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A brain proteomic investigation of rapamycin effects in the Tsc1+/- mouse model.
BACKGROUND: Tuberous sclerosis complex (TSC) is a rare monogenic disorder characterized by benign tumors in multiple organs as well as a high prevalence of epilepsy, intellectual disability and autism. TSC is caused by...
A brain proteomic investigation of rapamycin effects in the <i>Tsc1</i><sup>+/-</sup> mouse model.
Hippocampus Frontal Lobe Animals Mice Mice Mutant Strains Tuberous sclerosis Disease Models Animal Sirolimus Tumor Suppressor Proteins Nerve Tissue Proteins Proteomics Tuberous Sclerosis Complex 1 Protein
Published by: Molecular autism
A minimally invasive, lentiviral based method for the rapid and sustained genetic manipulation of renal tubules.
mTORC1 Upregulation Leads to Accumulation of the Oncometabolite Fumarate in a Mouse Model of Renal Cell Carcinoma.
Luca Drusian, Elisa Agnese Nigro, Valeria Mannella, Roberto Pagliarini, Monika Pema, Ana SH Costa, Fabio Benigni, Alessandro Larcher, Marco Chiaravalli, Edoardo Gaude, Francesco Montorsi, Umberto Capitanio, Giovanna Musco, Christian Frezza, Alessandra Boletta
Nov 01, 2018
Renal cell carcinomas (RCCs) are common cancers diagnosed in more than 350,000 people each year worldwide. Several pathways are de-regulated in RCCs, including mTORC1. However, how mTOR drives tumorigenesis in this context is...
TCA cycle cancer metabolism cancer signaling epithelial transformation Fumarate Hydratase Metabolic reprogramming papillary carcinoma rapamycin renal cancer renal cysts Animals Carcinoma Renal Cell Cells Cultured Female Fumarate Hydratase Fumarates Humans Kidney Neoplasms Male Mechanistic Target of Rapamycin Complex 1 Mice Mice Inbred C57BL Tuberous Sclerosis Complex 1 Protein Up-Regulation