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Microenvironmental modulation of the developing tumour
Successful establishment of a tumour relies on a cascade of interactions between cancer cells and stromal cells within an evolving microenvironment. Both immune and nonimmune cellular components are key factors in this process...
Deployable extrusion bioprinting of compartmental tumoroids with cancer associated fibroblasts for immune cell interactions.
Corrado Mazzaglia, Yaqi Sheng, Leonor Nunes Rodrigues, Iek Man Lei, Jacqueline D Shields, Yan Yan Shery Huang
Jan 31, 2023
Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth.
Sarah Davidson, Mirjana Efremova, Angela Riedel, Bidesh Mahata, Jhuma Pramanik, Jani Huuhtanen, Gozde Kar, Roser Vento-Tormo, Tzachi Hagai, Xi Chen, Muzlifah A Haniffa, Jacqueline D Shields, Sarah A Teichmann
May 01, 2020
Circulating interleukins in relation to coronary artery disease, atrial fibrillation and ischemic stroke and its subtypes
BACKGROUND: The causal role of interleukins (ILs) for cardiovascular disease has not been fully elucidated. We conducted a Mendelian randomization study to investigate the associations of circulating ILs with coronary artery...
Atrial fibrillation Coronary Artery Disease immune Interleukins ischemic stroke Mendelian Randomization Analysis Atrial fibrillation Brain Ischemia Coronary Artery Disease Genome-Wide Association Study Humans Interleukins ischemic stroke Mendelian Randomization Analysis Polymorphism Single Nucleotide Risk Factors stroke
Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells
L Chen, B Ge, FP Casale, L Vasquez, T Kwan, D Garrido-Martín, S Watt, Y Yan, K Kundu, S Ecker, A Datta, D Richardson, F Burden, D Mead, AL Mann, JM Fernandez, S Rowlston, SP Wilder, S Farrow, X Shao, JJ Lambourne, A Redensek, CA Albers, V Amstislavskiy, S Ashford, K Berentsen, L Bomba, G Bourque, D Bujold, S Busche, M Caron, S-H Chen, W Cheung, O Delaneau, ET Dermitzakis, H Elding, I Colgiu, FO Bagger, P Flicek, E Habibi, V Iotchkova, E Janssen-Megens, B Kim, H Lehrach, E Lowy, A Mandoli, F Matarese, MT Maurano, JA Morris, V Pancaldi, F Pourfarzad, K Rehnstrom, A Rendon, T Risch, N Sharifi, M-M Simon, M Sultan, A Valencia, K Walter, S-Y Wang, M Frontini, SE Antonarakis, L Clarke, M-L Yaspo, S Beck, R Guigo, D Rico, JHA Martens, WH Ouwehand, TW Kuijpers, DS Paul, HG Stunnenberg, O Stegle, K Downes, T Pastinen, N Soranzo
Dec 22, 2016