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Results: 13
The Helicase Aquarius/EMB-4 Is Required to Overcome Intronic Barriers to Allow Nuclear RNAi Pathways to Heritably Silence Transcription
A Akay, T Di Domenico, KM Suen, A Nabih, GE Parada, M Larance, R Medhi, Berkyurek, X Zhang, CJ Wedeles, Rudolph, J Engelhardt, M Hemberg, P Ma, AI Lamond, JM Claycomb, Miska
Jul 16, 2017
Maternally inherited piRNAs direct transient heterochromatin formation at active transposons during early Drosophila embryogenesis.
Martin H Fabry, Federica A Falconio, Fadwa Joud, Emily K Lythgoe, Benjamin Czech, Gregory J Hannon
Jul 13, 2021
The PIWI-interacting RNA (piRNA) pathway controls transposon expression in animal germ cells, thereby ensuring genome stability over generations. In Drosophila, piRNAs are intergenerationally inherited through the maternal...
D. melanogaster Drosophila Chromatin Chromosomes developmental biology embryogenesis epigenetics Gene Expression piRNA pathway transposable elements Animals Chromatin DNA Transposable Elements developmental biology Drosophila Drosophila Proteins Drosophila melanogaster Embryonic Development Epigenomics Female Gene Expression Germ Cells Heterochromatin Histones Male Maternal Inheritance RNA Small Interfering
Molecular Criteria for Defining the Naive Human Pluripotent State.
Thorold W Theunissen, Marc Friedli, Yupeng He, Evarist Planet, Ryan C O'Neil, Styliani Markoulaki, Julien Pontis, Haoyi Wang, Alexandra Iouranova, Michaël Imbeault, Julien Duc, Malkiel A Cohen, Katherine J Wert, Rosa Castanon, Zhuzhu Zhang, Yanmei Huang, Joseph R Nery, Jesse Drotar, Tenzin Lungjangwa, Didier Trono, Joseph R Ecker, Rudolf Jaenisch
Jul 07, 2016
DNA Methylation X chromosome reactivation Embryonic Stem Cells Imprinting mouse-human chimeras Pluripotency transposable elements Animals Blastocyst Cell Differentiation Cell Line Chimera Chromosomes Human X Cleavage Stage Ovum DNA Methylation DNA Transposable Elements DNA Mitochondrial Female Gene Expression Profiling Genome Human Genomic Imprinting Human Embryonic Stem Cells Humans Male Mice Mitochondria Morula Pluripotent Stem Cells Polymerase Chain Reaction Transcription Genetic
LINE retrotransposons characterize mammalian tissue-specific and evolutionarily dynamic regulatory regions.
Maša Roller, Ericca Stamper, Diego Villar, Osagie Izuogu, Fergal Martin, Aisling M Redmond, Raghavendra Ramachanderan, Louise Harewood, Duncan T Odom, Paul Flicek
Feb 18, 2021
Enhancers Gene regulation LINE L1 LINE L2 Long Interspersed Nuclear Elements (LINEs) Mammals Promoters regulatory evolution transposable elements Animals Chromosome Mapping Conserved Sequence Enhancer Elements Genetic evolution Molecular Gene Expression Regulation Humans Long Interspersed Nucleotide Elements Mammals Organ Specificity Promoter Regions Genetic Regulatory Sequences Nucleic Acid Retroelements
Large Drosophila germline piRNA clusters are evolutionarily labile and dispensable for transposon regulation.
Daniel Gebert, Lena K Neubert, Catrin Lloyd, Jinghua Gui, Ruth Lehmann, Felipe Karam Teixeira
Jul 13, 2021
chromosome inversions flamenco Fruit fly Gene Silencing Germ Cells gypsy12 Heterochromatin POSITION-EFFECT VARIEGATION sterility transposable elements Animals Animals Genetically Modified Argonaute Proteins Chromosome Deletion Chromosomes Insect DNA Transposable Elements Drosophila Proteins Drosophila melanogaster evolution Molecular Female Fertility Gene Expression Regulation Developmental Multigene Family Ovary RNA Stability RNA Small Interfering
Maternally inherited piRNAs direct transient heterochromatin formation at active transposons during early Drosophila embryogenesis
Martin H Fabry, Federica A Falconio, Fadwa Joud, Emily K Lythgoe, Benjamin Czech, Gregory J Hannon
Aug 11, 2021
The PIWI-interacting RNA (piRNA) pathway controls transposon expression in animal germ cells, thereby ensuring genome stability over generations. In Drosophila, piRNAs are intergenerationally inherited through the maternal...
Becoming a Selfish Clan
Transposable elements (TEs) are parasitic DNA bits capable of mobilization and mutagenesis, typically suppressed by host's epigenetic silencing. Since the selfish DNA concept, it is appreciated that genomes are also molded by...
LTR retrotransposons epigenetics Recombination Retroelements reverse-transcription transcriptional gene silencing transposable elements transposons Epigenesis Genetic evolution Molecular Gene Silencing Genetic Speciation Recombination Genetic Retroelements reverse transcription selection Genetic Terminal Repeat Sequences
ZFP57 regulation of transposable elements and gene expression within and beyond imprinted domains
Hui Shi, Ruslan Strogantsev, Nozomi Takahashi, Anastasiya Kazachenka, Matthew C. Lorincz, Myriam Hemberger, Anne C. Ferguson-Smith
Aug 08, 2020
Abstract: Background: KRAB zinc finger proteins (KZFPs) represent one of the largest families of DNA-binding proteins in vertebrate genomes and appear to have evolved to silence transposable elements (TEs) including endogenous...
A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis.
Nicolas Altemose, Nudrat Noor, Emmanuelle Bitoun, Afidalina Tumian, Michael Imbeault, J Ross Chapman, A Radu Aricescu, Simon R Myers
Sep 05, 2018
PRDM9 binding localizes almost all meiotic recombination sites in humans and mice. However, most PRDM9-bound loci do not become recombination hotspots. To explore factors that affect binding and subsequent recombination...
ZFP57 regulation of transposable elements and gene expression within and beyond imprinted domains.
Hui Shi, Ruslan Strogantsev, Nozomi Takahashi, Anastasiya Kazachenka, Matthew C Lorincz, Myriam Hemberger, Anne C Ferguson-Smith
Jul 30, 2019
BACKGROUND: KRAB zinc finger proteins (KZFPs) represent one of the largest families of DNA-binding proteins in vertebrate genomes and appear to have evolved to silence transposable elements (TEs) including endogenous...
Stella modulates transcriptional and endogenous retrovirus programs during maternal-to-zygotic transition
Y Huang, JK Kim, DV Do, C Lee, CA Penfold, JJ Zylicz, JC Marioni, JA Hackett, MA Surani
Jun 07, 2017
Transposon-Derived Non-coding RNAs and Their Function in Plants.
Jungnam Cho
Sep 08, 2018
Transposable elements (TEs) are often regarded as harmful genomic factors and indeed they are strongly suppressed by the epigenetic silencing mechanisms. On the other hand, the mobilization of TEs brings about variability of...