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Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace.
Maren Heimhalt, Alex Berndt, Jane Wagstaff, Madhanagopal Anandapadamanaban, Olga Perisic, Sarah Maslen, Stephen McLaughlin, Conny Wing-Heng Yu, Glenn R Masson, Andreas Boland, Xiaodan Ni, Keitaro Yamashita, Garib N Murshudov, Mark Skehel, Stefan M Freund, Roger L Williams
Sep 14, 2021
The mTORC1 kinase complex regulates cell growth, proliferation, and survival. Because mis-regulation of DEPTOR, an endogenous mTORC1 inhibitor, is associated with some cancers, we reconstituted mTORC1 with DEPTOR to understand...
DEPTOR Biochemistry Cancer chemical biology cryo-EM human mTOR molecular biophysics partial inhibition Signal Transduction structural biology Binding Sites Cryoelectron Microscopy Escherichia coli Gene Expression Regulation Humans Image Processing Computer-Assisted Intracellular Signaling Peptides and Proteins Mechanistic Target of Rapamycin Complex 1 Models Molecular PDZ Domains Protein Binding Protein Conformation Recombinant Proteins TOR Serine-Threonine Kinases