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This work describes synthetic methodology development in organic chemistry. The goal of this work is to demonstrate new ways of making biologically-relevant molecules that are in line with the principles of green chemistry...

nitroalkenes transfer hydrogenation catalytic Green chemistry Amines medicinal chemistry asymmetric synthesis Chemistry Environmental Chemistry Medicinal-Pharmaceutical Chemistry Organic chemistry Physical Sciences and Mathematics

This review presents a comprehensive overview on selected synthetic routes towards commercial drug compounds as published in both journal and patent literature. Owing to the vast number of potential structures, we have...

five-membered rings heterocycles medicinal chemistry Pharmaceuticals Synthesis

amine synthesis medicinal chemistry photoredox chemistry radical chemistry total synthesis

Biofilms Biosensors medicinal chemistry Nanotechnology wound biofilms Anti-Bacterial Agents Biofilms Humans Wound Healing Wound Infection

BioA EthR Cytochrome P450 fragment-based approaches medicinal chemistry pantothenate synthetase Tuberculosis Bacterial Proteins Cytochrome P-450 Enzyme System Drug Discovery Humans Mycobacterium tuberculosis Peptide Synthases Repressor Proteins Transaminases Tuberculosis

This review which is the second in this series summarises the most common synthetic routes as applied to the preparation of many modern pharmaceutical compounds categorised as containing a six-membered heterocyclic ring. The...

heterocycles medicinal chemistry Pharmaceuticals six-membered rings Synthesis

Several bacteria rely on the reductive sulphur assimilation pathway, absent in mammals, to synthesise cysteine. Reduction of virulence and decrease in antibiotic resistance have already been associated with mutations on the...

O-acetylserine sulphhydrylase Scaffold hopping fragments ligand-based drug design medicinal chemistry Pyrazoles Anti-Bacterial Agents Bacteria Binding Sites Biological Assay Computer Simulation Cysteine Synthase DNA Recombinant Drug Design Ligands Models Molecular Small Molecule Libraries Structure-Activity Relationship

PROTACs Drug Discovery Androgen receptor medicinal chemistry

compound collections Diversity-oriented synthesis Fragment-based drug discovery medicinal chemistry organic synthesis

Diversity-oriented synthesis Drug Discovery medicinal chemistry molecular diversity quaternary stereocenters