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Regulation of body temperature critically depends on thyroid hormone (TH). Recent studies revealed that TH induces browning of white adipose tissue, possibly contributing to the observed hyperthermia in hyperthyroid patients and...

beige adipose tissue beta3-adrenergic receptor Body Temperature brown adipose tissue glucose tolerance hyperthermia metabolism Norepinephrine pyrexia sympathetic nervous system thyroid hormone receptor Uncoupling Protein 1 Adipose Tissue Beige Adipose Tissue Brown Adipose Tissue White Animals Glucose Male Mice Mice Inbred C57BL Muscle Skeletal Receptors Adrenergic beta-3 Thermogenesis Thyroid Hormones Uncoupling Protein 1

Global rates of obesity continue to rise and are necessarily the consequence of a long-term imbalance between energy intake and energy expenditure. This is the result of an expansion of adipose tissue due to both the hypertrophy...

brown adipose tissue Browning Exercise White adipose tissue /dk/atira/pure/subjectarea/asjc/2700/2712 name=Endocrinology, Diabetes and Metabolism /dk/atira/pure/subjectarea/asjc/1300/1310 name=Endocrinology /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being

The incidence of overweight and obesity has reached epidemic proportions, making the control of body weight and its complications a primary health problem. Diet has long played a first-line role in preventing and managing...

brown adipose tissue dietary (poly)phenols energy expenditure Flavan-3-ols obesity resveratrol uncoupled protein 1 Adipose Tissue Brown Adrenergic Agonists Animals Anti-Obesity Agents Body Weight Diet Disease Models Animal Energy Metabolism Flavonoids Humans obesity Polyphenols resveratrol Stilbenes Tea Thermogenesis Uncoupling Protein 1

Elovl6 adaptive thermogenesis brown adipose tissue elongase energy expenditure fatty acid acyl chain length Acetyltransferases Adipose Tissue Brown Animals Blotting Western Fatty Acid Elongases Fatty Acids Mice Mice Inbred C57BL Mice Knockout Mitochondrial Proteins Real-Time Polymerase Chain Reaction Thermogenesis

OBJECTIVE: Fibroblast growth factor 21 (FGF21) has been shown to rapidly lower body weight in the Siberian hamster, a preclinical model of adiposity. This induced negative energy balance mediated by FGF21 is associated with both...

brown adipose tissue FGF21 Glucose uptake Lipid uptake White adipose tissue β-Klotho Adipose Tissue Animals Cricetinae Energy Metabolism Fibroblast Growth Factors Male Phodopus Positron Emission Tomography Computed Tomography

Global rates of obesity continue to rise and are necessarily the consequence of a long-term imbalance between energy intake and energy expenditure. This is the result of an expansion of adipose tissue due to both the hypertrophy...

brown adipose tissue Browning Exercise White adipose tissue /dk/atira/pure/subjectarea/asjc/2700/2712 name=Endocrinology, Diabetes and Metabolism /dk/atira/pure/subjectarea/asjc/1300/1310 name=Endocrinology /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being

Oxidation of cysteine thiols by physiological reactive oxygen species (ROS) initiates thermogenesis in brown and beige adipose tissues. Cellular selenocysteines, where sulfur is replaced with selenium, exhibit enhanced...

ROS brown adipose tissue Cysteine Selenocysteine Adipose Tissue Animals Cells Cultured Cysteine Male Mass Spectrometry Mice Mice Inbred C57BL obesity Reactive Oxygen Species selenium Thermogenesis Uncoupling Protein 1

Highlights•FGF21 increases glucose and lipid uptake in adipose tissue.•The selective FGF21-induced increase in lipid uptake in BAT may fuel thermogenesis.•Unlike BAT, glucose uptake in WAT may be used for lipogenesis.

brown adipose tissue Glucose uptake White adipose tissue FGF21 Lipid uptake β-Klotho

Sirtuin 3 (SIRT3) is one of the seven mammalian sirtuin homologs of the yeast Sir2 gene that has emerged as an important player in the regulation of energy metabolism in peripheral tissues. However, its role in the hypothalamus...

Adiposity Browning Energy balance Hypothalamus Sirtuins brown adipose tissue Adipose Tissue Brown Animals Diet High-Fat Energy Metabolism Female Male Mice Neurons Pro-Opiomelanocortin Sirtuin 3

OBJECTIVE: Obesity is one of the primary healthcare challenges of the 21st century. Signals relaying information regarding energy needs are integrated within the brain to influence body weight. Central among these integration...

5-HT2C receptor brown adipose tissue energy expenditure Hyperinsulinemia Hypothalamus obesity Pro-opiomelanocortin (POMC) Sexual dimorphism

Therapeutic activation of thermogenic brown adipose tissue (BAT) may be feasible to prevent, or treat, cardiometabolic disease. However, rodents are commonly housed below thermoneutrality (~20 °C) which can modulate their...

brown adipose tissue healthy expansion of adipose tissue Proteomics thermoneutrality Acetanilides Adipose Tissue Brown Animals Cold Temperature Disease Models Animal Gene Expression Profiling Gene Expression Regulation Male Proteomics Rats Subcutaneous Fat Thermogenesis Thiazoles Uncoupling Protein 1 Weight Gain