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Results: 17
Strategy for identifying dendritic cell-processed CD4+ T cell epitopes from the HIV Gag p24 protein
Mass Spectrometry (MS) is becoming a preferred method to identify class I and class II peptides presented on major histocompability complexes (MHC) on antigen presenting cells (APC). We describe a combined computational and MS...
Published by: Rockefeller University
Mechanisms of mouse spleen dendritic cell function in the generation of influenza-specific, cytolytic T lymphocytes
We have evaluated the capacity of dendritic ceUs to function as antigen-presenting cells (APCs) for influenza and have examined their mechanism of action. Virus-pulsed dendritic cells were 100 times more efficent than bulk...
antigen presenting cell cell function cytotoxic T lymphocyte dendritic cell Influenza virus protein synthesis spleen cell T lymphocyte ultraviolet irradiation Virus Replication
Published by: Rockefeller University
Newcastle disease virus expressing a dendritic cell-targeted HIV Gag protein induces a potent Gag-specific immune response in mice
Viral vaccine vectors have emerged as an attractive strategy for the development of a human immunodeficiency virus (HIV) vaccine. Recombinant Newcastle disease virus (rNDV) stands out as a vaccine vector since it has a proven...
Published by: Rockefeller University
The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies
Metlay, J.P., Witmer-Pack, M.D., Agger, R., Crowley, M.T., Lawless, D., and Steinman, R.M. The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies. J. Exp. Med. 171...
antigen presenting cell cytochemistry dendritic cell Monoclonal antibody spleen cell membrane antigen
Published by: The Rockefeller University Press
Accessory cell-T lymphocyte interactions. antigen-dependent and -independent clustering
[No abstract available]
Published by: Rockefeller University
The linkage of innate to adaptive immunity via maturing dendritic cells in vivo requires CD40 ligation in addition to antigen presentation and CD80/86 costimulation
Dendritic cell (DC) maturation is an innate response that leads to adaptive immunity to coadministered proteins. To begin to identify underlying mechanisms in intact lymphoid tissues, we studied ?-galactosylceramide. This...
Published by: Rockefeller University
Dendritic cells are accessory cells for the development of anti-trinitrophenyl cytotoxic T lymphocytes
This study establishes that dendritic cells (DC) are the critical accessory cells for the development of anti-trinitrophenol (TNP) cytotoxic T lymphocytes (CTL) in vitro. We developed a model in which nylon wool-nonadherent...
Published by: Rockefeller University
The CD8+ dendritic cell subset selectively endocytoses dying cells in culture and in vivo
Dendritic cells (DCs) are able in tissue culture to phagocytose and present antigens derived from infected, malignant, and allogeneic cells. Here we show directly that DCs in situ take up these types of cells after fluorescent...
Published by: Rockefeller University
Dendritic cells are accessory cells for the development of anti-trinitrophenyl cytotoxic T lymphocytes
Nussenzweig, M.C., Steinman, R.M., Gutchinov, B., and Cohn, Z.A. Dendritic cells are accessory cells for the development of anti-trinitrophenyl cytotoxic T lymphocytes. J. Exp. Med. 152: 1070-1084, 1980
Published by: The Rockefeller University Press
Dendritic cells initiate a two-stage mechanism for T lymphocyte proliferation
[No abstract available]
Published by: Rockefeller University
Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells
The capacity of dendritic cells to present protein antigens has been studied with two MHC class II-restricted, myoglobin-specific, T cell clones. Spleen dendritic cells and cultured epidermal Langerhans cells (LC) presented...
Myoglobin Antigen Presentation cell clone dendritic cell angerhans cell mixed lymphocyte reaction spleen cell T lymphocyte
Published by: Rockefeller University
Dendritic cells induce antigen-specific regulatory T cells that prevent graft versus host disease and persist in mice
Foxp3 + regulatory T cells (T reg cells) effectively suppress immunity, but it is not determined if antigen-induced T reg cells (iT reg cells) are able to persist under conditions of inflammation and to stably express the...
regulatory T lymphocyte spleen cell dendritic cell graft versus host reaction mixed lymphocyte reaction
Published by: Rockefeller University
Presentation of exogenous protein antigens by dendritic cells to T cell clones: intact protein is presented best by immature, epidermal Langerhans cells
Romani, N., Koide, S., Crowley, M., Witmer-Pack, M., Livingston, A.M., Fathman, C.G., Inaba, K., and Steinman, R.M. Presentation of exogenous protein antigens by dendritic cells to T cell clones: intact protein is presented best...
Myoglobin Antigen Presentation cell clone dendritic cell angerhans cell mixed lymphocyte reaction spleen cell T lymphocyte
Published by: The Rockefeller University Press
Contribution of dendritic cells to stimulation of the murine syngeneic mixed leukocyte reaction
We have studied the proliferative response of unprimed T cells to syngeneic dendritic cells (DC) (syngeneic mixed leukocyte rection [SMLR]) in cultures of mouse spleen and lymph node. T cells purified by passage over nylon wool...
Published by: Rockefeller University
Accessory cell - T lymphocyte interactions: antigen dependent and independent clustering
Inaba, K., and Steinman, R.M. Accessory cell - T lymphocyte interactions: antigen dependent and independent clustering. J. Exp. Med. 163: 247-261, 1986
Published by: The Rockefeller University Press