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Results: 40
Rme-8 depletion perturbs Notch recycling and predisposes to pathogenic signaling.
Emily R Rowe, Michael L Mimmack, Antonio D Barbosa, Afreen Haider, Iona Isaac, Myriam M Ouberai, Abdou Rachid Thiam, Satish Patel, Vladimir Saudek, Symeon Siniossoglou, David B Savage
Jan 13, 2016
11-mer repeat amphipathic helix lipid droplet lipodystrophy Lipolysis membrane membrane targeting monolayer perilipin phospholipid Amino Acid Sequence Animals Binding Sites Biological Transport COS Cells Carrier Proteins Chlorocebus aethiops Gene Expression Humans Hydrophobic and Hydrophilic Interactions Lipid Droplets Membrane Proteins Micelles Models Molecular Molecular Sequence Data Mutation Perilipin-1 Perilipin-2 Perilipin-3 Phosphoproteins Protein Binding Protein Interaction Domains and Motifs Protein Structure Secondary Protein Transport Recombinant Proteins Saccharomyces cerevisiae Sequence Alignment Transgenes Vesicular Transport Proteins
Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.
Morag R Hunter, Geoffrey G Hesketh, Tomasz H Benedyk, Anne-Claude Gingras, Stephen C Graham
Sep 05, 2018
A combination of urinary biomarker panel and PancRISK score for earlier detection of pancreatic cancer
Silvana Debernardi, Harrison O'Brien, Asma S Algahmdi, Nuria Malats, Grant D Stewart, Marija Plješa-Ercegovac, Eithne Costello, William Greenhalf, Amina Saad, Rhiannon Roberts, Alexander Ney, Stephen P Pereira, Hemant M Kocher, Stephen Duffy, Oleg Blyuss, Tatjana Crnogorac-Jurcevic
Nov 23, 2020
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, with around 9% of patients surviving >5 years. Asymptomatic in its initial stages, PDAC is mostly diagnosed late, when already a locally...
Adult Aged Aged 80 and over Antigens Tumor-Associated Carbohydrate Biomarkers Tumor Carcinoma Pancreatic Ductal Early Detection of Cancer Europe Female Humans Lithostathine Male Middle Aged Pancreatic Neoplasms Predictive Value of Tests Reproducibility of Results Retrospective Studies Trefoil Factor-1 Urinalysis Vesicular Transport Proteins Young Adult
Mechanism and evolution of the Zn-fingernail required for interaction of VARP with VPS29.
Harriet Crawley-Snowdon, Ji-Chun Yang, Nathan R Zaccai, Luther J Davis, Lena Wartosch, Emily K Herman, Nicholas A Bright, James S Swarbrick, Brett M Collins, Lauren P Jackson, Matthew NJ Seaman, J Paul Luzio, Joel B Dacks, David Neuhaus, David J Owen
Sep 14, 2020
Genes and lipids that impact uptake and assimilation of exogenous coenzyme Q in Saccharomyces cerevisiae.
Lucía Fernández-Del-Río, Miranda E Kelly, Jaime Contreras, Michelle C Bradley, Andrew M James, Michael P Murphy, Gregory S Payne, Catherine F Clarke
May 14, 2020
Coenzyme Q (CoQ) is an essential player in the respiratory electron transport chain and is the only lipid-soluble antioxidant synthesized endogenously in mammalian and yeast cells. In humans, genetic mutations, pathologies...
CoQ(6) rescue coenzyme Q Endocytosis Saccharomyces cerevisiae transport Ubiquinone Uptake Animals GTP-Binding Proteins Humans Lipids Microfilament Proteins Mitochondrial Diseases N-Terminal Acetyltransferase B Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins Ubiquinone Vesicular Transport Proteins
Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS.
Veselina Petrova, Craig S Pearson, Jared Ching, James R Tribble, Andrea G Solano, Yunfei Yang, Fiona M Love, Robert J Watt, Andrew Osborne, Evan Reid, Pete A Williams, Keith R Martin, Herbert M Geller, Richard Eva, James W Fawcett
Sep 22, 2020
Animals Axons Cells Cultured Central Nervous System Endoplasmic Reticulum Endosomes Female Humans Integrins Mice Mice Inbred C57BL Mutation Nerve Regeneration Neurons Neuroprotective Agents Optic Nerve Injuries Phosphorylation Protein Domains Rats Rats Sprague-Dawley Retina Vesicular Transport Proteins
Mauve/LYST limits fusion of lysosome-related organelles and promotes centrosomal recruitment of microtubule nucleating proteins.
Lysosome-related organelles (LROs) are endosomal compartments carrying tissue-specific proteins, which become enlarged in Chediak-Higashi syndrome (CHS) due to mutations in LYST. Here, we show that Drosophila Mauve, a...
Chediak-Higashi syndrome Drosophila LYST centrosomes endosomal vesicle trafficking lysosome-related organelles mauve microtubule nucleation minispindles/Ch-TOG Animals Cell Line Centrosome Chediak-Higashi Syndrome Cytoplasmic Granules Drosophila Drosophila Proteins Female Humans Lysosomes Microtubule-Associated Proteins Microtubules Mutation Oocytes Spindle Apparatus Vesicular Transport Proteins
Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes.
Sar1 GTPase Activity Is Regulated by Membrane Curvature.
Michael G Hanna, Ioanna Mela, Lei Wang, Robert M Henderson, Edwin R Chapman, J Michael Edwardson, Anjon Audhya
Dec 08, 2015
COPII GTPase endoplasmic reticulum (ER) membrane bilayer membrane transport Amino Acid Substitution Animals COP-Coated Vesicles Caenorhabditis elegans Caenorhabditis elegans Proteins Endoplasmic Reticulum Enzyme Inhibitors GTP Phosphohydrolases GTPase-Activating Proteins Guanosine Triphosphate Guanylyl Imidodiphosphate Humans Lipid Bilayers Membrane Microdomains Microscopy Atomic Force Models Biological Monomeric GTP-Binding Proteins Mutation Organelle Shape RNA Interference Receptor Protein-Tyrosine Kinases Recombinant Proteins Vesicular Transport Proteins ras GTPase-Activating Proteins
Network of protein interactions within the Drosophila inner kinetochore.
Magdalena M Richter, Jaroslaw Poznanski, Anna Zdziarska, Mariusz Czarnocki-Cieciura, Zoltan Lipinszki, Michal Dadlez, David M Glover, Marcin R Przewloka
Feb 03, 2016
HDX-MS Centromere CHROMOSOME kinetochore Mitosis structure Amino Acid Sequence Animals Centromere Chromosomal Proteins Non-Histone Drosophila Drosophila Proteins Kinetochores Microtubules Models Molecular Molecular Sequence Data Nuclear Proteins Protein Binding Protein Conformation Protein Interaction Domains and Motifs Protein Interaction Mapping Protein Interaction Maps Protein Multimerization Sequence Alignment Transcription Factors Vesicular Transport Proteins
Cryo-EM structure of metazoan TRAPPIII, the multi-subunit complex that activates the GTPase Rab1.
The TRAPP complexes are nucleotide exchange factors that play essential roles in membrane traffic and autophagy. TRAPPII activates Rab11, and TRAPPIII activates Rab1, with the two complexes sharing a core of small subunits that...
The COP II adaptor protein TMED7 is required to initiate and mediate the delivery of TLR4 to the plasma membrane.
Amino Acid Motifs Animals Cell Membrane Cytoplasm Cytosol Endoplasmic Reticulum Flow Cytometry Golgi Apparatus HEK293 Cells Humans Inflammation Ligands Microscopy Confocal Microscopy Fluorescence Mutagenesis Myeloid Differentiation Factor 88 Protein Structure Tertiary Signal Transduction Toll-Like Receptor 4 Vesicular Transport Proteins
CCDC88A mutations cause PEHO-like syndrome in humans and mouse.
Michael S Nahorski, Masato Asai, Emma Wakeling, Alasdair Parker, Naoya Asai, Natalie Canham, Susan E Holder, Ya-Chun Chen, Joshua Dyer, Angela F Brady, Masahide Takahashi, C Geoffrey Woods
Feb 10, 2016
Thermodynamic mapping of effector protein interfaces with RalA and RalB.
Louise J Campbell, Maria Peppa, Michael D Crabtree, Arooj Shafiq, Nicholas F McGough, Helen R Mott, Darerca Owen
May 27, 2016
Retromer and Its Role in Regulating Signaling at Endosomes.
Matthew NJ Seaman
Feb 11, 2019
The retromer complex is a key element of the endosomal protein sorting machinery being involved in trafficking of proteins from endosomes to the Golgi and also endosomes to the cell surface. There is now accumulating evidence...
SRGN, a new identified shear-stress-responsive gene in endothelial cells.
Qinfeng Ma, Wei Gu, Tianhan Li, Kun Zhang, Yuliang Cui, Kai Qu, Nan Wang, Rose Humphry, Colm Durkan, Juhui Qiu, Guixue Wang
Aug 03, 2020
Endothelial cells (ECs) play an important role in the pathogenesis of cardiovascular disease, especially atherosclerosis (AS). The abnormal wall shear stress (WSS) which directly contacts with ECs is the key stimulating factor...
Atherosclerosis Bioinformatics Endothelial Cells SRGN Shear stress Animals Atherosclerosis Endothelium Vascular Human Umbilical Vein Endothelial Cells Humans Mechanotransduction Cellular Mice Mice Knockout ApoE Neovascularization Pathologic Proteoglycans Shear strength Stress Mechanical Vesicular Transport Proteins
Transcriptome-wide association study of breast cancer risk by estrogen-receptor status.
Helian Feng, Alexander Gusev, Bogdan Pasaniuc, Lang Wu, Jirong Long, Zomoroda Abu-Full, Kristiina Aittomäki, Irene L Andrulis, Hoda Anton-Culver, Antonis C Antoniou, Adalgeir Arason, Volker Arndt, Kristan J Aronson, Banu K Arun, Ella Asseryanis, Paul L Auer, Jacopo Azzollini, Judith Balmaña, Rosa B Barkardottir, Daniel R Barnes, Daniel Barrowdale, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Katarzyna Białkowska, Ana Blanco, Carl Blomqvist, Bram Boeckx, Natalia V Bogdanova, Stig E Bojesen, Manjeet K Bolla, Bernardo Bonanni, Ake Borg, Hiltrud Brauch, Hermann Brenner, Ignacio Briceno, Annegien Broeks, Thomas Brüning, Barbara Burwinkel, Qiuyin Cai, Trinidad Caldés, Maria A Caligo, Ian Campbell, Sander Canisius, Daniele Campa, Brian D Carter, Jonathan Carter, Jose E Castelao, Jenny Chang-Claude, Stephen J Chanock, Hans Christiansen, Wendy K Chung, Kathleen BM Claes, Christine L Clarke, GEMO Study Collaborators, EMBRACE Collaborators, GC-HBOC Study Collaborators, Fergus J Couch, Angela Cox, Simon S Cross, Cezary Cybulski, Kamila Czene, Mary B Daly, Miguel de la Hoya, Kim De Leeneer, Joe Dennis, Peter Devilee, Orland Diez, Susan M Domchek, Thilo Dörk, Isabel dos-Santos-Silva, Alison M Dunning, Miriam Dwek, Diana M Eccles, Bent Ejlertsen, Carolina Ellberg, Christoph Engel, Mikael Eriksson, Peter A Fasching, Olivia Fletcher, Henrik Flyger, Florentia Fostira, Eitan Friedman, Lin Fritschi, Debra Frost, Marike Gabrielson, Patricia A Ganz, Susan M Gapstur, Judy Garber, Montserrat García-Closas, José A García-Sáenz, Mia M Gaudet, Graham G Giles, Gord Glendon, Andrew K Godwin, Mark S Goldberg, David E Goldgar, Anna González-Neira, Mark H Greene, Jacek Gronwald, Pascal Guénel, Christopher A Haiman, Per Hall, Ute Hamann, Christopher Hake, Wei He, Jane Heyworth, Frans BL Hogervorst, Antoinette Hollestelle, Maartje J Hooning, Robert N Hoover, John L Hopper, Guanmengqian Huang, Peter J Hulick, Keith Humphreys, Evgeny N Imyanitov, ABCTB Investigators, HEBON Investigators, BCFR Investigators, OCGN Investigators, Claudine Isaacs, Milena Jakimovska, Anna Jakubowska, Paul James, Ramunas Janavicius, Rachel C Jankowitz, Esther M John, Nichola Johnson, Vijai Joseph, Audrey Jung, Beth Y Karlan, Elza Khusnutdinova, Johanna I Kiiski, Irene Konstantopoulou, Vessela N Kristensen, Yael Laitman, Diether Lambrechts, Conxi Lazaro, Dominique Leroux, Goska Leslie, Jenny Lester, Fabienne Lesueur, Noralane Lindor, Sara Lindström, Wing-Yee Lo, Jennifer T Loud, Jan Lubiński, Enes Makalic, Arto Mannermaa, Mehdi Manoochehri, Siranoush Manoukian, Sara Margolin, John WM Martens, Maria E Martinez, Laura Matricardi, Tabea Maurer, Dimitrios Mavroudis, Lesley McGuffog, Alfons Meindl, Usha Menon, Kyriaki Michailidou, Pooja M Kapoor, Austin Miller, Marco Montagna, Fernando Moreno, Lidia Moserle, Anna M Mulligan, Taru A Muranen, Katherine L Nathanson, Susan L Neuhausen, Heli Nevanlinna, Ines Nevelsteen, Finn C Nielsen, Liene Nikitina-Zake, Kenneth Offit, Edith Olah, Olufunmilayo I Olopade, Håkan Olsson, Ana Osorio, Janos Papp, Tjoung-Won Park-Simon, Michael T Parsons, Inge S Pedersen, Ana Peixoto, Paolo Peterlongo, Julian Peto, Paul DP Pharoah, Kelly-Anne Phillips, Dijana Plaseska-Karanfilska, Bruce Poppe, Nisha Pradhan, Karolina Prajzendanc, Nadege Presneau, Kevin Punie, Katri Pylkäs, Paolo Radice, Johanna Rantala, Muhammad Usman Rashid, Gad Rennert, Harvey A Risch, Mark Robson, Atocha Romero, Emmanouil Saloustros, Dale P Sandler, Catarina Santos, Elinor J Sawyer, Marjanka K Schmidt, Daniel F Schmidt, Rita K Schmutzler, Minouk J Schoemaker, Rodney J Scott, Priyanka Sharma, Xiao-Ou Shu, Jacques Simard, Christian F Singer, Anne-Bine Skytte, Penny Soucy, Melissa C Southey, John J Spinelli, Amanda B Spurdle, Jennifer Stone, Anthony J Swerdlow, William J Tapper, Jack A Taylor, Manuel R Teixeira, Mary Beth Terry, Alex Teulé, Mads Thomassen, Kathrin Thöne, Darcy L Thull, Marc Tischkowitz, Amanda E Toland, Rob AEM Tollenaar, Diana Torres, Thérèse Truong, Nadine Tung, Celine M Vachon, Christi J van Asperen, Ans Mw van den Ouweland, Elizabeth J van Rensburg, Ana Vega, Alessandra Viel, Paula Vieiro-Balo, Qin Wang, Barbara Wappenschmidt, Clarice R Weinberg, Jeffrey N Weitzel, Camilla Wendt, Robert Winqvist, Xiaohong R Yang, Drakoulis Yannoukakos, Argyrios Ziogas, Roger L Milne, Douglas F Easton, Georgia Chenevix-Trench, Wei Zheng, Peter Kraft, Xia Jiang
Mar 12, 2020
Previous transcriptome-wide association studies (TWAS) have identified breast cancer risk genes by integrating data from expression quantitative loci and genome-wide association studies (GWAS), but analyses of breast cancer...
LC3-positive structures are prominent in autophagy-deficient cells.
Gautam Runwal, Eleanna Stamatakou, Farah H Siddiqi, Claudia Puri, Ye Zhu, David C Rubinsztein
Jul 02, 2019
AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A.
Alexandra K Davies, Daniel N Itzhak, James R Edgar, Tara L Archuleta, Jennifer Hirst, Lauren P Jackson, Margaret S Robinson, Georg HH Borner
Dec 13, 2018
Adaptor protein 4 (AP-4) is an ancient membrane trafficking complex, whose function has largely remained elusive. In humans, AP-4 deficiency causes a severe neurological disorder of unknown aetiology. We apply unbiased proteomic...
Gorab is a Golgi protein required for structure and duplication of Drosophila centrioles.
Levente Kovacs, Jennifer Chao-Chu, Sandra Schneider, Marco Gottardo, George Tzolovsky, Nikola S Dzhindzhev, Maria Giovanna Riparbelli, Giuliano Callaini, David M Glover
Mar 07, 2019
Regulation of cargo-selective endocytosis by dynamin 2 GTPase-activating protein girdin.
Liang Weng, Atsushi Enomoto, Hiroshi Miyoshi, Kiyofumi Takahashi, Naoya Asai, Nobuhiro Morone, Ping Jiang, Jian An, Takuya Kato, Keisuke Kuroda, Takashi Watanabe, Masato Asai, Maki Ishida-Takagishi, Yoshiki Murakumo, Hideki Nakashima, Kozo Kaibuchi, Masahide Takahashi
May 28, 2019
In clathrin-mediated endocytosis (CME), specificity and selectivity for cargoes are thought to be tightly regulated by cargo-specific adaptors for distinct cellular functions. Here, we show that the actin-binding protein girdin...
Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy.
Kevin Moreau, Ghita Ghislat, Warren Hochfeld, Maurizio Renna, Eszter Zavodszky, Gautam Runwal, Claudia Puri, Shirley Lee, Farah Siddiqi, Fiona M Menzies, Brinda Ravikumar, David C Rubinsztein
Jun 07, 2016
Nbeal2 interacts with Dock7, Sec16a, and Vac14.
Louisa Mayer, Maria Jasztal, Mercedes Pardo, Salvadora Aguera de Haro, Janine Collins, Tadbir K Bariana, Peter A Smethurst, Luigi Grassi, Romina Petersen, Paquita Nurden, Rémi Favier, Lu Yu, Stuart Meacham, William J Astle, Jyoti Choudhary, Wyatt W Yue, Willem H Ouwehand, Jose A Guerrero
Mar 16, 2018
Mutations in NBEAL2, the gene encoding the scaffolding protein Nbeal2, are causal of gray platelet syndrome (GPS), a rare recessive bleeding disorder characterized by platelets lacking α-granules and progressive marrow fibrosis....
Mammalian autophagy and the plasma membrane.
Autophagy (literally 'self-eating') is an evolutionarily conserved degradation process where cytoplasmic components are engulfed by vesicles called autophagosomes, which are then delivered to lysosomes, where their contents are...
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