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Results: 101
Somatic mutant clones colonize the human esophagus with age.
Iñigo Martincorena, Joanna C Fowler, Agnieszka Wabik, Andrew RJ Lawson, Federico Abascal, Michael WJ Hall, Alex Cagan, Kasumi Murai, Krishnaa Mahbubani, Michael R Stratton, Rebecca C Fitzgerald, Penny A Handford, Peter J Campbell, Kourosh Saeb-Parsy, Philip H Jones
Dec 06, 2018
Conserved Helix-Flanking Prolines Modulate Intrinsically Disordered Protein
Michael D Crabtree, Wade Borcherds, Anusha Poosapati, Sarah L Shammas, Gary W Daughdrill, Jane Clarke
Mar 26, 2018
Appropriate integration of cellular signals requires a delicate balance of ligand-target binding affinities. Increasing the level of residual structure in intrinsically disordered proteins (IDPs), which are overrepresented in...
Amino Acid Sequence Animals Binding Sites Cloning Molecular Conserved Sequence Escherichia coli Gene Expression Histone-Lysine N-Methyltransferase Humans Intrinsically Disordered Proteins Membrane Proteins Mice Models Molecular Mutation Myeloid-Lymphoid Leukemia Protein Phosphoproteins Proline Protein Binding Protein Conformation alpha-Helical Protein Folding Protein Interaction Domains and Motifs Recombinant Proteins Sequence Alignment Sequence Homology Amino Acid Tumor Suppressor Protein p53
Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors.
Sarah J Horton, George Giotopoulos, Haiyang Yun, Shabana Vohra, Olivia Sheppard, Rachael Bashford-Rogers, Mamunur Rashid, Alexandra Clipson, Wai-In Chan, Daniel Sasca, Loukia Yiangou, Hikari Osaki, Faisal Basheer, Paolo Gallipoli, Natalie Burrows, Ayşegül Erdem, Anastasiya Sybirna, Sarah Foerster, Wanfeng Zhao, Tonci Sustic, Anna Petrunkina Harrison, Elisa Laurenti, Jessica Okosun, Daniel Hodson, Penny Wright, Ken G Smith, Patrick Maxwell, Jude Fitzgibbon, Ming Q Du, David J Adams, Brian JP Huntly
Apr 06, 2018
Loss-of-function mutations of cyclic-AMP response element binding protein, binding protein (CREBBP) are prevalent in lymphoid malignancies. However, the tumour suppressor functions of CREBBP remain unclear. We demonstrate that...
Acetylation Animals CREB-Binding Protein Cell Proliferation Cell Self Renewal Cell Transformation Neoplastic Cells Cultured DNA Damage Epigenesis Genetic Gene Expression Regulation Neoplastic Genetic Predisposition to Disease Histones Lymphangiogenesis Lymphoid Progenitor Cells Lymphoma lymphopoiesis Methylation Mice Mice Inbred C57BL Mice Knockout Mutation Neoplastic Stem Cells Phenotype Signal Transduction Time Factors Transcription Genetic Tumor Suppressor Protein p53
αE-catenin is a candidate tumor suppressor for the development of E-cadherin-expressing lobular-type breast cancer.
Jolien S de Groot, Max Ak Ratze, Miranda van Amersfoort, Tanja Eisemann, Eva J Vlug, Mijanou T Niklaas, Suet-Feung Chin, Carlos Caldas, Paul J van Diest, Jos Jonkers, Johan de Rooij, Patrick WB Derksen
Sep 10, 2018
Although mutational inactivation of E-cadherin (CDH1) is the main driver of invasive lobular breast cancer (ILC), approximately 10-15% of all ILCs retain membrane-localized E-cadherin despite the presence of an apparent...
E-cadherin Rho/Rock lobular breast cancer mouse model α-catenin (CTNNA1) Actomyosin Adherens Junctions Animals Anoikis Antigens CD Breast Neoplasms Cadherins Carcinoma Lobular Cell Adhesion Cell Proliferation Cell Shape Female Gene Expression Regulation Neoplastic Genetic Predisposition to Disease Humans MCF-7 Cells Mice Knockout Mutation Neoplasm Invasiveness Phenotype Signal Transduction Tumor Suppressor Protein p53 Tumor Suppressor Proteins alpha Catenin rho GTP-Binding Proteins rho-Associated Kinases
The use of panel testing in familial breast and ovarian cancer.
Advances in sequencing technology have led to the introduction of panel testing in hereditary breast and ovarian cancer. While direct-to-consumer testing services have become widely available, the clinical validity of many of...
Breast Cancer gene panel genetic testing and hereditary cancer ovarian cancer AMP-Activated Protein Kinase Kinases Antigens CD Cadherins DNA-Binding Proteins Epithelial Cell Adhesion Molecule Female Genes BRCA1 Genes BRCA2 Genetic Predisposition to Disease Genetic Testing Hereditary Breast and Ovarian Cancer Syndrome High-Throughput Nucleotide Sequencing Humans Li-Fraumeni Syndrome Lynch Syndrome II MutL Protein Homolog 1 MutS Homolog 2 Protein PTEN Phosphohydrolase Peutz-Jeghers Syndrome Protein Serine-Threonine Kinases Sequence Analysis DNA Tumor Suppressor Protein p53
Exome Sequencing of Uterine Leiomyosarcomas Identifies Frequent Mutations in TP53, ATRX, and MED12.
Netta Mäkinen, Mervi Aavikko, Tuomas Heikkinen, Minna Taipale, Jussi Taipale, Riitta Koivisto-Korander, Ralf Bützow, Pia Vahteristo
Jan 03, 2020
Uterine leiomyosarcomas (ULMSs) are aggressive smooth muscle tumors associated with poor clinical outcome. Despite previous cytogenetic and molecular studies, their molecular background has remained elusive. To examine somatic...
Adaptor Proteins Signal Transducing Aged Aged 80 and over Co-Repressor Proteins DNA Helicases Exome Female Gene Expression Regulation Neoplastic High-Throughput Nucleotide Sequencing Humans Leiomyosarcoma Mediator Complex Middle Aged Molecular Chaperones Mutation Rate Nuclear Proteins Telomere Homeostasis Tumor Suppressor Protein p53 Uterine Neoplasms X-linked Nuclear Protein
Establishment and Characterization of a Brca1-/-, p53-/- Mouse Mammary Tumor Cell Line.
Lilla Hámori, Gyöngyi Kudlik, Kornélia Szebényi, Nóra Kucsma, Bálint Szeder, Ádám Póti, Ferenc Uher, György Várady, Dávid Szüts, József Tóvári, András Füredi, Gergely Szakács
Apr 27, 2020
Breast cancer is the most commonly occurring cancer in women and the second most common cancer overall. By the age of 80, the estimated risk for breast cancer for women with germline BRCA1 or BRCA2 mutations is around 80%....
P53 autoantibodies in 1006 patients followed up for breast cancer.
Adult Aged Antineoplastic Combined Chemotherapy Protocols Autoantibodies Autoantigens Breast Neoplasms Chemotherapy Adjuvant Clinical Trials as Topic Cohort Studies Disease Progression Enzyme-Linked Immunosorbent Assay Female Follow-Up Studies Humans Mastectomy Menopause Middle Aged Neoplasm Proteins Tamoxifen Treatment Outcome Tumor Suppressor Protein p53
p53 activity contributes to defective interfollicular epidermal differentiation in hyperproliferative murine skin.
Multilocus Inherited Neoplasia Alleles Syndrome
James Whitworth, Anne-Bine Skytte, Lone Sunde, Derek H Lim, Mark J Arends, Lisa Happerfield, Ian M Frayling, Rick van Minkelen, Emma R Woodward, Marc D Tischkowitz, Eamonn R Maher
Mar 23, 2016
Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation.
David Fernandez-Antoran, Gabriel Piedrafita, Kasumi Murai, Swee Hoe Ong, Albert Herms, Christian Frezza, Philip H Jones
Jul 23, 2019
As humans age, normal tissues, such as the esophageal epithelium, become a patchwork of mutant clones. Some mutations are under positive selection, conferring a competitive advantage over wild-type cells. We speculated that...
NFE2L2 TP53 cell competition cell tracing DIFFERENTIATION ionizing radiation Mitochondria Oxidative Stress Somatic mutation stem cell aging Animals antioxidants Cell Differentiation Cell Proliferation Cells Cultured Epithelial Cells esophagus Humans Mice Mice Transgenic Mutation NF-E2-Related Factor 2 Oxidation-Reduction Oxidative Stress RADIATION Ionizing Receptors Estrogen Tumor Suppressor Protein p53
Heterogeneity of Myc expression in breast cancer exposes pharmacological vulnerabilities revealed through executable mechanistic modeling.
Peter Kreuzaler, Matthew A Clarke, Elizabeth J Brown, Catherine H Wilson, Roderik M Kortlever, Nir Piterman, Trevor Littlewood, Gerard I Evan, Jasmin Fisher
Oct 14, 2019
Cells with higher levels of Myc proliferate more rapidly and supercompetitively eliminate neighboring cells. Nonetheless, tumor cells in aggressive breast cancers typically exhibit significant and stable heterogeneity in their...
The molecular landscape of Asian breast cancers reveals clinically relevant population-specific differences.
Jia-Wern Pan, Muhammad Mamduh Ahmad Zabidi, Pei-Sze Ng, Mei-Yee Meng, Siti Norhidayu Hasan, Bethan Sandey, Stephen-John Sammut, Cheng-Har Yip, Pathmanathan Rajadurai, Oscar M Rueda, Carlos Caldas, Suet-Feung Chin, Soo-Hwang Teo
Nov 02, 2020
Examining the contribution of smoking and HPV towards the etiology of oral cavity squamous cell carcinoma using high-throughput sequencing
Andrew P Zammit, Rohit Sinha, Caroline L Cooper, Christopher FL Perry, Ian H Frazer, Zewen K Tuong
Sep 02, 2019
Oral cavity Squamous Cell Carcinoma (OCSCC) is a common form of head and neck cancer throughout the developed and developing world. However, the etiology of OCSCC is still unclear. Here, we explored the extent to which tobacco...
Adult Aged Aged 80 and over Carcinoma Squamous Cell Cyclin-Dependent Kinase Inhibitor p16 Female Gene Expression Profiling Gene Expression Regulation Neoplastic High-Throughput Nucleotide Sequencing Humans Male Middle Aged Mouth Neoplasms Mutation Papillomaviridae Papillomavirus Infections Prospective Studies Sequence Analysis RNA Smoking Tumor Suppressor Protein p53 Exome Sequencing
Aberrant anaplastic lymphoma kinase activity induces a p53 and Rb-dependent senescence-like arrest in the absence of detectable p53 stabilization.
Anaplastic Lymphoma Kinase (ALK) is a receptor tyrosine kinase aberrantly expressed in a variety of tumor types, most notably in Anaplastic Large Cell Lymphoma (ALCL) where a chromosomal translocation generates the oncogenic...
Anaplastic Lymphoma Kinase Animals Cell Adhesion Cell Cycle Cell Proliferation Cell Transformation Neoplastic Cells Cultured Cellular Senescence Cyclin-Dependent Kinase Inhibitor p16 Embryo Mammalian FIBROBLASTS Humans Mice Models Biological Mutation Protein Processing Post-Translational Protein Stability Protein-Tyrosine Kinases Receptor Protein-Tyrosine Kinases Retinoblastoma Protein Transcription Genetic Tumor Suppressor Protein p53
ATM, ATR, and DNA-PK
In vertebrate cells, the DNA damage response is controlled by three related kinases: ATM, ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be identified. During this time, our...
Animals Antineoplastic Agents Ataxia Telangiectasia Mutated Proteins Calcium-Binding Proteins Cell Nucleus DNA Damage DNA Repair Enzyme Activation History 20th Century History 21st Century Humans Models Molecular Neoplasms Phosphorylation Protein Conformation Protein Kinase Inhibitors Signal Transduction Structure-Activity Relationship Tumor Suppressor Protein p53
Exploratory Analysis of $\textit{TP53}$ Mutations in Circulating Tumour DNA as Biomarkers of Treatment Response for Patients with Relapsed High-Grade Serous Ovarian Carcinoma
CA Parkinson, D Gale, AM Piskorz, H Biggs, C Hodgkin, H Addley, S Freeman, P Moyle, E Sala, K Sayal, K Hosking, I Gounaris, M Jimenez-Linan, HM Earl, W Qian, N Rosenfeld, JD Brenton
Feb 02, 2017
Non-SMC condensin I complex proteins control chromosome segregation and survival of proliferating cells in the zebrafish neural retina.
Sabine Seipold, Florian C Priller, Paul Goldsmith, William A Harris, Herwig Baier, Salim Abdelilah-Seyfried
Jun 13, 2011
Micro(mi) RNA-34a targets protein phosphatase (PP)1γ to regulate DNA damage tolerance.
ATM DNA damage response Cancer cancer therapy ionising radiation miR-34a miRNA p53 protein phosphatase protein phosphatase 1γ 3' Untranslated Regions Algorithms Blotting Western Cell Line Tumor DNA Damage Gene Expression Regulation Neoplastic Humans MicroRNAs Phosphorylation Protein Phosphatase 1 RADIATION Ionizing Tumor Suppressor Protein p53
CHK1 Inhibition Synergizes with Gemcitabine Initially by Destabilizing the DNA Replication Apparatus.
Siang-Boon Koh, Aurélie Courtin, Richard J Boyce, Robert G Boyle, Frances M Richards, Duncan I Jodrell
Jul 02, 2015
p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1.
Mar Quiñones, Omar Al-Massadi, Cintia Folgueira, Stephan Bremser, Rosalía Gallego, Leonardo Torres-Leal, Roberta Haddad-Tóvolli, Cristina García-Caceres, Rene Hernandez-Bautista, Brian YH Lam, Daniel Beiroa, Estrella Sanchez-Rebordelo, Ana Senra, Jose A Malagon, Patricia Valerio, Marcos F Fondevila, Johan Fernø, Maria M Malagon, Raian Contreras, Paul Pfluger, Jens C Brüning, Giles Yeo, Matthias Tschöp, Carlos Diéguez, Miguel López, Marc Claret, Peter Kloppenburg, Guadalupe Sabio, Ruben Nogueiras
Sep 10, 2018
p53 is a well-known tumor suppressor that has emerged as an important player in energy balance. However, its metabolic role in the hypothalamus remains unknown. Herein, we show that mice lacking p53 in agouti-related peptide...
Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry.
Krishna Sharma, Alexander V Strizhak, Elaine Fowler, Xuelu Wang, Wenshu Xu, Claus Hatt Jensen, Yuteng Wu, Hannah F Sore, Yu Heng Lau, Marko Hyvönen, Laura S Itzhaki, David R Spring
Aug 21, 2019
The Sondheimer dialkyne is extensively used in double strain-promoted azide-alkyne cycloadditions. This reagent suffers with poor water-solubility and rapidly decomposes in aqueous solutions. This intrinsically limits its...
Refined cut-off for TP53 immunohistochemistry improves prediction of TP53 mutation status in ovarian mucinous tumors
Eun Young Kang, Dane Cheasley, Cecile LePage, Matthew J Wakefield, Michelle da Cunha Torres, Simone Rowley, Carolina Salazar, Zhongyue Xing, Prue Allan, David DL Bowtell, Anne-Marie Mes-Masson, Diane M Provencher, Kurosh Rahimi, Linda E Kelemen, Peter A Fasching, Jennifer A Doherty, Marc T Goodman, Ellen L Goode, Suha Deen, Paul DP Pharoah, James D Brenton, Weiva Sieh, Constantina Mateoiu, Karin Sundfeldt, Linda S Cook, Nhu D Le, Michael S Anglesio, C Blake Gilks, David G Huntsman, Catherine J Kennedy, Nadia Traficante, Australian Ovarian Cancer Study, Anna DeFazio, Scott Kaufmann, Michael Churchman, Charlie Gourley, Andrew N Stephens, Nicola S Meagher, Susan J Ramus, Yoland C Antill, Ian Campbell, Clare L Scott, Martin Köbel, Kylie L Gorringe, GAMuT Collaborators
Jul 07, 2020
Adult Australia Biomarkers Tumor DNA Mutational Analysis Female Humans Immunohistochemistry Middle Aged Mutation Neoplasms Cystic Mucinous and Serous North America Observer Variation Ovarian Neoplasms Predictive Value of Tests Prognosis Reproducibility of Results Risk Assessment Risk Factors Tissue Array Analysis Tumor Suppressor Protein p53 United Kingdom
Germline TP53 mutations undergo copy number gain years prior to tumor diagnosis.
Nicholas Light, Mehdi Layeghifard, Ayush Attery, Vallijah Subasri, Matthew Zatzman, Nathaniel D Anderson, Rupal Hatkar, Sasha Blay, David Chen, Ana Novokmet, Fabio Fuligni, James Tran, Richard de Borja, Himanshi Agarwal, Larissa Waldman, Lisa M Abegglen, Daniel Albertson, Jonathan L Finlay, Jordan R Hansford, Sam Behjati, Anita Villani, Moritz Gerstung, Ludmil B Alexandrov, Gino R Somers, Joshua D Schiffman, Varda Rotter, David Malkin, Adam Shlien
Feb 09, 2023
Li-Fraumeni syndrome (LFS) is a hereditary cancer predisposition syndrome associated with germline TP53 pathogenic variants. Here, we perform whole-genome sequence (WGS) analysis of tumors from 22 patients with TP53 germline...
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