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AMPK-activated ULK1 phosphorylates PIKFYVE to drive formation of PtdIns5P-containing autophagosomes during glucose starvation.
AMPK Autophagy PIKfyve Ptdins5P ULK1 glucose starvation AMP-Activated Protein Kinase Kinases Animals Autophagosomes Autophagy-Related Protein-1 Homolog Glucose Humans Intracellular Signaling Peptides and Proteins Phosphatidylinositol 3-Kinases Phosphatidylinositol Phosphates Phosphorylation Signal Transduction
Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner.
AMPK PI(5)P PIKfyve ULK1 Autophagy glucose starvation mTOR phagophore AMP-Activated Protein Kinase Kinases Autophagosomes Autophagy Autophagy-Related Protein-1 Homolog Cell Line Gene Expression Regulation Glucose Humans metabolism Phosphatidylinositol 3-Kinases Phosphatidylinositol Phosphates Phospholipids Protein Kinases Signal Transduction