Target of Rapamycin Complex 1 Mice Mice Inbred C57BL Tuberous Sclerosis Complex 1 Protein Up-Regulation

INTRODUCTION:Relative oxidation of different metabolic substrates in the heart varies both physiologically and pathologically, in order to meet metabolic demands under different circumstances. 13C labelled substrates have become...

Heart TCA cycle Krebs Cycle Lc–ms/ms Fluxomics Isotopomer Analysis Metabolic Substrate Switching

OXPHOS TCA cycle acute myeloid leukemia antioxidant bone marrow mesenchymal stem cells Chemotherapy Glutathione hematopoietic stem cell niche metabolic adaptation microenvironment Animals Antineoplastic Agents antioxidants Bone Marrow Cells Cultured Energy Metabolism Female Humans Leukemia Myeloid Acute Male Mesenchymal Stem Cells Mice Mice Inbred C57BL Middle Aged