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Pros and cons of different therapeutic antibody formats for recombinant antivenom development.
Andreas H Laustsen, José María Gutiérrez, Cecilie Knudsen, Kristoffer H Johansen, Erick Bermúdez-Méndez, Felipe A Cerni, Jonas A Jürgensen, Line Ledsgaard, Andrea Martos-Esteban, Mia Øhlenschlæger, Urska Pus, Mikael R Andersen, Bruno Lomonte, Mikael Engmark, Manuela B Pucca
Jun 19, 2018
Antibody technologies are being increasingly applied in the field of toxinology. Fuelled by the many advances in immunology, synthetic biology, and antibody research, different approaches and antibody formats are being...
Adverse reactions Animal envenoming Antibodies Antibody expression Antivenom Antivenom design Biotechnology Immunogenicity Neglected tropical diseases pharmacodynamics Pharmacokinetics Recombinant antivenom Scorpion sting Snakebite Spider bite Venom Venom neutralization Animals Antibodies Antivenins Camelus Humans Recombinant Proteins Venoms
Developmentally regulated expression, alternative splicing and distinct sub-groupings in members of the Schistosoma mansoni venom allergen-like (SmVAL) gene family.
Iain W Chalmers, Andrew J McArdle, Richard Mr Coulson, Marissa A Wagner, Ralf Schmid, Hirohisa Hirai, Karl F Hoffmann
Jun 16, 2011
Allergens Alternative Splicing Amino Acid Sequence Animals Cloning Molecular DNA Complementary evolution Molecular Exons Gene Expression Regulation Developmental Genes Helminth Helminth Proteins Introns Multigene Family Phylogeny Schistosoma mansoni Sequence Analysis Protein Sequence Homology Amino Acid Species Specificity Venoms
A comparative genomics multitool for scientific discovery and conservation.
Zoonomia Consortium
Dec 24, 2020
The Zoonomia Project is investigating the genomics of shared and specialized traits in eutherian mammals. Here we provide genome assemblies for 131 species, of which all but 9 are previously uncharacterized, and describe a...
Animals Biodiversity Biomedical Research Conservation of Natural Resources Eutheria evolution Molecular Extinction Biological Genetic Speciation genetic variation Genomics Humans Infections Knowledge Discovery Loss of Heterozygosity Neoplasms Phylogeny Risk Assessment selection Genetic Sequence Alignment Species Specificity Venoms