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Results: 323
Insights into Land Plant Evolution Garnered from the Marchantia polymorpha Genome.
John L Bowman, Takayuki Kohchi, Katsuyuki T Yamato, Jerry Jenkins, Shengqiang Shu, Kimitsune Ishizaki, Shohei Yamaoka, Ryuichi Nishihama, Yasukazu Nakamura, Frédéric Berger, Catherine Adam, Shiori Sugamata Aki, Felix Althoff, Takashi Araki, Mario A Arteaga-Vazquez, Sureshkumar Balasubrmanian, Kerrie Barry, Diane Bauer, Christian R Boehm, Liam Briginshaw, Juan Caballero-Perez, Bruno Catarino, Feng Chen, Shota Chiyoda, Mansi Chovatia, Kevin M Davies, Mihails Delmans, Taku Demura, Tom Dierschke, Liam Dolan, Ana E Dorantes-Acosta, D Magnus Eklund, Stevie N Florent, Eduardo Flores-Sandoval, Asao Fujiyama, Hideya Fukuzawa, Bence Galik, Daniel Grimanelli, Jane Grimwood, Ueli Grossniklaus, Takahiro Hamada, Jim Haseloff, Alexander J Hetherington, Asuka Higo, Yuki Hirakawa, Hope N Hundley, Yoko Ikeda, Keisuke Inoue, Shin-Ichiro Inoue, Sakiko Ishida, Qidong Jia, Mitsuru Kakita, Takehiko Kanazawa, Yosuke Kawai, Tomokazu Kawashima, Megan Kennedy, Keita Kinose, Toshinori Kinoshita, Yuji Kohara, Eri Koide, Kenji Komatsu, Sarah Kopischke, Minoru Kubo, Junko Kyozuka, Ulf Lagercrantz, Shih-Shun Lin, Erika Lindquist, Anna M Lipzen, Chia-Wei Lu, Efraín De Luna, Robert A Martienssen, Naoki Minamino, Masaharu Mizutani, Miya Mizutani, Nobuyoshi Mochizuki, Isabel Monte, Rebecca Mosher, Hideki Nagasaki, Hirofumi Nakagami, Satoshi Naramoto, Kazuhiko Nishitani, Misato Ohtani, Takashi Okamoto, Masaki Okumura, Jeremy Phillips, Bernardo Pollak, Anke Reinders, Moritz Rövekamp, Ryosuke Sano, Shinichiro Sawa, Marc W Schmid, Makoto Shirakawa, Roberto Solano, Alexander Spunde, Noriyuki Suetsugu, Sumio Sugano, Akifumi Sugiyama, Rui Sun, Yutaka Suzuki, Mizuki Takenaka, Daisuke Takezawa, Hirokazu Tomogane, Masayuki Tsuzuki, Takashi Ueda, Masaaki Umeda, John M Ward, Yuichiro Watanabe, Kazufumi Yazaki, Ryusuke Yokoyama, Yoshihiro Yoshitake, Izumi Yotsui, Sabine Zachgo, Jeremy Schmutz
Feb 08, 2018
The evolution of land flora transformed the terrestrial environment. Land plants evolved from an ancestral charophycean alga from which they inherited developmental, biochemical, and cell biological attributes. Additional...
Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors.
Sarah J Horton, George Giotopoulos, Haiyang Yun, Shabana Vohra, Olivia Sheppard, Rachael Bashford-Rogers, Mamunur Rashid, Alexandra Clipson, Wai-In Chan, Daniel Sasca, Loukia Yiangou, Hikari Osaki, Faisal Basheer, Paolo Gallipoli, Natalie Burrows, Ayşegül Erdem, Anastasiya Sybirna, Sarah Foerster, Wanfeng Zhao, Tonci Sustic, Anna Petrunkina Harrison, Elisa Laurenti, Jessica Okosun, Daniel Hodson, Penny Wright, Ken G Smith, Patrick Maxwell, Jude Fitzgibbon, Ming Q Du, David J Adams, Brian JP Huntly
Apr 06, 2018
Loss-of-function mutations of cyclic-AMP response element binding protein, binding protein (CREBBP) are prevalent in lymphoid malignancies. However, the tumour suppressor functions of CREBBP remain unclear. We demonstrate that...
Acetylation Animals CREB-Binding Protein Cell Proliferation Cell Self Renewal Cell Transformation Neoplastic Cells Cultured DNA Damage Epigenesis Genetic Gene Expression Regulation Neoplastic Genetic Predisposition to Disease Histones Lymphangiogenesis Lymphoid Progenitor Cells Lymphoma lymphopoiesis Methylation Mice Mice Inbred C57BL Mice Knockout Mutation Neoplastic Stem Cells Phenotype Signal Transduction Time Factors Transcription Genetic Tumor Suppressor Protein p53
Genetic and transcriptional dissection of resistance to Claviceps purpurea in the durum wheat cultivar Greenshank.
Anna Gordon, Curt McCartney, Ron E Knox, Nelzo Ereful, Colin W Hiebert, David J Konkin, Ya-Chih Hsueh, Vijai Bhadauria, Mara Sgroi, Donal M O'Sullivan, Caroline Hadley, Lesley A Boyd, Jim G Menzies
Feb 13, 2021
A map of transcriptional heterogeneity and regulatory variation in human microglia.
Adam MH Young, Natsuhiko Kumasaka, Fiona Calvert, Timothy R Hammond, Andrew Knights, Nikolaos Panousis, Jun Sung Park, Jeremy Schwartzentruber, Jimmy Liu, Kousik Kundu, Michael Segel, Natalia A Murphy, Christopher E McMurran, Harry Bulstrode, Jason Correia, Karol P Budohoski, Alexis Joannides, Mathew R Guilfoyle, Rikin Trivedi, Ramez Kirollos, Robert Morris, Matthew R Garnett, Ivan Timofeev, Ibrahim Jalloh, Katherine Holland, Richard Mannion, Richard Mair, Colin Watts, Stephen J Price, Peter J Kirkpatrick, Thomas Santarius, Edward Mountjoy, Maya Ghoussaini, Nicole Soranzo, Omer A Bayraktar, Beth Stevens, Peter J Hutchinson, Robin Jm Franklin, Daniel J Gaffney
Dec 15, 2020
Genetic background drives transcriptional variation in human induced pluripotent stem cells.
Foad Rouhani, Natsuhiko Kumasaka, Miguel Cardoso de Brito, Allan Bradley, Ludovic Vallier, Daniel Gaffney
Oct 14, 2020
Human iPS cells have been generated using a diverse range of tissues from a variety of donors using different reprogramming vectors. However, these cell lines are heterogeneous, which presents a limitation for their use in...
Comparative Genomics
Duncan T Odom
Jan 31, 2020
Using a common analysis pipeline to compare data from three major lineages of complex eukaryotes reveals that transcription seems to evolve at a common rate.
TET2 Regulates the Neuroinflammatory Response in Microglia.
Alejandro Carrillo-Jimenez, Özgen Deniz, Maria Victoria Niklison-Chirou, Rocio Ruiz, Karina Bezerra-Salomão, Vassilis Stratoulias, Rachel Amouroux, Ping Kei Yip, Anna Vilalta, Mathilde Cheray, Alexander Michael Scott-Egerton, Eloy Rivas, Khadija Tayara, Irene García-Domínguez, Juan Garcia-Revilla, Juan Carlos Fernandez-Martin, Ana Maria Espinosa-Oliva, Xianli Shen, Peter St George-Hyslop, Guy Charles Brown, Petra Hajkova, Bertrand Joseph, Jose Luis Venero, Miguel Ramos Branco, Miguel Angel Burguillos
Oct 29, 2019
Epigenomic mechanisms regulate distinct aspects of the inflammatory response in immune cells. Despite the central role for microglia in neuroinflammation and neurodegeneration, little is known about their epigenomic regulation...
TET2 TLR-4 epigenetics metabolism Microglia Neuroinflammation Alzheimer Disease Amyloid Animals Brain DNA-Binding Proteins Dioxygenases Enhancer Elements Genetic Humans Interleukin-6 Lipopolysaccharides Male Mice Mice Inbred C57BL Mice Knockout Microglia Nitric Oxide Synthase Type II Proto-Oncogene Proteins RNA Interference RNA Small Interfering Rats Transcription Factor RelA Transcription Genetic
Genetic Variation in Complex Traits in Transgenic α-Synuclein Strains of Caenorhabditis elegans.
Different genetic backgrounds can modify the effect of mutated genes. Human α-synuclein (SNCA) gene encodes α-synuclein, and its oligomeric complexes accumulate with age and mediate the disruption of cellular homeostasis...
C. elegans Genetic background protein accumulation α-synuclein Animals Animals Genetically Modified Bacterial Proteins Body Size Caenorhabditis elegans Disease Models Animal Gene Expression Regulation genetic variation Genome Humans Luminescent Proteins Lysosomes Multifactorial Inheritance Parkinson Disease Transcription Genetic ALPHA-SYNUCLEIN
Mechanisms of stretch-mediated skin expansion at single-cell resolution.
Mariaceleste Aragona, Alejandro Sifrim, Milan Malfait, Yura Song, Jens Van Herck, Sophie Dekoninck, Souhir Gargouri, Gaëlle Lapouge, Benjamin Swedlund, Christine Dubois, Pieter Baatsen, Katlijn Vints, Seungmin Han, Fadel Tissir, Thierry Voet, Benjamin D Simons, Cédric Blanpain
Jun 09, 2020
Adaptor Proteins Signal Transducing Adherens Junctions Animals Base Sequence Cell Cycle Proteins Cell Differentiation Cell Self Renewal Chromatin Chromatin Assembly and Disassembly Clone Cells Disease Models Animal Extracellular Signal-Regulated MAP Kinases Gene Regulatory Networks Hydrogels Mechanotransduction Cellular Mice Mice Transgenic Mitogen-Activated Protein Kinase Kinases Mutation RNA Messenger RNA-seq Single-Cell Analysis Skin Stem Cells Trans-Activators Transcription Factor AP-1 Transcription Genetic YAP-Signaling Proteins
Stability and dynamics of polycomb target sites in Drosophila development.
Camilla Kwong, Boris Adryan, Ian Bell, Lisa Meadows, Steven Russell, J Robert Manak, Robert White
Mar 27, 2020
Polycomb-group (PcG) and Trithorax-group proteins together form a maintenance machinery that is responsible for stable heritable states of gene activity. While the best-studied target genes are the Hox genes of the Antennapedia...
Emerin modulates spatial organization of chromosome territories in cells on softer matrices.
Cells perceive and relay external mechanical forces into the nucleus through the nuclear envelope. Here we examined the effect of lowering substrate stiffness as a paradigm to address the impact of altered mechanical forces on...
Neuro-mesodermal progenitors (NMPs)
The mammalian embryo's caudal lateral epiblast (CLE) harbours bipotent progenitors, called neural mesodermal progenitors (NMPs), that contribute to the spinal cord and the paraxial mesoderm throughout axial elongation. Here, we...
neuromesodermal progenitors Single cells Transcription Animals Body Patterning Cell Differentiation Cell Lineage Embryo Mammalian Embryonic Stem Cells Female Gene Expression Profiling Gene Expression Regulation Developmental Germ Layers Green Fluorescent Proteins In Vitro Techniques Male Mesoderm Mice Neural Stem Cells Pluripotent Stem Cells Spinal Cord Stem Cells Support Vector Machine Transcriptome
DDX5 potentiates HIV-1 transcription as a co-factor of Tat.
BACKGROUND:HIV-1 does not encode a helicase and hijacks those of the cell for efficient replication. We and others previously showed that the DEAD box helicase, DDX5, is an essential HIV dependency factor. DDX5 was recently...
Published by: Retrovirology
Common and distinct transcriptional signatures of mammalian embryonic lethality.
John E Collins, Richard J White, Nicole Staudt, Ian M Sealy, Ian Packham, Neha Wali, Catherine Tudor, Cecilia Mazzeo, Angela Green, Emma Siragher, Edward Ryder, Jacqueline K White, Irene Papatheodoru, Amy Tang, Anja Füllgrabe, Konstantinos Billis, Stefan H Geyer, Wolfgang J Weninger, Antonella Galli, Myriam Hemberger, Derek L Stemple, Elizabeth Robertson, James C Smith, Timothy Mohun, David J Adams, Elisabeth M Busch-Nentwich
Aug 08, 2019
The Deciphering the Mechanisms of Developmental Disorders programme has analysed the morphological and molecular phenotypes of embryonic and perinatal lethal mouse mutant lines in order to investigate the causes of embryonic...
CTCF maintains regulatory homeostasis of cancer pathways.
Sarah J Aitken, Ximena Ibarra-Soria, Elissavet Kentepozidou, Paul Flicek, Christine Feig, John C Marioni, Duncan T Odom
Sep 20, 2018
CTCF Cancer Chromatin architecture chromatin state Hemizygosity Transcription Animals Breast Neoplasms CCCTC-Binding Factor Cell Line Chromatin DNA Neoplasm Enhancer Elements Genetic Female FIBROBLASTS Gene Expression Regulation Neoplastic Genome Hemizygote Homeostasis Humans Liver Neoplasms Experimental Mice Mice Inbred C57BL Mice Transgenic Protein Binding Signal Transduction Uterine Neoplasms
Transcriptional regulation of mammalian autophagy at a glance.
Macroautophagy, hereafter referred to as autophagy, is a catabolic process that results in the lysosomal degradation of cytoplasmic contents ranging from abnormal proteins to damaged cell organelles. It is activated under...
Protein aggregation of the p63 transcription factor underlies severe skin fragility in AEC syndrome.
Claudia Russo, Christian Osterburg, Anna Sirico, Dario Antonini, Raffaele Ambrosio, Julia Maren Würz, Jörg Rinnenthal, Marco Ferniani, Sebastian Kehrloesser, Birgit Schäfer, Peter Güntert, Satrajit Sinha, Volker Dötsch, Caterina Missero
Aug 31, 2018
AEC syndrome mouse model p63 protein aggregation Skin Animals Cleft Lip Cleft Palate Ectoderm Eye Abnormalities Frameshift Mutation HEK293 Cells Heterozygote Humans Mice Mutation Mutation Missense Phosphoproteins Protein Binding Protein Denaturation Skin Trans-Activators Transcription Factors Transcription Genetic Tumor Suppressor Proteins
Specificity of RNAi, LNA and CRISPRi as loss-of-function methods in transcriptional analysis.
Lovorka Stojic, Aaron TL Lun, Jasmin Mangei, Patrice Mascalchi, Valentina Quarantotti, Alexis R Barr, Chris Bakal, John C Marioni, Fanni Gergely, Duncan T Odom
Sep 05, 2018
The Helicase Aquarius/EMB-4 Is Required to Overcome Intronic Barriers to Allow Nuclear RNAi Pathways to Heritably Silence Transcription
A Akay, T Di Domenico, KM Suen, A Nabih, GE Parada, M Larance, R Medhi, Berkyurek, X Zhang, CJ Wedeles, Rudolph, J Engelhardt, M Hemberg, P Ma, AI Lamond, JM Claycomb, Miska
Jul 16, 2017
The global and promoter-centric 3D genome organization temporally resolved during a circadian cycle.
Mayra Furlan-Magaril, Masami Ando-Kuri, Rodrigo G Arzate-Mejía, Jörg Morf, Jonathan Cairns, Abraham Román-Figueroa, Luis Tenorio-Hernández, A César Poot-Hernández, Simon Andrews, Csilla Várnai, Boo Virk, Steven W Wingett, Peter Fraser
Jul 29, 2021
BACKGROUND: Circadian gene expression is essential for organisms to adjust their physiology and anticipate daily changes in the environment. The molecular mechanisms controlling circadian gene transcription are still under...
Chromatin compartments Circadian gene expression circadian rhythms Enhancers Genome 3D organization Promoter interactions TADs Transcription regulation Animals Base Sequence Biological Clocks Chromatin Circadian Rhythm Enhancer Elements Genetic Gene Expression Regulation Genome Liver Male Mice Inbred C57BL Models Genetic Promoter Regions Genetic Time Factors Transcription Genetic
Composition of Transcription Machinery and Its Crosstalk with Nucleoid-Associated Proteins and Global Transcription Factors.
The coordination of bacterial genomic transcription involves an intricate network of interdependent genes encoding nucleoid-associated proteins (NAPs), DNA topoisomerases, RNA polymerase subunits and modulators of transcription...
Progesterone receptor modulates ERα action in breast cancer.
Hisham Mohammed, I Alasdair Russell, Rory Stark, Oscar M Rueda, Theresa E Hickey, Gerard A Tarulli, Aurelien A Serandour, Stephen N Birrell, Alejandra Bruna, Amel Saadi, Suraj Menon, James Hadfield, Michelle Pugh, Ganesh V Raj, Gordon D Brown, Clive D'Santos, Jessica LL Robinson, Grace Silva, Rosalind Launchbury, Charles M Perou, John Stingl, Carlos Caldas, Wayne D Tilley, Jason S Carroll
Aug 13, 2015
Animals Breast Neoplasms Cell Line Tumor Cell Proliferation Chromatin DNA Copy Number Variations Disease Progression Estrogen Receptor alpha Estrogens Female Gene Expression Regulation Neoplastic Humans Ligands Mice Progesterone Protein Binding Receptors Progesterone Transcription Genetic Xenograft Model Antitumor Assays
Differential gene expression profile in the small intestines of mice lacking pacemaker interstitial cells of Cajal.
Yataro Daigo, Ichiro Takayama, Bruce AJ Ponder, Carlos Caldas, Sean M Ward, Kenton M Sanders, Masayuki A Fujino
Jun 16, 2011
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