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Evolutionary plasticity in the allosteric regulator-binding site of pyruvate kinase isoform PykA from Pseudomonas aeruginosa.
Yassmin Abdelhamid, Paul Brear, Jack Greenhalgh, Xavier Chee, Taufiq Rahman, Martin Welch
Aug 29, 2019
Entner-Doudoroff Pathway Pseudomonas Pseudomonas aeruginosa PykA X-ray crystallography allostery bacterial metabolism Glycolysis pentose phosphate pathway (PPP) Pyruvate Kinase Allosteric Regulation Allosteric Site Bacterial Proteins Catalytic Domain Glucose-6-Phosphate Isoenzymes Models Molecular pentose phosphate pathway Pseudomonas aeruginosa Pyruvate Kinase
Gluconeogenic precursor availability regulates flux through the glyoxylate shunt in Pseudomonas aeruginosa.
The glyoxylate shunt bypasses the oxidative decarboxylation steps of the tricarboxylic acid (TCA) cycle, thereby conserving carbon skeletons for gluconeogenesis and biomass production. In Escherichia coli, carbon flux is...
Pseudomonas aeruginosa acetyl coenzyme A (acetyl-CoA) Allosteric Regulation bacterial metabolism bacterial pathogenesis bacterial virulence enzyme regulation enzyme structure Gluconeogenesis glyoxylate shunt Isocitrate Dehydrogenase isocitrate lyase metabolic adaptation metabolic regulation post-translational modification (PTM) tricarboxylic acid cycle (TCA cycle) (Krebs cycle) Acetyl Coenzyme A Citric Acid Cycle Crystallography X-Ray Decarboxylation Escherichia coli Gluconeogenesis Glyoxylates Isocitrate Dehydrogenase Isocitrate Lyase Kinetics Oxaloacetic Acid Phosphorylation Pseudomonas aeruginosa
Structure, Function and Regulation of a Second Pyruvate Kinase Isozyme in Pseudomonas aeruginosa.
Yassmin Abdelhamid, Meng Wang, Susannah L Parkhill, Paul Brear, Xavier Chee, Taufiq Rahman, Martin Welch
Jan 28, 2022
Pseudomonas aeruginosa (PA) depends on the Entner-Doudoroff pathway (EDP) for glycolysis. The main enzymatic regulator in the lower half of the EDP is pyruvate kinase. PA contains genes that encode two isoforms of pyruvate...
Structure, Function and Regulation of a Second Pyruvate Kinase Isozyme in Pseudomonas aeruginosa.
Yassmin Abdelhamid, Meng Wang, Susannah L Parkhill, Paul Brear, Xavier Chee, Md Taufiq Rahman, Martin Welch
Dec 15, 2021
Pseudomonas aeruginosa (PA) depends on the Entner-Doudoroff pathway (EDP) for glycolysis. The main enzymatic regulator in the lower half of the EDP is pyruvate kinase. PA contains genes that encode two isoforms of pyruvate...
Enterohemorrhagic Escherichia coli responds to gut microbiota metabolites by altering metabolism and activating stress responses.
Stefanie L Vogt, Antonio Serapio-Palacios, Sarah E Woodward, Andrew S Santos, Stefan PW de Vries, Michelle C Daigneault, Lisa V Brandmeier, Andrew J Grant, Duncan J Maskell, Emma Allen-Vercoe, B Brett Finlay
Apr 17, 2023
Enterohemorrhagic Escherichia coli (EHEC) is a major cause of severe bloody diarrhea, with potentially lethal complications, such as hemolytic uremic syndrome. In humans, EHEC colonizes the colon, which is also home to a diverse...