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Inhibition of the RNA polymerase III-mediated dsDNA-sensing pathway of innate immunity by vaccinia virus protein E3.
The vaccinia virus E3 protein is an important intracellular modulator of innate immunity that can be split into distinct halves. The C terminus contains a well defined dsRNA-binding domain, whereas the N terminus contains a...
Quantitative Temporal Proteomic Analysis of Vaccinia Virus Infection Reveals Regulation of Histone Deacetylases by an Interferon Antagonist.
Lior Soday, Yongxu Lu, Jonas D Albarnaz, Colin TR Davies, Robin Antrobus, Geoffrey L Smith, Michael P Weekes
Apr 16, 2019
Histone deacetylase host-pathogen interaction Immune Evasion innate immunity interferon Poxvirus quantitative proteomics restriction factor systems virology tandem mass tag Cytomegalovirus Down-Regulation Gene Expression Regulation Viral Herpesvirus 1 Human Histone Deacetylases Host-Pathogen Interactions Humans Immune Evasion Interferons Membrane Proteins Proteasome Endopeptidase Complex Proteolysis Proteomics Time Factors Vaccinia vaccinia virus Viral Proteins
Epstein-Barr virus nuclear antigen EBNA-LP is essential for transforming naïve B cells, and facilitates recruitment of transcription factors to the viral genome.
Agnieszka Szymula, Richard D Palermo, Amr Bayoumy, Ian J Groves, Mohammed Ba Abdullah, Beth Holder, Robert E White
Jul 31, 2018
The Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) is the first viral latency-associated protein produced after EBV infection of resting B cells. Its role in B cell transformation is poorly defined, but it has...
Adult B-Lymphocytes Cell Transformation Viral Cells Cultured Epstein-Barr Virus Infections Female Gene Expression Regulation Viral Genome Viral HEK293 Cells Herpesvirus 4 Human Humans Infant Newborn Leukemia B-Cell Pregnancy Promoter Regions Genetic Protein Binding Transcription Factors Viral Proteins
Expression of the UL16 glycoprotein of Human Cytomegalovirus protects the virus-infected cell from attack by natural killer cells.
Circulation of reassortant influenza A(H7N9) viruses in poultry and humans, Guangdong Province, China, 2013.
Changwen Ke, Jing Lu, Jie Wu, Dawei Guan, Lirong Zou, Tie Song, Lina Yi, Xianqiao Zeng, Lijun Liang, Hanzhong Ni, Min Kang, Xin Zhang, Haojie Zhong, Jianfeng He, Jinyan Lin, Derek Smith, David Burke, Ron AM Fouchier, Marion Koopmans, Yonghui Zhang
Nov 13, 2014
Adolescent Adult Aged Animals China Environmental Monitoring Female Genome Viral Geography Medical Hemagglutinin Glycoproteins Influenza Virus High-Throughput Nucleotide Sequencing Humans Influenza A virus H7N9 Subtype Influenza in Birds Influenza Human Male Middle Aged Neuraminidase Phylogeny Phylogeography Poultry Public Health Surveillance Reassortant Viruses Viral Proteins Young Adult
Norovirus translation requires an interaction between the C Terminus of the genome-linked viral protein VPg and eukaryotic translation initiation factor 4G.
Liliane Chung, Dalan Bailey, Eoin N Leen, Edward P Emmott, Yasmin Chaudhry, Lisa O Roberts, Stephen Curry, Nicolas Locker, Ian G Goodfellow
Jul 09, 2014
Eukaryotic Translation Initiation Factor 4E (eIF4E) Norovirus Plus-stranded RNA Virus Translation Translation Initiation Factor VPg Virus eIF4G Base Sequence Chromatography Affinity DNA Primers Eukaryotic Initiation Factor-4G Genome Viral Norovirus Polymerase Chain Reaction Protein Binding Protein Biosynthesis Proteomics Viral Proteins
Quantitative Proteomics Analysis of Lytic KSHV Infection in Human Endothelial Cells Reveals Targets of Viral Immune Modulation.
HHV-8 KSHV NK cell receptor ligands herpesvirus host cell restriction factors lytic reactivation Proteomics Viral immune evasion Antigens Differentiation T-Lymphocyte Cell Line DNA-Directed DNA Polymerase Down-Regulation Endothelial Cells Gene Library Gene Ontology Genes Viral Genetic Testing Herpesvirus 8 Human Humans immunomodulation Kinetics Ligands Mutation Proteome Proteomics Sarcoma Kaposi Up-Regulation Viral Proteins Virus Activation eIF-2 Kinase
Metagenomic analyses and genetic diversity of Tomato leaf curl Arusha virus affecting tomato plants in Kenya.
Edith Khamonya Avedi, Adedapo Olutola Adediji, Dora Chao Kilalo, Florence Mmogi Olubayo, Isaac Macharia, Elijah Miinda Ateka, Eunice Magoma Machuka, Josiah Musembi Mutuku
Jan 07, 2021
A protease-activatable luminescent biosensor and reporter cell line for authentic SARS-CoV-2 infection.
Pehuén Pereyra Gerber, Lidia M Duncan, Edward JD Greenwood, Sara Marelli, Adi Naamati, Ana Teixeira-Silva, Thomas WM Crozier, Ildar Gabaev, Jun R Zhan, Thomas E Mulroney, Emily C Horner, Rainer Doffinger, Anne E Willis, James ED Thaventhiran, Anna V Protasio, Nicholas J Matheson
Mar 13, 2022
The Interplay between ESCRT and Viral Factors in the Enveloped Virus Life Cycle.
Viruses are obligate parasites that rely on host cellular factors to replicate and spread. The endosomal sorting complexes required for transport (ESCRT) system, which is classically associated with sorting and downgrading...
The missing link
Robert A Nicholls, Marcin Wojdyr, Robbie P Joosten, Lucrezia Catapano, Fei Long, Marcus Fischer, Paul Emsley, Garib N Murshudov
May 24, 2021
Covalent linkages between constituent blocks of macromolecules and ligands have been subject to inconsistent treatment during the model-building, refinement and deposition process. This may stem from a number of sources...
Identification of a lysosomal pathway regulating degradation of the bone morphogenetic protein receptor type II.
Hannah J Durrington, Paul D Upton, Simon Hoer, Jessica Boname, Benjamin J Dunmore, Jun Yang, Trina K Crilley, Lynn M Butler, David J Blackbourn, Gerard B Nash, Paul J Lehner, Nicholas W Morrell
Aug 28, 2020
Bone morphogenetic proteins (BMPs) are critically involved in early development and cell differentiation. In humans, dysfunction of the bone morphogenetic protein type II receptor (BMPR-II) is associated with pulmonary arterial...
Effects of the cucumber mosaic virus 2a protein on aphid-plant interactions in Arabidopsis thaliana.
The cucumber mosaic virus (CMV) 2a RNA-dependent RNA polymerase protein has an additional function in Arabidopsis thaliana, which is to stimulate feeding deterrence (antixenosis) against aphids. Antixenosis is thought to...
Improving experimental phases for strong reflections prior to density modification.
Experimental phasing of diffraction data from macromolecular crystals involves deriving phase probability distributions. These distributions are often bimodal, making their weighted average, the centroid phase, improbable, so...
The discovery of Halictivirus resolves the Sinaivirus phylogeny.
Diane Bigot, Anne Dalmon, Bronwen Roy, Chunsheng Hou, Michèle Germain, Manon Romary, Shuai Deng, Qingyun Diao, Lucy A Weinert, James M Cook, Elisabeth A Herniou, Philippe Gayral
Jan 26, 2018
By providing pollination services, bees are among the most important insects, both in ecological and economical terms. Combined next-generation and classical sequencing approaches were applied to discover and study new insect...
Inhibition of apoptosis and NF-κB activation by vaccinia protein N1 occur via distinct binding surfaces and make different contributions to virulence.
Carlos Maluquer de Motes, Samantha Cooray, Hongwei Ren, Gabriel MF Almeida, Kieran McGourty, Mohammad W Bahar, David I Stuart, Jonathan M Grimes, Stephen C Graham, Geoffrey L Smith
Aug 08, 2017
Vaccinia virus (VACV) protein N1 is an intracellular virulence factor and belongs to a family of VACV B-cell lymphoma (Bcl)-2-like proteins whose members inhibit apoptosis or activation of pro-inflammatory transcription factors...
Transcriptional and Translational Landscape of Equine Torovirus.
Hazel Stewart, Katherine Brown, Adam M Dinan, Nerea Irigoyen, Eric J Snijder, Andrew E Firth
Oct 10, 2018
The genus Torovirus (subfamily Torovirinae, family Coronaviridae, order Nidovirales) encompasses a range of species that infect domestic ungulates, including cattle, sheep, goats, pigs, and horses, causing an acute self-limiting...
A Virally Encoded DeSUMOylase Activity Is Required for Cytomegalovirus Reactivation from Latency.
Emma L Poole, Verity G Kew, Jonathan CH Lau, Matthew J Murray, Thomas Stamminger, John H Sinclair, Matthew B Reeves
Oct 10, 2018
A subset of viral genes is required for the long-term latent infection of hematopoietic cells by human cytomegalovirus (HCMV). Here, we show that a latency-associated gene product (LUNA) promotes the disruption of cellular PML...
High-Definition Analysis of Host Protein Stability during Human Cytomegalovirus Infection Reveals Antiviral Factors and Viral Evasion Mechanisms.
Katie Nightingale, Kai-Min Lin, Benjamin J Ravenhill, Colin Davies, Luis Nobre, Ceri A Fielding, Eva Ruckova, Alice Fletcher-Etherington, Lior Soday, Hester Nichols, Daniel Sugrue, Eddie CY Wang, Pablo Moreno, Yagnesh Umrania, Edward L Huttlin, Robin Antrobus, Andrew J Davison, Gavin WG Wilkinson, Richard J Stanton, Peter Tomasec, Michael P Weekes
Nov 05, 2018
host-pathogen interaction Immune Evasion innate immunity lysosome Proteasome protein degradation pulsed SILAC quantitative proteomics restriction factor tandem mass tag Cytomegalovirus Cytomegalovirus Infections DNA-Binding Proteins Humans Immune Evasion Protein Stability Proteins Proteomics Transcription Factors Viral Proteins
Human cytomegalovirus manipulation of latently infected cells.
Primary infection with human cytomegalovirus (HCMV) results in the establishment of a lifelong infection of the host which is aided by the ability of HCMV to undergo a latent infection. One site of HCMV latency in vivo is in...
Human Cytomegalovirus Interleukin 10 Homologs
Emma Poole, Tainan Cerqueira Neves, Martha Trindade Oliveira, John Sinclair, Maria Cristina Carlan da Silva
Jul 20, 2020
Human Cytomegalovirus (HCMV) can cause a variety of health disorders that can lead to death in immunocompromised individuals and neonates. The HCMV lifecycle comprises both a lytic (productive) and a latent (non-productive)...
The influenza virus RNA polymerase as an innate immune agonist and antagonist.
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