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Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration.
Heather L Smith, Oliver J Freeman, Adrian J Butcher, Staffan Holmqvist, Ibrahim Humoud, Tobias Schätzl, Daniel T Hughes, Nicholas C Verity, Dean P Swinden, Joseph Hayes, Lis de Weerd, David H Rowitch, Robin Jm Franklin, Giovanna R Mallucci
Nov 28, 2019
Recent interest in astrocyte activation states has raised the fundamental question of how these cells, normally essential for synapse and neuronal maintenance, become pathogenic. Here, we show that activation of the unfolded...
LCN2 PERK signalling astrocyte reactivity state Astrocytes neurodegeneration Neuroprotection secretome synapse translational neuroscience Unfolded Protein Response Animals Astrocytes Endoplasmic reticulum stress Enzyme Inhibitors Eukaryotic Initiation Factor-2B In Vitro Techniques Memory Mice Neurodegenerative Diseases Phosphorylation Prion Diseases Protein Biosynthesis Protein Phosphatase 1 Signal Transduction Synapses Thapsigargin Transcriptome Tunicamycin Unfolded Protein Response eIF-2 Kinase