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Being in a loop
Chromatin architecture has a significant impact on gene expression. Evidence in the last two decades support RNA as an important component of chromatin structure [Genes Dev. (2005) 19, 1635–1655; PLoS ONE (2007) 2, e1182; Nat....
Antisense Activity across the Nesp Promoter is Required for Nespas-Mediated Silencing in the Imprinted Gnas Cluster.
Charlotte J Tibbit, Christine M Williamson, Stuti Mehta, Simon T Ball, Mita Chotalia, Wade T Nottingham, Sally A Eaton, Mohamed M Quwailid, Lydia Teboul, Gavin Kelsey, Jo Peters
Jun 24, 2019
Macro long non-coding RNAs (lncRNAs) play major roles in gene silencing in inprinted gene clusters. Within the imprinted Gnas cluster, the paternally expressed Nespas lncRNA downregulates its sense counterpart Nesp. To explore...
A Viral Long Non-Coding RNA Protects against Cell Death during Human Cytomegalovirus Infection of CD14+ Monocytes.
Apoptosis human cytomegalovirus latency long non-coding RNA Oxidative Stress Reactive Oxygen Species antioxidants Apoptosis Cells Cultured Cytomegalovirus Humans Lipopolysaccharide Receptors Mitochondria Monocytes Mutation Oxidative Stress RNA Long Noncoding RNA Viral Reactive Oxygen Species Virus Latency
A Viral Long Non-Coding RNA Protects against Cell Death during Human Cytomegalovirus Infection of CD14+ Monocytes
Long non-coding RNA β2.7 is the most highly transcribed viral gene during latent human cytomegalovirus (HCMV) infection. However, as yet, no function has ever been ascribed to β2.7 during HCMV latency. Here we show that...
Long Non-coding RNAs Are Central Regulators of the IL-1β-Induced Inflammatory Response in Normal and Idiopathic Pulmonary Lung Fibroblasts
Marina R. Hadjicharalambous, Benoît Roux, Carol A. Feghali-Bostwick, Lynne A. Murray, Deborah L. Clarke, Mark Lindsay
Dec 11, 2018
There is accumulating evidence to indicate that long non-coding RNAs (lncRNAs) are important regulators of the inflammatory response. In this report, we have employed next generation sequencing to identify 14 lncRNAs that are...
Being in a loop
Chromatin architecture has a significant impact on gene expression. Evidence in the last two decades support RNA as an important component of chromatin structure [Genes Dev. (2005) 19, 1635–1655; PLoS ONE (2007) 2, e1182; Nat....
A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation
Lin28a/Mirlet7 de novo DNA methylation developmental biology long non-coding RNA MOUSE Pluripotency stem cell transition Stem Cells Animals Cell Differentiation DNA (Cytosine-5-)-Methyltransferases DNA Methylation DNA Methyltransferase 3A Gene Deletion Gene Expression Regulation Mice MicroRNAs Mouse embryonic stem cells RNA Long Noncoding RNA-Binding Proteins
The Roles of H19 in Regulating Inflammation and Aging.
Bin Wang, Chun Wai Suen, Haibin Ma, Yan Wang, Ling Kong, Dajiang Qin, Yuk Wai Wayne Lee, Gang Li
Nov 10, 2020
Accumulating evidence suggests that long non-coding RNA H19 correlates with several aging processes. However, the role of H19 in aging remains unclear. Many studies have elucidated a close connection between H19 and inflammatory...
Identification of functional long non-coding RNAs in C. elegans.
Alper Akay, David Jordan, Isabela Cunha Navarro, Tomasz Wrzesinski, Chris P Ponting, Eric A Miska, Wilfried Haerty
May 09, 2019
BACKGROUND: Functional characterisation of the compact genome of the model organism Caenorhabditis elegans remains incomplete despite its sequencing 20 years ago. The last decade of research has seen a tremendous increase in the...
Divergent signalling pathways regulate lipopolysaccharide-induced eRNA expression in human monocytic THP1 cells
Recent studies have indicated that non-coding RNAs transcribed from enhancer regions are important regulators of enhancer function and gene expression. In this report, we have characterised the expression of six enhancer RNAs...
RATA
Long non-coding RNAs (lncRNAs) regulate critical cellular processes and their dysregulation contributes to multiple diseases. Although only a few lncRNAs have defined mechanisms, many of these characterized lncRNAs interact with...
Long Non-coding RNAs Are Central Regulators of the IL-1β-Induced Inflammatory Response in Normal and Idiopathic Pulmonary Lung Fibroblasts
Marina R. Hadjicharalambous, Benoît Roux, Carol A. Feghali-Bostwick, Lynne A. Murray, Deborah L. Clarke, Mark Lindsay
Dec 11, 2018
There is accumulating evidence to indicate that long non-coding RNAs (lncRNAs) are important regulators of the inflammatory response. In this report, we have employed next generation sequencing to identify 14 lncRNAs that are...
Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular Senescence.
Takayuki Nojima, Michael Tellier, Jonathan Foxwell, Claudia Ribeiro de Almeida, Sue Mei Tan-Wong, Somdutta Dhir, Gwendal Dujardin, Ashish Dhir, Shona Murphy, Nick J Proudfoot
Jun 24, 2019
Extensive tracts of the mammalian genome that lack protein-coding function are still transcribed into long noncoding RNA. While these lncRNAs are generally short lived, length restricted, and non-polyadenylated, how their...
DNA replication stress H3K36me3 R-loop SPT6 Cellular Senescence eRNA integrator complex long non-coding RNA mNET-seq mNuc-seq Animals Cell Proliferation Cellular Senescence Chromatin Assembly and Disassembly DNA Damage DNA Polymerase II DNA Replication DNA Neoplasm Drosophila melanogaster Female Gene Expression Regulation Neoplastic HeLa Cells Histones Humans Methylation Nucleic Acid Conformation Nucleic Acid Heteroduplexes RNA Stability RNA Long Noncoding RNA Messenger RNA Neoplasm Transcription Factors Transcription Genetic Uterine Neoplasms
Divergent signalling pathways regulate lipopolysaccharide-induced eRNA expression in human monocytic THP1 cells
Recent studies have indicated that non-coding RNAs transcribed from enhancer regions are important regulators of enhancer function and gene expression. In this report, we have characterised the expression of six enhancer RNAs...
Transposon-Derived Non-coding RNAs and Their Function in Plants.
Jungnam Cho
Sep 08, 2018
Transposable elements (TEs) are often regarded as harmful genomic factors and indeed they are strongly suppressed by the epigenetic silencing mechanisms. On the other hand, the mobilization of TEs brings about variability of...
Long Non-coding RNAs as Functional and Structural Chromatin Modulators in Acute Myeloid Leukemia.
Acute myeloid leukemia is a hematopoietic neoplasm of dismal prognosis that results from the accumulation of immature myeloid blasts in the bone marrow and the peripheral blood. It is strongly dependent on epigenetic regulation...