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Integrative Molecular Characterization of Malignant Pleural Mesothelioma.
Julija Hmeljak, Francisco Sanchez-Vega, Katherine A Hoadley, Juliann Shih, Chip Stewart, David Heiman, Patrick Tarpey, Ludmila Danilova, Esther Drill, Ewan A Gibb, Reanne Bowlby, Rupa Kanchi, Hatice U Osmanbeyoglu, Yoshitaka Sekido, Jumpei Takeshita, Yulia Newton, Kiley Graim, Manaswi Gupta, Carl M Gay, Lixia Diao, David L Gibbs, Vesteinn Thorsson, Lisa Iype, Havish Kantheti, David T Severson, Gloria Ravegnini, Patrice Desmeules, Achim A Jungbluth, William D Travis, Sanja Dacic, Lucian R Chirieac, Françoise Galateau-Sallé, Junya Fujimoto, Aliya N Husain, Henrique C Silveira, Valerie W Rusch, Robert C Rintoul, Harvey Pass, Hedy Kindler, Marjorie G Zauderer, David J Kwiatkowski, Raphael Bueno, Anne S Tsao, Jenette Creaney, Tara Lichtenberg, Kristen Leraas, Jay Bowen, TCGA Research Network, Ina Felau, Jean Claude Zenklusen, Rehan Akbani, Andrew D Cherniack, Lauren A Byers, Michael S Noble, Jonathan A Fletcher, A Gordon Robertson, Ronglai Shen, Hiroyuki Aburatani, Bruce W Robinson, Peter Campbell, Marc Ladanyi
Dec 17, 2018
Malignant pleural mesothelioma (MPM) is a highly lethal cancer of the lining of the chest cavity. To expand our understanding of MPM, we conducted a comprehensive integrated genomic study, including the most detailed analysis of...
Protein aggregation of the p63 transcription factor underlies severe skin fragility in AEC syndrome.
Claudia Russo, Christian Osterburg, Anna Sirico, Dario Antonini, Raffaele Ambrosio, Julia Maren Würz, Jörg Rinnenthal, Marco Ferniani, Sebastian Kehrloesser, Birgit Schäfer, Peter Güntert, Satrajit Sinha, Volker Dötsch, Caterina Missero
Aug 31, 2018
AEC syndrome mouse model p63 protein aggregation Skin Animals Cleft Lip Cleft Palate Ectoderm Eye Abnormalities Frameshift Mutation HEK293 Cells Heterozygote Humans Mice Mutation Mutation Missense Phosphoproteins Protein Binding Protein Denaturation Skin Trans-Activators Transcription Factors Transcription Genetic Tumor Suppressor Proteins
αE-catenin is a candidate tumor suppressor for the development of E-cadherin-expressing lobular-type breast cancer.
Jolien S de Groot, Max Ak Ratze, Miranda van Amersfoort, Tanja Eisemann, Eva J Vlug, Mijanou T Niklaas, Suet-Feung Chin, Carlos Caldas, Paul J van Diest, Jos Jonkers, Johan de Rooij, Patrick WB Derksen
Sep 10, 2018
Although mutational inactivation of E-cadherin (CDH1) is the main driver of invasive lobular breast cancer (ILC), approximately 10-15% of all ILCs retain membrane-localized E-cadherin despite the presence of an apparent...
E-cadherin Rho/Rock lobular breast cancer mouse model α-catenin (CTNNA1) Actomyosin Adherens Junctions Animals Anoikis Antigens CD Breast Neoplasms Cadherins Carcinoma Lobular Cell Adhesion Cell Proliferation Cell Shape Female Gene Expression Regulation Neoplastic Genetic Predisposition to Disease Humans MCF-7 Cells Mice Knockout Mutation Neoplasm Invasiveness Phenotype Signal Transduction Tumor Suppressor Protein p53 Tumor Suppressor Proteins alpha Catenin rho GTP-Binding Proteins rho-Associated Kinases
Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control.
Yavuz Kulaberoglu, Kui Lin, Maxine Holder, Zhongchao Gai, Marta Gomez, Belul Assefa Shifa, Merdiye Mavis, Lily Hoa, Ahmad AD Sharif, Celia Lujan, Ewan St John Smith, Ivana Bjedov, Nicolas Tapon, Geng Wu, Alexander Hergovich
Jul 12, 2018
The Hippo tumor suppressor pathway is essential for development and tissue growth control, encompassing a core cassette consisting of the Hippo (MST1/2), Warts (LATS1/2), and Tricornered (NDR1/2) kinases together with MOB1 as an...
Clinical and pathological associations of PTEN expression in ovarian cancer
Filipe Correia Martins, Dominique-Laurent Couturier, Anna Paterson, Anthony N Karnezis, Christine Chow, Tayyebeh M Nazeran, Adekunle Odunsi, Aleksandra Gentry-Maharaj, Aleksandra Vrvilo, Alexander Hein, Aline Talhouk, Ana Osorio, Andreas D Hartkopf, Angela Brooks-Wilson, Anna DeFazio, Anna Fischer, Arndt Hartmann, Brenda Y Hernandez, Bryan M McCauley, Chloe Karpinskyj, Christiani B de Sousa, Claus Høgdall, Daniel G Tiezzi, Esther Herpel, Florin Andrei Taran, Francesmary Modugno, Gary Keeney, Gregg Nelson, Helen Steed, Honglin Song, Hugh Luk, Javier Benitez, Jennifer Alsop, Jennifer M Koziak, Jenny Lester, Joseph H Rothstein, Jurandyr M de Andrade, Lene Lundvall, Luis Paz-Ares, Luis Robles-Díaz, Lynne R Wilkens, Maria J Garcia, Maria P Intermaggio, Marie-Lyne Alcaraz, Mary A Brett, Matthias W Beckmann, Mercedes Jimenez-Linan, Michael Anglesio, Michael E Carney, Michael Schneider, Nadia Traficante, Nadja Pejovic, Naveena Singh, Nhu Le, Peter Sinn, Prafull Ghatage, Ramona Erber, Robert Edwards, Robert Vierkant, Roberta B Ness, Samuel Leung, Sandra Orsulic, Sara Y Brucker, Scott H Kaufmann, Sian Fereday, Simon Gayther, Stacey J Winham, Stefan Kommoss, Tanja Pejovic, Teri A Longacre, Valerie McGuire, Valerie Rhenius, Weiva Sieh, Yurii B Shvetsov, Alice S Whittemore, Annette Staebler, Beth Y Karlan, Cristina Rodriguez-Antona, David D Bowtell, Ellen L Goode, Estrid Høgdall, Francisco J Candido Dos Reis, Jacek Gronwald, Jenny Chang-Claude, Kirsten B Moysich, Linda E Kelemen, Linda S Cook, Marc T Goodman, Peter A Fasching, Robin Crawford, Suha Deen, Usha Menon, David G Huntsman, Martin Köbel, Susan J Ramus, Paul DP Pharoah, James D Brenton
Mar 06, 2020
BACKGROUND: PTEN loss is a putative driver in histotypes of ovarian cancer (high-grade serous (HGSOC), endometrioid (ENOC), clear cell (CCOC), mucinous (MOC), low-grade serous (LGSOC)). We aimed to characterise PTEN expression...
Adenocarcinoma Clear Cell Age Factors Biomarkers Tumor Carcinoma Ovarian Epithelial Cohort Studies Down-Regulation Female Gene Knockout Techniques Humans Middle Aged Neoplasm Staging Ovarian Neoplasms PTEN Phosphohydrolase Prospective Studies Receptors Androgen Receptors Estrogen Receptors Progesterone Tissue Array Analysis Tumor Suppressor Proteins
Multilocus Inherited Neoplasia Alleles Syndrome
James Whitworth, Anne-Bine Skytte, Lone Sunde, Derek H Lim, Mark J Arends, Lisa Happerfield, Ian M Frayling, Rick van Minkelen, Emma R Woodward, Marc D Tischkowitz, Eamonn R Maher
Mar 23, 2016
Grey wolf genomic history reveals a dual ancestry of dogs.
Anders Bergström, David WG Stanton, Ulrike H Taron, Laurent Frantz, Mikkel-Holger S Sinding, Erik Ersmark, Saskia Pfrengle, Molly Cassatt-Johnstone, Ophélie Lebrasseur, Linus Girdland-Flink, Daniel M Fernandes, Morgane Ollivier, Leo Speidel, Shyam Gopalakrishnan, Michael V Westbury, Jazmin Ramos-Madrigal, Tatiana R Feuerborn, Ella Reiter, Joscha Gretzinger, Susanne C Münzel, Pooja Swali, Nicholas J Conard, Christian Carøe, James Haile, Anna Linderholm, Semyon Androsov, Ian Barnes, Chris Baumann, Norbert Benecke, Hervé Bocherens, Selina Brace, Ruth F Carden, Dorothée G Drucker, Sergey Fedorov, Mihály Gasparik, Mietje Germonpré, Semyon Grigoriev, Pam Groves, Stefan T Hertwig, Varvara V Ivanova, Luc Janssens, Richard P Jennings, Aleksei K Kasparov, Irina V Kirillova, Islam Kurmaniyazov, Yaroslav V Kuzmin, Pavel A Kosintsev, Martina Lázničková-Galetová, Charlotte Leduc, Pavel Nikolskiy, Marc Nussbaumer, Cóilín O'Drisceoil, Ludovic Orlando, Alan Outram, Elena Y Pavlova, Angela R Perri, Małgorzata Pilot, Vladimir V Pitulko, Valerii V Plotnikov, Albert V Protopopov, André Rehazek, Mikhail Sablin, Andaine Seguin-Orlando, Jan Storå, Christian Verjux, Victor F Zaibert, Grant Zazula, Philippe Crombé, Anders J Hansen, Eske Willerslev, Jennifer A Leonard, Anders Götherström, Ron Pinhasi, Verena J Schuenemann, Michael Hofreiter, M Thomas P Gilbert, Beth Shapiro, Greger Larson, Johannes Krause, Love Dalén, Pontus Skoglund
Aug 01, 2022
The grey wolf (Canis lupus) was the first species to give rise to a domestic population, and they remained widespread throughout the last Ice Age when many other large mammal species went extinct. Little is known, however, about...
Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer.
Timothy J Humpton, Brinda Alagesan, Gina M DeNicola, Dan Lu, Georgi N Yordanov, Carl S Leonhardt, Melissa A Yao, Priya Alagesan, Maya N Zaatari, Youngkyu Park, Jeremy N Skepper, Kay F Macleod, Pedro A Perez-Mancera, Michael P Murphy, Gerard I Evan, Karen H Vousden, David A Tuveson
Oct 29, 2019
Animals Carcinoma Pancreatic Ductal Cell Line Tumor Gene Expression Regulation Neoplastic Glycolysis Humans Membrane Proteins Mice Mitochondria mitophagy Mutation NADP Neoplasm Transplantation Oxidation-Reduction Pancreatic Neoplasms Proto-Oncogene Proteins Proto-Oncogene Proteins p21(ras) Tumor Suppressor Proteins
Regulation of B Lymphocyte Development by Histone H2A Deubiquitinase BAP1.
Yun Hsiao Lin, Yue Liang, Hanchen Wang, Lin Tze Tung, Michael Förster, Poorani Ganesh Subramani, Javier M Di Noia, Simon Clare, David Langlais, Anastasia Nijnik
Jun 07, 2021
BAP1 is a deubiquitinase (DUB) of the Ubiquitin C-terminal Hydrolase (UCH) family that regulates gene expression and other cellular processes, via deubiquitination of histone H2AK119ub and other substrates. BAP1 is an important...
B Cell Development B cells epigenetic regulation Mouse models Transcriptional regulation Animals B-Lymphocytes Cell Lineage Cell Proliferation Cells Cultured Epigenesis Genetic Female Gene Expression Regulation Developmental Histones Lymphocyte Activation Male Mice Inbred C57BL Mice Knockout Phenotype Precursor Cells B-Lymphoid Protein Processing Post-Translational Transcription Genetic Tumor Suppressor Proteins Ubiquitin Thiolesterase Ubiquitination
A kinase-independent function of PAK is crucial for pathogen-mediated actin remodelling.
The p21-activated kinase (PAK) family regulate a multitude of cellular processes, including actin cytoskeleton remodelling. Numerous bacterial pathogens usurp host signalling pathways that regulate actin reorganisation in order...
ZNF185 is a p63 target gene critical for epidermal differentiation and squamous cell carcinoma development.
Artem Smirnov, Anna Maria Lena, Angela Cappello, Emanuele Panatta, Lucia Anemona, Simone Bischetti, Margherita Annicchiarico-Petruzzelli, Alessandro Mauriello, Gerry Melino, Eleonora Candi
Nov 20, 2018
Antigens CD Cadherins Carcinoma Squamous Cell Cell Adhesion Cell Differentiation Cells Cultured Cytoskeletal Proteins Down-Regulation Enhancer Elements Genetic Epithelial Cells Gene Expression Profiling Gene Expression Regulation Neoplastic Humans Keratinocytes LIM Domain Proteins Models Biological Sequence Analysis RNA Transcription Factors Tumor Suppressor Proteins
The Drosophila homologue of CTIP1 (Bcl11a) and CTIP2 (Bcl11b) regulates neural stem cell temporal patterning.
Complex inhibitory effects of nitric oxide on autophagy.
Sovan Sarkar, Viktor I Korolchuk, Maurizio Renna, Sara Imarisio, Angeleen Fleming, Andrea Williams, Moises Garcia-Arencibia, Claudia Rose, Shouqing Luo, Benjamin R Underwood, Guido Kroemer, Cahir J O'Kane, David C Rubinsztein
Jan 04, 2018
Autophagy, a major degradation process for long-lived and aggregate-prone proteins, affects various human processes, such as development, immunity, cancer, and neurodegeneration. Several autophagy regulators have been identified...
Animals Apoptosis Regulatory Proteins Autophagy Beclin-1 Cell Line Class III Phosphatidylinositol 3-Kinases Enzyme Inhibitors HEK293 Cells HeLa Cells Humans Huntingtin Protein Huntington Disease I-kappa B Kinase Mechanistic Target of Rapamycin Complex 1 Membrane Proteins Mice Mitogen-Activated Protein Kinase 8 Multiprotein Complexes NG-Nitroarginine Methyl Ester Nerve Tissue Proteins Nitric oxide nitric oxide synthase Nuclear Proteins Phosphorylation Protein Isoforms Proteins Proto-Oncogene Proteins c-bcl-2 Rats TOR Serine-Threonine Kinases Tuberous Sclerosis Complex 2 Protein Tumor Suppressor Proteins
CRIB effector disorder
CRIB effectors Intrinsically Disordered Proteins Protein Conformation small G-proteins Animals GTP Phosphohydrolases GTP-Binding Proteins Gene Expression Regulation Humans Hydrophobic and Hydrophilic Interactions Membrane Proteins Nonlinear dynamics Polylysine Protein Binding Protein Domains Protein Structure Quaternary Signal Transduction Static Electricity Tumor Suppressor Proteins cdc42 GTP-Binding Protein rac1 GTP-Binding Protein
Risk score predicts high-grade prostate cancer in DNA-methylation positive, histopathologically negative biopsies.
Leander Van Neste, Alan W Partin, Grant Stewart, Jonathan I Epstein, David J Harrison, Wim Van Criekinge
Apr 13, 2016
DNA Methylation epigenetics high-grade logistic regression prostate neoplasms repeat biopsy significant cancer Adenomatous Polyposis Coli Aged Biopsy Needle DNA Methylation Epigenesis Genetic False Negative Reactions Glutathione S-Transferase pi Humans Male Middle Aged Neoplasm Grading Prostate Prostate-specific antigen Prostatic Neoplasms Risk Factors Tumor Suppressor Proteins
Conversion of the LIMA1 tumour suppressor into an oncogenic LMO-like protein by API2-MALT1 in MALT lymphoma.
Zilin Nie, Ming-Qing Du, Linda M McAllister-Lucas, Peter C Lucas, Nathanael G Bailey, Cory M Hogaboam, Megan S Lim, Kojo SJ Elenitoba-Johnson
Feb 02, 2015
NDRG2 Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain.
Motaz M Fadul, Claire J Garwood, Rachel Waller, Navonna Garrett, Paul R Heath, Fiona E Matthews, Carol Brayne, Stephen B Wharton, Julie E Simpson
Jan 10, 2020
N-myc downstream regulated gene 2 (NDRG2) Ageing brain astrocyte Neurofibrillary Tangles Aged Aged 80 and over aging Alzheimer Disease Antigens CD Antigens Differentiation Myelomonocytic Astrocytes Brain DNA Damage Excitatory Amino Acid Transporter 2 Gene Expression Regulation Glial Fibrillary Acidic Protein Glutamate-Ammonia Ligase Humans Microglia Neurofibrillary Tangles Tumor Suppressor Proteins tau Proteins
Proteomic Analysis of GLUT4 Storage Vesicles Reveals Tumor Suppressor Candidate 5 (TUSC5) as a Novel Regulator of Insulin Action in Adipocytes.
Daniel J Fazakerley, Sheyda Naghiloo, Rima Chaudhuri, Françoise Koumanov, James G Burchfield, Kristen C Thomas, James R Krycer, Matthew J Prior, Ben L Parker, Beverley A Murrow, Jacqueline Stöckli, Christopher C Meoli, Geoffrey D Holman, David E James
Aug 28, 2020
Insulin signaling augments glucose transport by regulating glucose transporter 4 (GLUT4) trafficking from specialized intracellular compartments, termed GLUT4 storage vesicles (GSVs), to the plasma membrane. Proteomic analysis...
Population-based estimates of age-specific cumulative risk of breast cancer for pathogenic variants in ATM.
Anne-Laure Renault, James G Dowty, Jason A Steen, Shuai Li, Ingrid M Winship, Graham G Giles, John L Hopper, Melissa C Southey, Tú Nguyen-Dumont
May 09, 2022
BACKGROUND: Multigene panel tests for breast cancer predisposition routinely include ATM as it is now a well-established breast cancer predisposition gene. METHODS: We included ATM in a multigene panel test applied to the...
Identification of aceNKPs, a committed common progenitor population of the ILC1 and NK cell continuum.
Noe Rodriguez-Rodriguez, Paula A Clark, Mayuri Gogoi, Ana CF Ferreira, Bernhard Kerscher, Alastair Crisp, Helen E Jolin, Jane E Murphy, Meera Sivasubramaniam, Luisa Pedro, Jennifer A Walker, Morgan WD Heycock, Jacqueline D Shields, Jillian L Barlow, Andrew NJ McKenzie
Jan 12, 2023
Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication.
Iosifina P Foskolou, Christian Jorgensen, Katarzyna B Leszczynska, Monica M Olcina, Hanna Tarhonskaya, Bauke Haisma, Vincenzo D'Angiolella, William K Myers, Carmen Domene, Emily Flashman, Ester M Hammond
May 11, 2020
Cells exposed to hypoxia experience replication stress but do not accumulate DNA damage, suggesting sustained DNA replication. Ribonucleotide reductase (RNR) is the only enzyme capable of de novo synthesis of deoxyribonucleotide...
DNA damage response p53 RNR RRM2B Hypoxia Nucleotides radiosensitivity replication stress Animals Apoptosis Cell Cycle Proteins Colonic Neoplasms DNA Damage DNA Replication DNA Neoplasm Female HCT116 Cells Humans Mice Inbred BALB C Mice Nude Oxygen RNA Interference Radiation Tolerance Ribonucleoside Diphosphate Reductase Ribonucleotide Reductases Time Factors Transfection Tumor Burden Tumor Hypoxia Tumor Suppressor Proteins Xenograft Model Antitumor Assays
Genomics and clinical correlates of renal cell carcinoma.
PURPOSE: Clear cell, papillary cell, and chromophobe renal cell carcinomas (RCCs) have now been well characterised thanks to large collaborative projects such as The Cancer Genome Atlas (TCGA). Not only has knowledge of the...
evolution Genomics mutations Prognosis renal cancer Therapy Carcinoma Renal Cell DNA-Binding Proteins Genomics Histone-Lysine N-Methyltransferase Humans Kidney Neoplasms Mutation Nuclear Proteins PTEN Phosphohydrolase Telomerase Transcription Factors Tumor Suppressor Protein p53 Tumor Suppressor Proteins Ubiquitin Thiolesterase Von Hippel-Lindau Tumor Suppressor Protein
Role of Non-Native Electrostatic Interactions in the Coupled Folding and Binding of PUMA with Mcl-1
Common variants in the ATM, BRCA1, BRCA2, CHEK2 and TP53 cancer susceptibility genes are unlikely to increase breast cancer risk.
Caroline Baynes, Catherine S Healey, Karen A Pooley, Serena Scollen, Robert N Luben, Deborah J Thompson, Paul DP Pharoah, Douglas F Easton, Bruce AJ Ponder, Alison M Dunning, SEARCH breast cancer study
Jun 17, 2011
Adult Aged Ataxia Telangiectasia Mutated Proteins Breast Neoplasms Cell Cycle Proteins Checkpoint Kinase 2 DNA-Binding Proteins Female Genes BRCA1 Genes BRCA2 Genes p53 Genetic Predisposition to Disease Haplotypes Humans Middle Aged Polymorphism Single Nucleotide Protein Serine-Threonine Kinases risk Tumor Suppressor Proteins
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