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Results: 25
Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I.
Zoe A Stephenson, Robert F Harvey, Kenneth R Pryde, Sarah Mistry, Rachel E Hardy, Riccardo Serreli, Injae Chung, Timothy EH Allen, Mark Stoneley, Marion MacFarlane, Peter M Fischer, Judy Hirst, Barrie Kellam, Anne E Willis
Jun 04, 2020
Biochemistry cancer biology cardiac liability chemical biology human Mitochondria toxicophore Adenosine Triphosphate Antineoplastic Agents Cell Death Cell Line Cell Proliferation Electron Transport Complex I Gene Expression Regulation Humans Mitochondria Mitochondria Heart Myocytes Cardiac Oxazoles Oxidative Phosphorylation Protein Binding Receptor ErbB-2 Triazoles
Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation
Tim DD Somerville, Giulia Biffi, Juliane Daßler-Plenker, Stella K Hur, Xue-Yan He, Krysten E Vance, Koji Miyabayashi, Yali Xu, Diogo Maia-Silva, Olaf Klingbeil, Osama E Demerdash, Jonathan B Preall, Michael A Hollingsworth, Mikala Egeblad, David A Tuveson, Christopher R Vakoc
May 05, 2020
Cytotoxic T-cells mediate exercise-induced reductions in tumor growth
Helene Rundqvist, Pedro Veliça, Laura Barbieri, Paulo A Gameiro, David Bargiela, Milos Gojkovic, Sara Mijwel, Stefan Markus Reitzner, David Wulliman, Emil Ahlstedt, Jernej Ule, Arne Östman, Randall S Johnson
Oct 24, 2020
EphrinB2 drives perivascular invasion and proliferation of glioblastoma stem-like cells
B Krusche, C Ottone, MP Clements, E Johnstone, K Goetsch, L Huang, SG Mota, K Khadayate, A Ashraf, T Davies, V De Paola, P Singh, F Roncaroli, SM Pollard, JL Martinez-Torrecuadrada, P Bertone, S Parrinello
Sep 27, 2017
The newly-arisen Devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer.
Alison Caldwell, Rachel Coleby, Cesar Tovar, Maximilian R Stammnitz, Young Mi Kwon, Rachel S Owen, Marios Tringides, Elizabeth P Murchison, Karsten Skjødt, Gareth J Thomas, Jim Kaufman, Tim Elliott, Gregory M Woods, Hannah VT Siddle
Nov 21, 2018
Devil Facial Tumour 2 (DFT2) is a recently discovered contagious cancer circulating in the Tasmanian devil (Sarcophilus harrisii), a species which already harbours a more widespread contagious cancer, Devil Facial Tumour 1...
Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma.
Floris Foijer, Lee A Albacker, Bjorn Bakker, Diana C Spierings, Ying Yue, Stephanie Z Xie, Stephanie Davis, Annegret Lutum-Jehle, Darin Takemoto, Brian Hare, Brinley Furey, Roderick T Bronson, Peter M Lansdorp, Allan Bradley, Peter K Sorger
Oct 14, 2020
Chromosome instability (CIN) is deleterious to normal cells because of the burden of aneuploidy. However, most human solid tumors have an abnormal karyotype implying that gain and loss of chromosomes by cancer cells confers a...
Mad2 Aneuploidy cancer biology chromosomal instability Chromosomes Genes human karyotype heterogeneity MOUSE spindle checkpoint Animals Carcinoma Hepatocellular Cell Survival chromosomal instability Disease Models Animal Hepatocytes Lymphoma T-Cell M Phase Cell Cycle Checkpoints Mad2 Proteins Mice Sequence Deletion T-Lymphocytes
Mitosis can drive cell cannibalism through entosis.
Joanne Durgan, Yun-Yu Tseng, Jens C Hamann, Marie-Charlotte Domart, Lucy Collinson, Alan Hall, Michael Overholtzer, Oliver Florey
Jun 25, 2019
Entosis is a form of epithelial cell cannibalism that is prevalent in human cancer, typically triggered by loss of matrix adhesion. Here, we report an alternative mechanism for entosis in human epithelial cells, driven by...
Loss of Kat2a enhances transcriptional noise and depletes acute myeloid leukemia stem-like cells.
Ana Filipa Domingues, Rashmi Kulkarni, George Giotopoulos, Shikha Gupta, Laura Vinnenberg, Liliana Arede, Elena Foerner, Mitra Khalili, Rita Romano Adao, Ayona Johns, Shengjiang Tan, Keti Zeka, Brian J Huntly, Sudhakaran Prabakaran, Cristina Pina
Mar 24, 2020
Acute Myeloid Leukemia (AML) is an aggressive hematological malignancy with abnormal progenitor self-renewal and defective white blood cell differentiation. Its pathogenesis comprises subversion of transcriptional regulation...
KAT2A single-cell RNA seq acute myeloid leukaemia cancer biology Chromosomes epigenetics Gene Expression MOUSE transcriptional bursting transcriptional heterogeneity Animals Chromatin Histone Acetyltransferases Humans Leukemia Myeloid Acute Mice Mice Knockout Neoplastic Stem Cells Single-Cell Analysis Transcription Genetic Transcriptome
Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer.
Andrea Strakova, Máire Ní Leathlobhair, Guo-Dong Wang, Ting-Ting Yin, Ilona Airikkala-Otter, Janice L Allen, Karen M Allum, Leontine Bansse-Issa, Jocelyn L Bisson, Artemio Castillo Domracheva, Karina F de Castro, Anne M Corrigan, Hugh R Cran, Jane T Crawford, Stephen M Cutter, Laura Delgadillo Keenan, Edward M Donelan, Ibikunle A Faramade, Erika Flores Reynoso, Eleni Fotopoulou, Skye N Fruean, Fanny Gallardo-Arrieta, Olga Glebova, Rodrigo F Häfelin Manrique, Joaquim Jgp Henriques, Natalia Ignatenko, Debbie Koenig, Marta Lanza-Perea, Remo Lobetti, Adriana M Lopez Quintana, Thibault Losfelt, Gabriele Marino, Inigo Martincorena, Simón Martínez Castañeda, Mayra F Martínez-López, Michael Meyer, Berna Nakanwagi, Andrigo B De Nardi, Winifred Neunzig, Sally J Nixon, Marsden M Onsare, Antonio Ortega-Pacheco, Maria C Peleteiro, Ruth J Pye, John F Reece, Jose Rojas Gutierrez, Haleema Sadia, Sheila K Schmeling, Olga Shamanova, Richard K Ssuna, Audrey E Steenland-Smit, Alla Svitich, Ismail Thoya Ngoka, Bogdan A Vițălaru, Anna P de Vos, Johan P de Vos, Oliver Walkinton, David C Wedge, Alvaro S Wehrle-Martinez, Mirjam G van der Wel, Sophie Ae Widdowson, Elizabeth P Murchison
Apr 26, 2016
Investigating the Phenotypic Effects of RING1- and YY1-Binding Protein (RYBP) in Glioblastoma Multiforme
Ronald W. Bucher
Jan 01, 0001
Glioblastoma multiforme (GBM) is an aggressive form of brain cancer that has horrendous survival outcomes with the use of current therapies. Further study into its molecular mechanisms will inform development of new, more...
RING1- and YY1-Binding Protein (RYBP) tumor suppressor glioblastoma multiforme Cancer Cell Invasion Cancer Cell Migration Epithelial-to-Mesenchymal Transition cancer biology
Published by: Winthrop University
Clonal transcriptomics identifies mechanisms of chemoresistance and empowers rational design of combination therapies.
Sophia A Wild, Ian G Cannell, Ashley Nicholls, Katarzyna Kania, Dario Bressan, CRUK IMAXT Grand Challenge Team, Gregory J Hannon, Kirsty Sawicka
Jan 22, 2023
Tumour heterogeneity is thought to be a major barrier to successful cancer treatment due to the presence of drug resistant clonal lineages. However, identifying the characteristics of such lineages that underpin resistance to...
Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I
Zoe A Stephenson, Robert F Harvey, Kenneth R Pryde, Sarah Mistry, Rachel E Hardy, Riccardo Serreli, Injae Chung, Timothy EH Allen, Mark Stoneley, Marion MacFarlane, Peter M Fischer, Judy Hirst, Barrie Kellam, Anne E Willis
Jun 26, 2020
Disruption of mitochondrial function selectively targets tumour cells that are dependent on oxidative phosphorylation. However, due to their high energy demands, cardiac cells are disproportionately targeted by mitochondrial...
Clonal transcriptomics identifies mechanisms of chemoresistance and empowers rational design of combination therapies.
Sophia A Wild, Ian G Cannell, Ashley Nicholls, Katarzyna Kania, Dario Bressan, CRUK IMAXT Grand Challenge Team, Gregory J Hannon, Kirsty Sawicka
Dec 16, 2022
Regulation of normal B-cell differentiation and malignant B-cell survival by OCT2.
Daniel J Hodson, Arthur L Shaffer, Wenming Xiao, George W Wright, Roland Schmitz, James D Phelan, Yandan Yang, Daniel E Webster, Lixin Rui, Holger Kohlhammer, Masao Nakagawa, Thomas A Waldmann, Louis M Staudt
Mar 01, 2016
Loss of Kat2a enhances transcriptional noise and depletes acute myeloid leukemia stem-like cells
Ana Filipa Domingues, Rashmi Kulkarni, George Giotopoulos, Shikha Gupta, Laura Vinnenberg, Liliana Arede, Elena Foerner, Mitra Khalili, Rita Romano Adao, Ayona Johns, Shengjiang Tan, Keti Zeka, Brian J Huntly, Sudhakaran Prabakaran, Cristina Pina
Feb 24, 2020
Cytotoxic T-cells mediate an exercise-induced reduction in tumor growth
Randall Johnson, Helene Rundqvist, Pedro Velica, Laura Barbieri, Paulo Gameiro, David Bargiela, Milos Gojkovic, Sara Mijwel, Stefan Reitzner, David Wulliman, Emil Ahlstedt, Jernej Ule, Arne Östman
Oct 20, 2020
An epigenetic switch regulates the ontogeny of AXL-positive/EGFR-TKi-resistant cells by modulating miR-335 expression.
Polona Safaric Tepes, Debjani Pal, Trine Lindsted, Ingrid Ibarra, Amaia Lujambio, Vilma Jimenez Sabinina, Serif Senturk, Madison Miller, Navya Korimerla, Jiahao Huang, Lawrence Glassman, Paul Lee, David Zeltsman, Kevin Hyman, Michael Esposito, Gregory J Hannon, Raffaella Sordella
Aug 13, 2021
Despite current advancements in research and therapeutics, lung cancer remains the leading cause of cancer-related mortality worldwide. This is mainly due to the resistance that patients develop against chemotherapeutic agents...
Published by: eLife
Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K.
John RP Knight, Nikola Vlahov, David M Gay, Rachel A Ridgway, William James Faller, Christopher Proud, Giovanna R Mallucci, Tobias von der Haar, Christopher Mark Smales, Anne E Willis, Owen J Sansom
Jan 28, 2022
Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation.
Tim DD Somerville, Giulia Biffi, Juliane Daßler-Plenker, Stella K Hur, Xue-Yan He, Krysten E Vance, Koji Miyabayashi, Yali Xu, Diogo Maia-Silva, Olaf Klingbeil, Osama E Demerdash, Jonathan B Preall, Michael A Hollingsworth, Mikala Egeblad, David A Tuveson, Christopher R Vakoc
Nov 16, 2020
A highly aggressive subset of pancreatic ductal adenocarcinomas undergo trans-differentiation into the squamous lineage during disease progression. Here, we investigated whether squamous trans-differentiation of human and mouse...
TP63 cancer biology Cancer-Associated Fibroblasts human human biology Inflammation Medicine MOUSE pancreatic cancer Squamous trans-differentiation Animals Cancer-Associated Fibroblasts Carcinoma Pancreatic Ductal Cell Lineage Cell Transdifferentiation Cytokines Humans Inflammation Membrane Proteins Mice Mice Inbred C57BL Neutrophil Infiltration Pancreatic Neoplasms Stromal Cells Tumor Microenvironment
Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma
Allison N Lau, Zhaoqi Li, Laura V Danai, Anna M Westermark, Alicia M Darnell, Raphael Ferreira, Vasilena Gocheva, Sharanya Sivanand, Evan C Lien, Kiera M Sapp, Jared R Mayers, Giulia Biffi, Christopher R Chin, Shawn M Davidson, David A Tuveson, Tyler Jacks, Nicholas J Matheson, Omer Yilmaz, Matthew G Vander Heiden
Aug 06, 2020
An epigenetic switch regulates the ontogeny of AXL-positive/EGFR-TKi-resistant cells by modulating miR-335 expression
Polona Safaric Tepes, Debjani Pal, Trine Lindsted, Ingrid Ibarra, Amaia Lujambio, Vilma Jimenez Sabinina, Serif Senturk, Madison Miller, Navya Korimerla, Jiahao Huang, Lawrence Glassman, Paul Lee, David Zeltsman, Kevin Hyman, Michael Esposito, Gregory J Hannon, Raffaella Sordella
Jul 28, 2021
Despite current advancements in research and therapeutics, lung cancer remains the leading cause of cancer-related mortality worldwide. This is mainly due to the resistance that patients develop against chemotherapeutic agents...
Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K.
John RP Knight, Nikola Vlahov, David M Gay, Rachel A Ridgway, William James Faller, Christopher Proud, Giovanna Mallucci, Tobias von der Haar, Christopher Mark Smales, Anne Willis, Owen J Sansom
Jan 04, 2022
Dissecting cell-type-specific metabolism in pancreatic ductal adenocarcinoma.
Allison N Lau, Zhaoqi Li, Laura V Danai, Anna M Westermark, Alicia M Darnell, Raphael Ferreira, Vasilena Gocheva, Sharanya Sivanand, Evan C Lien, Kiera M Sapp, Jared R Mayers, Giulia Biffi, Christopher R Chin, Shawn M Davidson, David A Tuveson, Tyler Jacks, Nicholas J Matheson, Omer Yilmaz, Matthew G Vander Heiden
Oct 02, 2020
Tumors are composed of many different cell types including cancer cells, fibroblasts, and immune cells. Dissecting functional metabolic differences between cell types within a mixed population can be challenging due to the rapid...
Global transcriptional analysis identifies a novel role for SOX4 in tumor-induced angiogenesis.
Stephin J Vervoort, Olivier G de Jong, M Guy Roukens, Cynthia L Frederiks, Jeroen F Vermeulen, Ana Rita Lourenço, Laura Bella, Ana Tufegdzic Vidakovic, José L Sandoval, Cathy Moelans, Miranda van Amersfoort, Margaret J Dallman, Alejandra Bruna, Carlos Caldas, Edward Nieuwenhuis, Elsken van der Wall, Patrick Derksen, Paul van Diest, Marianne C Verhaar, Eric W-F Lam, Michal Mokry, Paul J Coffer
Feb 04, 2019
The expression of the transcription factor SOX4 is increased in many human cancers, however, the pro-oncogenic capacity of SOX4 can vary greatly depending on the type of tumor. Both the contextual nature and the mechanisms...
An epigenetic switch regulates the ontogeny of AXL-positive/EGFR-TKi-resistant cells by modulating miR-335 expression.
Polona Safaric Tepes, Debjani Pal, Trine Lindsted, Ingrid Ibarra, Amaia Lujambio, Vilma Jimenez Sabinina, Serif Senturk, Madison Miller, Navya Korimerla, Jiahao Huang, Lawrence Glassman, Paul Lee, David Zeltsman, Kevin Hyman, Michael Esposito, Gregory J Hannon, Raffaella Sordella
Sep 05, 2021
Despite current advancements in research and therapeutics, lung cancer remains the leading cause of cancer-related mortality worldwide. This is mainly due to the resistance that patients develop against chemotherapeutic agents...
AXL cancer biology epigenetics erlotinib-resistant human Lung cancer Acrylamides Aniline Compounds Antineoplastic Agents Carcinoma Non-Small-Cell Lung Cell Line Tumor Drug Resistance Neoplasm Epigenesis Genetic ErbB Receptors Erlotinib Hydrochloride Humans Intercellular Signaling Peptides and Proteins Lung Neoplasms MicroRNAs Mutation Protein Kinase Inhibitors Proto-Oncogene Proteins RNA Messenger Receptor Protein-Tyrosine Kinases