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Cover Image for Alzheimer's disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss.

Alzheimer's disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss.

Alma S Popescu, Claire A Butler, David H Allendorf, Thomas M Piers, Anna Mallach, Julian Roewe, Peter Reinhardt, Alessandro Cinti, Loredana Redaelli, Christophe Boudesco, Laurent Pradier, Jennifer M Pocock, Peter Thornton, Guy C Brown

Dec 08, 2022

Alzheimer's Disease R47H variant TREM2 cystatin F iPSC-derived microglia phosphatidylserine Synapses Animals Humans Mice Alzheimer Disease Cystatins Membrane Glycoproteins Microglia Neurons Phagocytosis Phosphatidylserines Receptors Immunologic Synaptosomes

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