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Hydrolysis of organic sulfate esters proceeds by two distinct mechanisms, water attacking at either sulfur (S-O bond cleavage) or carbon (C-O bond cleavage). In primary and secondary alkyl sulfates, attack at carbon is favored...

alkaline phosphatase superfamily arylsulfatase catalytic promiscuity oligomerization phosphatase Biocatalysis Catalytic Domain Esters Models Molecular Protein Multimerization Sinorhizobium meliloti Substrate Specificity Sulfatases

catalytic promiscuity fitness landscapes molecular evolution Mutagenesis phosphate transfer

Protease directed evolution nucleophilic catalysis adaptive protein evolution catalytic promiscuity PA clan Tobacco Etch Virus protease