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Results: 303
Genome-wide Estrogen Receptor-α activation is sustained, not cyclical.
Estrogen Receptor-alpha (ER) drives 75% of breast cancers. Stimulation of the ER by estra-2-diol forms a transcriptionally-active chromatin-bound complex. Previous studies reported that ER binding follows a cyclical pattern....
Estrogen estrogen receptor MCF7 Breast Cancer Chromosomes Computational Biology endocrine Gene Expression human Systems Biology Base Sequence Binding Sites Estradiol Estrogen Receptor alpha Female Gene Expression Regulation Neoplastic Genome Human Genome-Wide Association Study Humans MCF-7 Cells Neoplasm Proteins Promoter Regions Genetic Protein Binding Receptors CXCR Signal Transduction Sorting Nexins Trefoil Factor-1
GABA, not BOLD, reveals dissociable learning-dependent plasticity mechanisms in the human brain.
Experience and training have been shown to facilitate our ability to extract and discriminate meaningful patterns from cluttered environments. Yet, the human brain mechanisms that mediate our ability to learn by suppressing...
brain plasticity Functional MRI human Magnetic Resonance Spectroscopy neuroscience visual learning Adult Female GABAergic Neurons Humans learning Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Neural Inhibition Neuronal Plasticity Occipital Lobe Perception Temporal Lobe Young Adult gamma-Aminobutyric Acid
Laser Capture and Deep Sequencing Reveals the Transcriptomic Programmes Regulating the Onset of Pancreas and Liver Differentiation in Human Embryos.
Rachel E Jennings, Andrew A Berry, David T Gerrard, Stephen J Wearne, James Strutt, Sarah Withey, Mariya Chhatriwala, Karen Piper Hanley, Ludovic Vallier, Nicoletta Bobola, Neil A Hanley
May 14, 2018
Feasibility of absolute quantification for 31 P MRS at 7 T.
³¹P MRS 7 T absolute quantification human Liver phosphorus magnetic resonance spectroscopy Adult Calibration Feasibility Studies Female Humans Image Processing Computer-Assisted Liver Magnetic Resonance Imaging Male Phantoms imaging Phosphorus Isotopes Signal Processing Computer-Assisted Young Adult
A prediction model of working memory across health and psychiatric disease using whole-brain functional connectivity.
Masahiro Yamashita, Yujiro Yoshihara, Ryuichiro Hashimoto, Noriaki Yahata, Naho Ichikawa, Yuki Sakai, Takashi Yamada, Noriko Matsukawa, Go Okada, Saori C Tanaka, Kiyoto Kasai, Nobumasa Kato, Yasumasa Okamoto, Ben Seymour, Hidehiko Takahashi, Mitsuo Kawato, Hiroshi Imamizu
Feb 25, 2019
Working memory deficits are present in many neuropsychiatric diseases with diagnosis-related severity. However, it is unknown whether this common behavioral abnormality is a continuum explained by a neural mechanism shared...
Biomarkers functional connectivity human neuroscience Prediction model rs-fMRI Working memory Brain Brain Mapping Female Humans Magnetic Resonance Imaging Male Memory Disorders Memory Short-Term Mental Disorders Models Neurological Nerve Net Neuropsychological Tests Prognosis Psychomotor Performance Young Adult
Case Report
The protein S-100B is a biomarker increasingly used within neurosurgery and neurointensive care. As a relatively sensitive, yet unspecific, indicator of CNS pathology, potential sources of error must be clearly understood when...
Characterizing a psychiatric symptom dimension related to deficits in goal-directed control.
Cardiac mitochondrial function depends on BUD23 mediated ribosome programming.
Matthew Baxter, Maria Voronkov, Toryn Poolman, Gina Galli, Christian Pinali, Laurence Goosey, Abigail Knight, Karolina Krakowiak, Robert Maidstone, Mudassar Iqbal, Min Zi, Sukhpal Prehar, Elizabeth J Cartwright, Julie Gibbs, Laura C Matthews, Antony D Adamson, Neil E Humphreys, Pedro Rebelo-Guiomar, Michal Minczuk, David A Bechtold, Andrew Loudon, David Ray
Mar 16, 2020
Efficient mitochondrial function is required in tissues with high energy demand such as the heart, and mitochondrial dysfunction is associated with cardiovascular disease. Expression of mitochondrial proteins is tightly...
Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination
Marisa Stebegg, Alexandre Bignon, Danika Lea Hill, Alyssa Silva-Cayetano, Christel Krueger, Ine Vanderleyden, Silvia Innocentin, Louis Boon, Jiong Wang, Martin S Zand, James Dooley, Jonathan Clark, Adrian Liston, Edward Carr, Michelle A Linterman
Mar 25, 2020
Germinal centres (GCs) are T follicular helper cell (Tfh)-dependent structures that form in response to vaccination, producing long-lived antibody secreting plasma cells and memory B cells that protect against subsequent...
Investigation of human trophoblast invasion in vitro.
Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions
Luis V Nobre, Katie Nightingale, Benjamin J Ravenhill, Robin Antrobus, Lior Soday, Jenna Nichols, James A Davies, Sepehr Seirafian, Eddie CY Wang, Andrew J Davison, Gavin WG Wilkinson, Richard J Stanton, Edward L Huttlin, Michael P Weekes
Jan 15, 2020
Human cytomegalovirus (HCMV) extensively modulates host cells, downregulating >900 human proteins during viral replication and degrading ≥133 proteins shortly after infection. The mechanism of degradation of most host proteins...
GC content shapes mRNA storage and decay in human cells.
Maïté Courel, Yves Clément, Clémentine Bossevain, Dominika Foretek, Olivia Vidal Cruchez, Zhou Yi, Marianne Bénard, Marie-Noëlle Benassy, Michel Kress, Caroline Vindry, Michèle Ernoult-Lange, Christophe Antoniewski, Antonin Morillon, Patrick Brest, Arnaud Hubstenberger, Hugues Roest Crollius, Nancy Standart, Dominique Weil
Jan 27, 2020
mRNA translation and decay appear often intimately linked although the rules of this interplay are poorly understood. In this study, we combined our recent P-body transcriptome with transcriptomes obtained following silencing of...
Comparative Genomics
Duncan T Odom
Jan 31, 2020
Using a common analysis pipeline to compare data from three major lineages of complex eukaryotes reveals that transcription seems to evolve at a common rate.
scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation.
E Madissoon, A Wilbrey-Clark, R J Miragaia, K Saeb-Parsy, K T Mahbubani, N Georgakopoulos, P Harding, K Polanski, N Huang, K Nowicki-Osuch, R C Fitzgerald, K W Loudon, J R Ferdinand, M R Clatworthy, A Tsingene, S van Dongen, M Dabrowska, M Patel, M J T Stubbington, S A Teichmann, O Stegle, K B Meyer
Feb 02, 2020
BACKGROUND:The Human Cell Atlas is a large international collaborative effort to map all cell types of the human body. Single-cell RNA sequencing can generate high-quality data for the delivery of such an atlas. However, delays...
Published by: Genome biology, volume 21, issue 1
Improved characterisation of MRSA transmission using within-host bacterial sequence diversity.
Matthew D Hall, Matthew TG Holden, Pramot Srisomang, Weera Mahavanakul, Vanaporn Wuthiekanun, Direk Limmathurotsakul, Kay Fountain, Julian Parkhill, Emma K Nickerson, Sharon J Peacock, Christophe Fraser
Nov 04, 2019
MRSA EPIDEMIOLOGY Global Health hospital infections human molecular epidemiology Adult Child Computational Biology Cross Infection DNA Bacterial Disease Outbreaks genetic variation Genome Bacterial Humans Methicillin-Resistant Staphylococcus aureus Phylogeny Polymorphism Single Nucleotide Staphylococcal Infections Thailand whole genome sequencing
Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 receptor via a common vestibule site.
Marijke Brams, Cedric Govaerts, Kumiko Kambara, Kerry L Price, Radovan Spurny, Anant Gharpure, Els Pardon, Genevieve L Evans, Daniel Bertrand, Sarah CR Lummis, Ryan E Hibbs, Jan Steyaert, Chris Ulens
Feb 28, 2020
Pentameric ligand-gated ion channels (pLGICs) or Cys-loop receptors are involved in fast synaptic signaling in the nervous system. Allosteric modulators bind to sites that are remote from the neurotransmitter binding site, but...
human neuroscience allosteric modulation structural biology Ligand-Gated Ion Channels molecular biophysics
Published by: eLife
Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 receptor via a common vestibule site.
Marijke Brams, Cedric Govaerts, Kumiko Kambara, Kerry L Price, Radovan Spurny, Anant Gharpure, Els Pardon, Genevieve L Evans, Daniel Bertrand, Sarah CR Lummis, Ryan E Hibbs, Jan Steyaert, Chris Ulens
Apr 17, 2020
Pentameric ligand-gated ion channels (pLGICs) or Cys-loop receptors are involved in fast synaptic signaling in the nervous system. Allosteric modulators bind to sites that are remote from the neurotransmitter binding site, but...
Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation
Tim DD Somerville, Giulia Biffi, Juliane Daßler-Plenker, Stella K Hur, Xue-Yan He, Krysten E Vance, Koji Miyabayashi, Yali Xu, Diogo Maia-Silva, Olaf Klingbeil, Osama E Demerdash, Jonathan B Preall, Michael A Hollingsworth, Mikala Egeblad, David A Tuveson, Christopher R Vakoc
May 05, 2020
Improving pandemic influenza risk assessment.
Colin A Russell, Peter M Kasson, Ruben O Donis, Steven Riley, John Dunbar, Andrew Rambaut, Jason Asher, Stephen Burke, C Todd Davis, Rebecca J Garten, Sandrasegaram Gnanakaran, Simon I Hay, Sander Herfst, Nicola S Lewis, James O Lloyd-Smith, Catherine A Macken, Sebastian Maurer-Stroh, Elizabeth Neuhaus, Colin R Parrish, Kim M Pepin, Samuel S Shepard, David L Smith, David L Suarez, Susan C Trock, Marc-Alain Widdowson, Dylan B George, Marc Lipsitch, Jesse D Bloom
Jun 03, 2015
Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I.
Zoe A Stephenson, Robert F Harvey, Kenneth R Pryde, Sarah Mistry, Rachel E Hardy, Riccardo Serreli, Injae Chung, Timothy EH Allen, Mark Stoneley, Marion MacFarlane, Peter M Fischer, Judy Hirst, Barrie Kellam, Anne E Willis
Jun 04, 2020
Biochemistry cancer biology cardiac liability chemical biology human Mitochondria toxicophore Adenosine Triphosphate Antineoplastic Agents Cell Death Cell Line Cell Proliferation Electron Transport Complex I Gene Expression Regulation Humans Mitochondria Mitochondria Heart Myocytes Cardiac Oxazoles Oxidative Phosphorylation Protein Binding Receptor ErbB-2 Triazoles
Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes.
Yohei Ohashi, Shirley Tremel, Glenn Robert Masson, Lauren McGinney, Jerome Boulanger, Ksenia Rostislavleva, Christopher M Johnson, Izabella Niewczas, Jonathan Clark, Roger L Williams
Jun 30, 2020
The lipid kinase VPS34 orchestrates diverse processes, including autophagy, endocytic sorting, phagocytosis, anabolic responses and cell division. VPS34 forms various complexes that help adapt it to specific pathways, with...
Wiskott Aldrich syndrome protein regulates non-selective autophagy and mitochondrial homeostasis in human myeloid cells.
Elizabeth Rivers, Rajeev Rai, Jonas Lötscher, Michael Hollinshead, Gasper Markelj, James Thaventhiran, Austen Worth, Alessia Cavazza, Christoph Hess, Mona Bajaj-Elliott, Adrian J Thrasher
Feb 01, 2021
The actin cytoskeletal regulator Wiskott Aldrich syndrome protein (WASp) has been implicated in maintenance of the autophagy-inflammasome axis in innate murine immune cells. Here, we show that WASp deficiency is associated with...
Environmentally sensitive hotspots in the methylome of the early human embryo.
Matt J Silver, Ayden Saffari, Noah J Kessler, Gririraj R Chandak, Caroline HD Fall, Prachand Issarapu, Akshay Dedaniya, Modupeh Betts, Sophie E Moore, Michael N Routledge, Zdenko Herceg, Cyrille Cuenin, Maria Derakhshan, Philip T James, David Monk, Andrew M Prentice
Mar 28, 2022
In humans, DNA methylation marks inherited from gametes are largely erased following fertilisation, prior to construction of the embryonic methylome. Exploiting a natural experiment of seasonal variation including changes in...
Impact of COVID-19-related disruptions to measles, meningococcal A, and yellow fever vaccination in 10 countries
Katy AM Gaythorpe, Kaja Abbas, John Huber, Andromachi Karachaliou, Niket Thakkar, Kim Woodruff, Xiang Li, Susy Echeverria-Londono, VIMC Working Group on COVID-19 Impact on Vaccine Preventable Disease, Matthew Ferrari, Michael L Jackson, Kevin McCarthy, T Alex Perkins, Caroline Trotter, Mark Jit, Andre Arsene, Felicity Cutts, Emily Dansereau, Antoine Durupt, Ulla Griffiths, Jennifer Horton, Kendall Krause, Katrina Kretsinger, Tewodaj Mengistu, Imran Mirza, Simon R Procter, Stephanie Shendale
Jul 28, 2021
Background:: Childhood immunisation services have been disrupted by the COVID-19 pandemic. WHO recommends considering outbreak risk using epidemiological criteria when deciding whether to conduct preventive vaccination campaigns...
TGFβ signalling is required to maintain pluripotency of human naïve pluripotent stem cells.
Anna Osnato, Stephanie Brown, Christel Krueger, Simon Andrews, Amanda J Collier, Shota Nakanoh, Mariana Quiroga Londoño, Brandon T Wesley, Daniele Muraro, A Sophie Brumm, Kathy K Niakan, Ludovic Vallier, Daniel Ortmann, Peter J Rugg-Gunn
Oct 01, 2021
Published by: eLife
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