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Application of error-prone PCR to functionally probe the morbillivirus Haemagglutinin protein.
Giulia Gallo, Carina Conceicao, Christina Tsirigoti, Brian Willett, Stephen C Graham, Dalan Bailey
Mar 09, 2021
The enveloped morbilliviruses utilise conserved proteinaceous receptors to enter host cells: SLAMF1 or Nectin-4. Receptor binding is initiated by the viral attachment protein Haemagglutinin (H), with the viral Fusion protein (F)...
directed evolution epPCR morbillivirus peste des petits ruminants virus viral entry Viral evolution Animals Cell Adhesion Molecules Hemagglutinins Viral Host Microbial Interactions Membrane Fusion Peste-des-petits-ruminants virus Polymerase Chain Reaction Sheep Signaling Lymphocytic Activation Molecule Family Member 1 Viral Fusion Proteins
Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses.
Eddie CY Wang, Mariana Pjechova, Katie Nightingale, Virginia-Maria Vlahava, Mihil Patel, Eva Ruckova, Simone K Forbes, Luis Nobre, Robin Antrobus, Dawn Roberts, Ceri A Fielding, Sepehr Seirafian, James Davies, Isa Murrell, Betty Lau, Gavin S Wilkie, Nicolás M Suárez, Richard J Stanton, Borivoj Vojtesek, Andrew Davison, Paul J Lehner, Michael P Weekes, Gavin WG Wilkinson, Peter Tomasec
Jul 05, 2018
CD58 is an adhesion molecule that is known to play a critical role in costimulation of effector cells and is intrinsic to immune synapse structure. Herein, we describe a virally encoded gene that inhibits CD58 surface...
Relating structure to evolution in class II viral membrane fusion proteins.
Yorgo Modis
Sep 08, 2020
Enveloped viruses must fuse their lipid membrane to a cellular membrane to deliver the viral genome into the cytoplasm for replication. Viral envelope proteins catalyze this critical membrane fusion event. They fall into at...
A novel membrane fusion protein family in Flaviviridae?
Enveloped viruses must fuse their lipid membrane to a cellular membrane to deliver their genome into the cytoplasm for replication. Viral envelope proteins catalyze this critical membrane fusion event. They fall into three...
A bioactive phlebovirus-like envelope protein in a hookworm endogenous virus
Monique Merchant, carlos Perez Mata, yangci Liu, haomin Zhai, Anna Protasio, Yorgo Modis
Jun 11, 2022
Endogenous viral elements (EVEs), accounting for 15% of our genome, serve as a genetic reservoir from which new genes can emerge. Nematode EVEs are particularly diverse and informative of virus evolution. We identify Atlas virus...