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Base Pairing Humans Molecular Dynamics Simulation Myotonic Dystrophy RNA RNA-Binding Proteins Thermodynamics Trinucleotide Repeats

The type II restriction endonuclease TseI recognizes the DNA target sequence 5'-G^CWGC-3' (where W = A or T) and cleaves after the first G to produce fragments with three-base 5'-overhangs. We have determined that it is a...

adenine Base Pair Mismatch DNA DNA Cleavage Deoxyribonucleases Type II Site-Specific Thymine Trinucleotide Repeats

Huntington's disease is a late-onset neurodegenerative disease caused by a CAG trinucleotide repeat in the gene encoding the huntingtin protein. Despite its well-defined genetic origin, the molecular and cellular mechanisms...

Gene Expression Regulation Humans Huntingtin Protein Huntington Disease Nerve Tissue Proteins Nuclear Proteins Trinucleotide Repeats

INTRODUCTION: The androgen receptor (AR) gene exon 1 CAG repeat polymorphism encodes a string of 9-32 glutamines. Women with germline BRCA1 mutations who carry at least one AR allele with 28 or more repeats have been reported to...

Breast Neoplasms DNA Mutational Analysis Exons Female Genes BRCA1 Genes BRCA2 Genetic Predisposition to Disease Genotype Germ-Line Mutation Humans Polymerase Chain Reaction Polymorphism Genetic Receptors Androgen Risk Assessment Trinucleotide Repeats

Alleles Computational Biology Genetic Association Studies Genetic Predisposition to Disease Genome Human Genomic Instability Humans Microsatellite Instability Molecular Sequence Annotation Nervous System Diseases Neurodevelopmental Disorders Polymorphism Genetic Trinucleotide Repeat Expansion Trinucleotide Repeats

metabolism allelic series Behaviour Diabetes Preconditioning aging Animals Cognitive Dysfunction Disease Models Animal Female Humans Huntington Disease Male Mice Nitro Compounds Propionates Succinate Dehydrogenase Trinucleotide Repeats

CLINICAL NEUROLOGY HUNTINGTON'S MOVEMENT DISORDERS statistics Age of Onset Cohort Studies Disability Evaluation Disease Progression Female Humans Huntington Disease Male Middle Aged Models Biological Reproducibility of Results Trinucleotide Repeats

BACKGROUND: In the R6/2 mouse model of Huntington's disease (HD), expansion of the CAG trinucleotide repeat length beyond about 300 repeats induces a novel phenotype associated with a reduction in transcription of the transgene....

Animals DNA DNA Single-Stranded Exons Gene Expression Regulation Genotype Humans Huntingtin Protein Huntington Disease Inverted Repeat Sequences Mice Microscopy Atomic Force Mutation Nerve Tissue Proteins Nuclear Proteins Nucleic Acid Conformation Polymerase Chain Reaction Site-Specific DNA-Methyltransferase (Adenine-Specific) Transcription Genetic Trinucleotide Repeats

MRI MRS Neurodegenerative disease tensor-based morphometry trinucleotide repeat disorders Animals Aspartic Acid Brain Disease Models Animal Disease Progression Glutamic Acid Humans Huntingtin Protein Huntington Disease Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Mice Mice Transgenic Trinucleotide Repeats

Huntington’s disease (HD) is an autosomal dominant neurodegenerative condition caused by trinucleotide CAG repeat expansion in the huntingtin gene. CAG lengths of more than 35 repeats are associated with disease, whilst CAG...

Humans Huntingtin Protein Huntington Disease Trinucleotide Repeat Expansion Trinucleotide Repeats

Humans RNA Interference Trinucleotide Repeat Expansion Trinucleotide Repeats Huntington Disease RNA Messenger Huntingtin Protein