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BACKGROUND: Metformin is commonly used to treat gestational diabetes mellitus. This study investigated the effect of maternal metformin intervention during obese glucose-intolerant pregnancy on the gonadal white adipose tissue...

Foetal programming Gestational diabetes Maternal obesity Metformin Sex differences White adipose tissue Adiposity Animals Animals Newborn Diabetes Gestational Female Male Metformin Mice Mice Inbred C57BL obesity Maternal Pregnancy prenatal exposure delayed effects Sex Factors

Obesity is a complex disorder where the genome interacts with diet and environmental factors to ultimately influence body mass, composition and shape. Numerous studies have investigated how bulk lipid metabolism of adipose...

DNA Methylation lipidomics Mass Spectrometry one-carbon metabolism phosphatidylcholine White adipose tissue Adipocytes Adipose Tissue Adipose Tissue White Animals Lipid Metabolism lipidomics Mice Mice Inbred C57BL obesity

Global rates of obesity continue to rise and are necessarily the consequence of a long-term imbalance between energy intake and energy expenditure. This is the result of an expansion of adipose tissue due to both the hypertrophy...

brown adipose tissue Browning Exercise White adipose tissue /dk/atira/pure/subjectarea/asjc/2700/2712 name=Endocrinology, Diabetes and Metabolism /dk/atira/pure/subjectarea/asjc/1300/1310 name=Endocrinology /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being

Global rates of obesity continue to rise and are necessarily the consequence of a long-term imbalance between energy intake and energy expenditure. This is the result of an expansion of adipose tissue due to both the hypertrophy...

brown adipose tissue Browning Exercise White adipose tissue /dk/atira/pure/subjectarea/asjc/2700/2712 name=Endocrinology, Diabetes and Metabolism /dk/atira/pure/subjectarea/asjc/1300/1310 name=Endocrinology /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being

OBJECTIVE: Fibroblast growth factor 21 (FGF21) has been shown to rapidly lower body weight in the Siberian hamster, a preclinical model of adiposity. This induced negative energy balance mediated by FGF21 is associated with both...

brown adipose tissue FGF21 Glucose uptake Lipid uptake White adipose tissue β-Klotho Adipose Tissue Animals Cricetinae Energy Metabolism Fibroblast Growth Factors Male Phodopus Positron Emission Tomography Computed Tomography

Background

Metformin is commonly used to treat gestational diabetes mellitus. This study investigated the effect of maternal metformin intervention during obese glucose-intolerant pregnancy on the gonadal white adipose...

Metformin Sex differences Gestational diabetes White adipose tissue Maternal obesity Foetal programming

Highlights•FGF21 increases glucose and lipid uptake in adipose tissue.•The selective FGF21-induced increase in lipid uptake in BAT may fuel thermogenesis.•Unlike BAT, glucose uptake in WAT may be used for lipogenesis.

brown adipose tissue Glucose uptake White adipose tissue FGF21 Lipid uptake β-Klotho

Background: Metformin is commonly used to treat gestational diabetes mellitus. This study investigated the effect of maternal metformin intervention during obese glucose-intolerant pregnancy on the gonadal white adipose tissue...

Gestational diabetes Foetal programming Metformin Maternal obesity White adipose tissue Sex differences

developmental programming Fatty Liver Gestational diabetes Inflammation Maternal obesity Metformin White adipose tissue Humans Pregnancy Animals Mice Child Male Female Adult Infant Metformin Glucose Diabetes mellitus Type 2 Mice Inbred C57BL obesity Body composition Diabetes Gestational Fatty Liver Inflammation Lipids prenatal exposure delayed effects Diet High-Fat