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Heterogeneity of Myc expression in breast cancer exposes pharmacological vulnerabilities revealed through executable mechanistic modeling.
Peter Kreuzaler, Matthew A Clarke, Elizabeth J Brown, Catherine H Wilson, Roderik M Kortlever, Nir Piterman, Trevor Littlewood, Gerard I Evan, Jasmin Fisher
Oct 14, 2019
Cells with higher levels of Myc proliferate more rapidly and supercompetitively eliminate neighboring cells. Nonetheless, tumor cells in aggressive breast cancers typically exhibit significant and stable heterogeneity in their...