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data-integration Drosophila melanogaster Mass Spectrometry protein complexes protein-protein interactions proteomics data mining

proteomics data mining protein-protein interactions protein complexes Mass Spectrometry data-integration Drosophila melanogaster

IDP biophysics coupled folding and binding Electrostatics Kinetics phi-value protein dynamic protein electrostatics Protein Folding protein-protein interactions residual structure signaling Apoptosis Regulatory Proteins CREB-Binding Protein Cyclic AMP Response Element-Binding Protein Humans Hydrophobic and Hydrophilic Interactions Intrinsically Disordered Proteins Kinetics Molecular Dynamics Simulation Myeloid Cell Leukemia Sequence 1 Protein Protein Binding Protein Folding Protein Interaction Domains and Motifs Proto-Oncogene Proteins Signal Transduction Static Electricity Thermodynamics

A major biochemical goal is the ability to mimic nature in engineering highly specific protein-protein interactions. We previously devised a computational interactome screen to identify eight peptides that form four...

protein-protein interactions coiled coils library screening Computational Biology interactome screen heterospecific proteins De novo design

Plk1 PLK4 PPI inhibitor Polo-box domain Polo-like kinase c-MET cancer therapy mutant Kras protein-protein interactions

BRCA2 RAD51 biophysics homologous recombination INHIBITORS protein-protein interactions Amino Acid Motifs BRCA2 Protein Binding Sites Drug Design Humans Molecular Dynamics Simulation Protein Binding Protein Structure Tertiary Pyrococcus furiosus Rad51 Recombinase Small Molecule Libraries Structure-Activity Relationship Thermodynamics

Proteins (thrombomodulin and complement component 3) were used from two important pathways (blood coagulation and innate immunity) in the human body to investigate how they bind and react in a modeled disease state of atypical...

Thrombomodulin complement component 3 atypical hemolytic-uremic syndrome protein-protein interactions Biochemistry, Biophysics, and Structural Biology Life Sciences

The Wnt signalling pathway plays an important role in cell proliferation, differentiation, and fate decisions in embryonic development and the maintenance of adult tissues. The twelve armadillo (ARM) repeat-containing protein...

repeat protein tandem-repeat protein intrinsic disorder Intrinsically Disordered Protein Fuzzy Complex protein-protein interactions Protein Folding Armadillo Repeat BETA-CATENIN Tcf

To date, most research into the inhibition of oncogenic transcriptional regulator, Activator Protein 1 (AP-1), has focused on heterodimers of cJun and cFos. However, the Fra1 homologue remains an important cancer target. Here we...

Coiled coil activator protein-1 fos related antigen-1 Transcription factor Computational design peptide libraries protein-protein interactions protein-fragment complementation assay /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being

The Wnt signalling pathway plays an important role in cell proliferation, differentiation, and fate decisions in embryonic development and the maintenance of adult tissues. The twelve armadillo (ARM) repeat-containing protein...

Protein Folding BETA-CATENIN Intrinsically Disordered Protein protein-protein interactions intrinsic disorder Tcf Armadillo Repeat Fuzzy Complex repeat protein tandem-repeat protein

Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are now recognised as major determinants in cellular regulation. This white paper presents a roadmap for future e-infrastructure developments...

ELIXIR cellular regulation community standards Databases Intrinsically Disordered Proteins protein dynamics protein function protein-protein interactions Intrinsically Disordered Proteins

The Wnt signalling pathway plays an important role in cell proliferation, differentiation, and fate decisions in embryonic development and the maintenance of adult tissues. The twelve armadillo (ARM) repeat-containing protein...

Tcf Armadillo Repeat BETA-CATENIN Fuzzy Complex intrinsic disorder Intrinsically Disordered Protein Protein Folding protein-protein interactions repeat protein tandem-repeat protein Crystallography X-Ray Humans Intrinsically Disordered Proteins Mutagenesis Site-Directed Protein Structure Quaternary Transcription Factor 7-Like 2 Protein beta Catenin

To date, most research into the inhibition of oncogenic transcriptional regulator, Activator Protein 1 (AP-1), has focused on heterodimers of cJun and cFos. However, the Fra1 homologue remains an important cancer target. Here we...

Coiled coil activator protein-1 fos related antigen-1 Transcription factor Computational design peptide libraries protein-protein interactions protein-fragment complementation assay /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being

Members of the DEAD-box family of RNA helicases contribute to virtually every aspect of RNA metabolism, in organisms from all domains of life. Many of these helicases are constituents of multicomponent assemblies, and their...

Analytical Ultracentrifugation protein-protein interactions RNA helicase RNA-binding protein Regulator of Ribonuclease Activity A RhlB RraA SrmB X-ray crystallography Crystallography X-Ray DEAD-box RNA Helicases Endoribonucleases Escherichia coli Escherichia coli Proteins Models Molecular Protein Binding Protein Structure Quaternary Protein Structure Tertiary

Cancer fragment-based ligand design nuclear transporters protein-protein interactions structure-guided ligand design Binding Sites Cell Cycle Proteins Humans Ligands Microtubule-Associated Proteins Models Molecular Molecular Structure Nuclear Proteins Protein Binding Small Molecule Libraries alpha Karyopherins

Pseudomonas aeruginosa RNA degradosome RNA metabolism bacteriophage Biochemistry infectious disease microbiology protein-protein interactions Virus Binding Sites Crystallography X-Ray Endoribonucleases host-parasite interactions Models Molecular Multienzyme Complexes Polyribonucleotide Nucleotidyltransferase Protein Binding Protein Conformation Protein Multimerization Pseudomonas Phages Pseudomonas aeruginosa RNA Helicases Viral Proteins

The exploitation of synthetic lethality by small-molecule targeting of pathways that maintain genomic stability is an attractive chemotherapeutic approach. The Ctf4/AND-1 protein hub, which links DNA replication, repair, and...

Ctf4 protein chemical biology chromosome stability protein-protein interactions stapled peptides Amino Acid Motifs Binding Sites Crystallography X-Ray DNA Polymerase I DNA-Binding Proteins Diazonium Compounds Fluorescence Polarization Genomic Instability Humans Molecular Dynamics Simulation Peptides Protein Interaction Domains and Motifs Protein Structure Tertiary Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins

Non-homologous end joining DNA Repair DNA-PKcs XRCC4 Artemis protein-protein interactions

A major biochemical goal is the ability to mimic nature in engineering highly specific protein-protein interactions. We previously devised a computational interactome screen to identify eight peptides that form four...

protein-protein interactions coiled coils library screening Computational Biology interactome screen heterospecific proteins De novo design