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Results: 11
Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo.
Lee M Booty, Justyna M Gawel, Filip Cvetko, Stuart T Caldwell, Andrew R Hall, John F Mulvey, Andrew M James, Elizabeth C Hinchy, Tracy A Prime, Sabine Arndt, Cristiane Beninca, Thomas P Bright, Menna R Clatworthy, John R Ferdinand, Hiran A Prag, Angela Logan, Julien Prudent, Thomas Krieg, Richard C Hartley, Michael P Murphy
May 15, 2019
Inhibition of Mitochondrial Redox Signaling with MitoQ Prevents Metastasis of Human Pancreatic Cancer in Mice.
Tania Capeloa, Justine A Van de Velde, Donatienne d'Hose, Sara G Lipari, Françoise Derouane, Loïc Hamelin, Marie Bedin, Thibaut Vazeille, François P Duhoux, Michael P Murphy, Paolo E Porporato, Bernard Gallez, Pierre Sonveaux
Nov 15, 2022
Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy.
Sukru Anil Dogan, Raffaele Cerutti, Cristiane Benincá, Gloria Brea-Calvo, Howard Trevor Jacobs, Massimo Zeviani, Marten Szibor, Carlo Viscomi
Sep 08, 2018
Alternative oxidases (AOXs) bypass respiratory complexes III and IV by transferring electrons from coenzyme Q directly to O2. They have therefore been proposed as a potential therapeutic tool for mitochondrial diseases. We...
ROS alternative oxidase antioxidant Autophagy mitochondrial biogenesis mitochondrial disease redox signaling satellite cells stress responses Animals Autophagy Female Male Mice Mice Inbred C57BL Mice Knockout Mitochondrial Myopathies Mitochondrial Proteins Muscle Skeletal Organelle Biogenesis Oxidation-Reduction Oxidoreductases Plant Proteins Reactive Oxygen Species Signal Transduction
Divergent trajectories of cellular bioenergetics, intermediary metabolism and systemic redox status in survivors and non-survivors of critical illness.
Helen T McKenna, Katie A O'Brien, Bernadette O Fernandez, Magdalena Minnion, Adam Tod, Ben D McNally, James A West, Julian L Griffin, Michael P Grocott, Michael G Mythen, Martin Feelisch, Andrew J Murray, Daniel S Martin
Feb 19, 2021
Mitochondrial redox and TCA cycle metabolite signaling in the heart.
Mitochondria are essential signaling organelles that regulate a broad range of cellular processes and thereby heart function. Multiple mechanisms participate in the communication between mitochondria and the nucleus that...
Control of mitochondrial superoxide production by reverse electron transport at complex I.
Ellen L Robb, Andrew R Hall, Tracy A Prime, Simon Eaton, Marten Szibor, Carlo Viscomi, Andrew M James, Michael P Murphy
Dec 17, 2018
The generation of mitochondrial superoxide (O2̇̄) by reverse electron transport (RET) at complex I causes oxidative damage in pathologies such as ischemia reperfusion injury, but also provides the precursor to H2O2 production in...
RET coenzyme Q Complex I Mitochondria mitochondrial membrane potential reactive oxygen species (ROS) redox signaling Respiration reverse electron transport Superoxide Animals Electron Transport Electron Transport Complex I Female Hydrogen Peroxide Male Mice Mice Inbred C57BL Mitochondria Heart Oxidative Phosphorylation Rats Rats Wistar Signal Transduction Superoxides Ubiquinone
Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly.
Elizabeth C Hinchy, Anja V Gruszczyk, Robin Willows, Naveenan Navaratnam, Andrew R Hall, Georgina Bates, Thomas P Bright, Thomas Krieg, David Carling, Michael P Murphy
Nov 21, 2018
Mitochondrial reactive oxygen species (ROS) production is a tightly regulated redox signal that transmits information from the organelle to the cell. Other mitochondrial signals, such as ATP, are sensed by enzymes, including the...
AMP-activated kinase (AMPK) Hydrogen Peroxide Mitochondria reactive oxygen species (ROS) redox signaling AMP-Activated Protein Kinases Adenosine Diphosphate Adenosine Triphosphate Animals Cell Line Enzyme Activation Humans Hydrogen Peroxide Mice Mitochondria Muscle Fibers Skeletal Oxidation-Reduction Reactive Oxygen Species
Inhibition of Mitochondrial Redox Signaling with MitoQ Prevents Metastasis of Human Pancreatic Cancer in Mice.
Tania Capeloa, Justine A Van de Velde, Donatienne d'Hose, Sara G Lipari, Françoise Derouane, Loïc Hamelin, Marie Bedin, Thibaut Vazeille, François P Duhoux, Michael P Murphy, Paolo E Porporato, Bernard Gallez, Pierre Sonveaux
Nov 16, 2022
At diagnosis, about 35% of pancreatic cancers are at the locally invasive yet premetastatic stage. Surgical resection is not a treatment option, leaving patients with a largely incurable disease that often evolves to the...
European contribution to the study of ROS
J Egea, I Fabregat, YM Frapart, P Ghezzi, A Görlach, T Kietzmann, K Kubaichuk, UG Knaus, MG Lopez, G Olaso-Gonzalez, A Petry, R Schulz, J Vina, P Winyard, K Abbas, OS Ademowo, CB Afonso, I Andreadou, H Antelmann, F Antunes, M Aslan, MM Bachschmid, RM Barbosa, V Belousov, C Berndt, D Bernlohr, E Bertrán, A Bindoli, SP Bottari, PM Brito, G Carrara, AI Casas, A Chatzi, N Chondrogianni, M Conrad, MS Cooke, JG Costa, A Cuadrado, P My-Chan Dang, B De Smet, B Debelec-Butuner, IHK Dias, JD Dunn, AJ Edson, M El Assar, J El-Benna, P Ferdinandy, AS Fernandes, KE Fladmark, U Förstermann, R Giniatullin, Z Giricz, A Görbe, H Griffiths, V Hampl, A Hanf, J Herget, P Hernansanz-Agustín, M Hillion, J Huang, S Ilikay, P Jansen-Dürr, V Jaquet, JA Joles, B Kalyanaraman, D Kaminskyy, M Karbaschi, M Kleanthous, L-O Klotz, B Korac, KS Korkmaz, R Koziel, D Kračun, K-H Krause, V Křen, T Krieg, J Laranjinha, A Lazou, H Li, A Martínez-Ruiz, R Matsui, GJ McBean, SP Meredith, J Messens, V Miguel, Y Mikhed, I Milisav, L Milković, A Miranda-Vizuete, M Mojović, M Monsalve, P-A Mouthuy, J Mulvey, T Münzel, V Muzykantov, ITN Nguyen, M Oelze, NG Oliveira, CM Palmeira, N Papaevgeniou, A Pavićević, B Pedre, F Peyrot, M Phylactides, GG Pircalabioru, AR Pitt, HE Poulsen, I Prieto, MP Rigobello, N Robledinos-Antón, L Rodríguez-Mañas, AP Rolo, F Rousset, T Ruskovska, N Saraiva, S Sasson, K Schröder, K Semen, T Seredenina, A Shakirzyanova, GL Smith, T Soldati, BC Sousa, CM Spickett, A Stancic, MJ Stasia, H Steinbrenner, V Stepanić, S Steven, K Tokatlidis, E Tuncay, B Turan, F Ursini, J Vacek, O Vajnerova, K Valentová, F Van Breusegem, L Varisli, EA Veal, AS Yalçın, O Yelisyeyeva, N Žarković, M Zatloukalová, J Zielonka, RM Touyz, A Papapetropoulos, T Grune, S Lamas, HHHW Schmidt, F Di Lisa, A Daiber
Aug 02, 2017