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Results: 16574
Evaluation of <sup>11</sup>C-BU99008, a PET Ligand for the Imidazoline Binding Sites in Rhesus Brain
C.A. Parker, N. Nabulsi, D. Holden, S.-F. Lin, T. Cass, D. Labaree, S. Kealey, A.D. Gee, S.M. Husbands, D. Quelch, R.E. Carson, D.J. Nutt, Y. Huang, R.J. Tyacke
May 01, 2014
The development of a PET radioligand selective for I2-imidazoline binding sites (I2BS) would enable, for the first time, specific, measurable in vivo imaging of this target protein, along with assessment...
Comparison of mesospheric winds from a high-altitude meteorological analysis system and meteor radar observations during the boreal winters of 2009–2010 and 2012–2013
J. McCormack, K. Hoppel, D. Kuhl, R. de Wit, G. Stober, P. Espy, N. Baker, P. Brown, D. Fritts, C. Jacobi, D. Janches, N. Mitchell, B. Ruston, S. Swadley, K. Viner, T. Whitcomb, R. Hibbins
Feb 01, 2017
We present a study of horizontal winds in the mesosphere and lower thermosphere (MLT) during the boreal winters of 2009–2010 and 2012–2013 produced with a new high-altitude numerical weather prediction (NWP) system. This...
Macromolecular structure determination using X-rays, neutrons and electrons
Dorothee Liebschner, Pavel V Afonine, Matthew L Baker, Gábor Bunkóczi, Vincent B Chen, Tristan I Croll, Bradley Hintze, Li Wei Hung, Swati Jain, Airlie J McCoy, Nigel W Moriarty, Robert D Oeffner, Billy K Poon, Michael G Prisant, Randy J Read, Jane S Richardson, David C Richardson, Massimo D Sammito, Oleg V Sobolev, Duncan H Stockwell, Thomas C Terwilliger, Alexandre G Urzhumtsev, Lizbeth L Videau, Christopher J Williams, Paul D Adams
Aug 19, 2019
Diffraction (X-ray, neutron and electron) and electron cryo-microscopy are powerful methods to determine three-dimensional macromolecular structures, which are required to understand biological processes and to develop new...
Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH
Na Zhu, Emilia M. Swietlik, Carrie L. Welch, Michael W. Pauciulo, Jacob J. Hagen, Xueya Zhou, Yicheng Guo, Johannes Karten, Divya Pandya, Tobias Tilly, Katie A. Lutz, Jennifer M. Martin, Carmen M. Treacy, Erika B. Rosenzweig, Usha Krishnan, Anna W. Coleman, Claudia Gonzaga-Jauregui, Allan Lawrie, Richard C. Trembath, Martin R. Wilkins, Nicholas W. Morrell, Yufeng Shen, Stefan Gräf, William C. Nichols, Wendy K. Chung, Russel Hirsch, R. James White, Marc Simon, David Badesch, Erika Rosenzweig, Charles Burger, Murali Chakinala, Thenappan Thenappan, Greg Elliott, Robert Simms, Harrison Farber, Robert Frantz, Jean Elwing, Nicholas Hill, Dunbar Ivy, James Klinger, Steven Nathan, Ronald Oudiz, Ivan Robbins, Robert Schilz, Terry Fortin, Jeffrey Wilt, Delphine Yung, Eric Austin, Ferhaan Ahmad, Nitin Bhatt, Tim Lahm, Adaani Frost, Zeenat Safdar, Zia Rehman, Robert Walter, Fernando Torres, Sahil Bakshi, Stephen Archer, Rahul Argula, Christopher Barnett, Raymond Benza, Ankit Desai, Veeranna Maddipati, Harm J. Bogaard, Colin Church, Gerry Coghlin, Robin Condliffe, Mélanie Eyries, Henning Gall, Stefano Ghio, Barbara Girerd, Simon Holden, Luke Howard, Marc Humbert, David G. Kiely, Gabor Kovacs, Jim Lordan, Rajiv D. Machado, Robert V. MacKenzie Ross, Colm McCabe, Shahin Moledina, David Montani, Horst Olschewski, Christopher J. Penkett, Joanna Pepke-Zaba, Laura Price, Christopher J. Rhodes, Werner Seeger, Florent Soubrier, Laura Southgate, Jay Suntharalingam, Andrew J. Swift, Mark R. Toshner, Anton Vonk Noordegraaf, John Wharton, Jim Wild, Stephen John Wort
Jun 22, 2021
Abstract: Background: Pulmonary arterial hypertension (PAH) is a lethal vasculopathy characterized by pathogenic remodeling of pulmonary arterioles leading to increased pulmonary pressures, right ventricular hypertrophy, and...
Early Onset Prion Disease from Octarepeat Expansion Correlates with Copper Binding Properties
D J Stevens, E D Walter, A Rodriguez, D Draper, Paul Davies, David R Brown, G L Millhauser
Jan 01, 0001
Insertional mutations leading to expansion of the octarepeat domain of the prion protein (PrP) are directly linked to prion disease. While normal PrP has four PHGGGWGQ octapeptide segments in its flexible N-terminal domain...
Comparative mapping of the 22q11.2 deletion region and the potential of simple model organisms.
BACKGROUND: 22q11.2 deletion syndrome (22q11.2DS) is the most common micro-deletion syndrome. The associated 22q11.2 deletion conveys the strongest known molecular risk for schizophrenia. Neurodevelopmental phenotypes, including...
On the system of numeration in Efik
Eyo O. Mensah
Oct 05, 2013
This paper is a response to Olderroge 1984 that Efik does not have a system of number beyond one thousand, since according to the claim, the word for thousand in Efik is tosin, a recent borrowing from English and assimilated...
Published by: Atlantic Provinces Linguistic Association
Assessing Anti-HCMV Cell Mediated Immune Responses in Transplant Recipients and Healthy Controls Using a Novel Functional Assay
Charlotte J. Houldcroft, Sarah E. Jackson, Eleanor Y. Lim, George X. Sedikides, Emma L. Davies, Claire Atkinson, Megan McIntosh, Ester B. M. Remmerswaal, Georgina Okecha, Frederike J. Bemelman, Richard J. Stanton, Matthew Reeves, Mark R. Wills
Jul 10, 2020
HCMV infection, reinfection or reactivation occurs in 60% of untreated solid organ transplant (SOT) recipients. Current clinical approaches to HCMV management include pre-emptive and prophylactic antiviral treatment strategies....
Altering the availability of healthier vs. less healthy items in UK hospital vending machines
Abstract: Background: Altering the availability of healthier or less-healthy products may increase healthier purchases, but evidence is currently limited. The current study aimed to investigate the impact of altering the...
Once more with feeling
D Skidmore
Mar 01, 2008
Trust in numbers
Summary
Those who value quantitative and scientific evidence are faced with claims both of a reproducibility crisis in scientific publication and of a post-truth society abounding...
D Spiegelhalter
Aug 18, 2017
On the system of numeration in Efik
Eyo O. Mensah
Oct 05, 2013
This paper is a response to Olderroge 1984 that Efik does not have a system of number beyond one thousand, since according to the claim, the word for thousand in Efik is tosin, a recent borrowing from English and assimilated...
Published by: Atlantic Provinces Linguistic Association
Altering the availability of healthier vs. less healthy items in UK hospital vending machines
BACKGROUND:Altering the availability of healthier or less-healthy products may increase healthier purchases, but evidence is currently limited. The current study aimed to investigate the impact of altering the...
Brain Structure in Acutely Underweight and Partially Weight-Restored Individuals with Anorexia Nervosa - A Coordinated Analysis by the ENIGMA Eating Disorders Working Group
Esther Walton, Fabio Bernardoni, Victoria-Luise Batury, Klaas Bahnsen, Sara Larivière, Giovanni Abbate-Daga, Susana Andres-Perpiña, Lasse Bang, Amanda Bischoff-Grethe, Samantha J. Brooks, Iain C. Campbell, Giammarco Cascino, Josefina Castro-Fornieles, Enrico Collantoni, Federico D'Agata, Brigitte Dahmen, Unna N. Danner, Angela Favaro, Jamie D. Feusner, Guido KW. Frank, Hans-Christoph Friederich, John L. Graner, Beate Herpertz-Dahlmann, Andreas Hess, Stefanie Horndasch, Allan S. Kaplan, Lisa-Katrin Kaufmann, Walter H. Kaye, Sahib S. Khalsa, Kevin S. LaBar, Luca Lavagnino, Luisa Lazaro, Renzo Manara, Amy E. Miles, Gabriella F. Milos, Maria Monteleone Alessio, Palmiero Monteleone, Benson Mwangi, Owen O'Daly, Jose Pariente, Julie Roesch, Ulrike H. Schmidt, Jochen Seitz, Megan E. Shott, Joe J. Simon, Paul A.M. Smeets, Christian K. Tamnes, Elena Tenconi, Sophia I. Thomopoulos, Annemarie A. van Elburg
Nov 01, 2022
Background: The pattern of structural brain abnormalities in anorexia nervosa (AN) is still not well understood. While several studies report substantial deficits in gray matter volume and cortical thickness in acutely...
Environmental variability supports chimpanzee behavioural diversity
Ammie K. Kalan, Lars Kulik, Mimi Arandjelovic, Christophe Boesch, Fabian Haas, Paula Dieguez, Christopher D. Barratt, Ekwoge E. Abwe, Anthony Agbor, Samuel Angedakin, Floris Aubert, Emmanuel Ayuk Ayimisin, Emma Bailey, Mattia Bessone, Gregory Brazzola, Valentine Ebua Buh, Rebecca Chancellor, Heather Cohen, Charlotte Coupland, Bryan Curran, Emmanuel Danquah, Tobias Deschner, Dervla Dowd, Manasseh Eno-Nku, J. Michael Fay, Annemarie Goedmakers, Anne-Céline Granjon, Josephine Head, Daniela Hedwig, Veerle Hermans, Kathryn J. Jeffery, Sorrel Jones, Jessica Junker, Parag Kadam, Mohamed Kambi, Ivonne Kienast, Deo Kujirakwinja, Kevin E. Langergraber, Juan Lapuente, Bradley Larson, Kevin C. Lee, Vera Leinert, Manuel Llana, Sergio Marrocoli, Amelia C. Meier, Bethan Morgan, David Morgan, Emily Neil, Sonia Nicholl, Emmanuelle Normand, Lucy Jayne Ormsby, Liliana Pacheco, Alex Piel, Jodie Preece, Martha M. Robbins, Aaron Rundus, Crickette Sanz, Volker Sommer, Fiona Stewart, Nikki Tagg, Claudio Tennie, Virginie Vergnes, Adam Welsh, Erin G. Wessling, Jacob Willie, Roman M. Wittig, Yisa Ginath Yuh, Klaus Zuberbühler, Hjalmar S. Kühl
Jan 27, 2021
Coagulation factor V is a T-cell inhibitor expressed by leukocytes in COVID-19.
Jun Wang, Prasanti Kotagiri, Paul A Lyons, Rafia S Al-Lamki, Federica Mescia, Laura Bergamaschi, Lorinda Turner, Michael D Morgan, Fernando J Calero-Nieto, Karsten Bach, Nicole Mende, Nicola K Wilson, Emily R Watts, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration, Patrick H Maxwell, Patrick F Chinnery, Nathalie Kingston, Sofia Papadia, Kathleen E Stirrups, Neil Walker, Ravindra K Gupta, David K Menon, Kieren Allinson, Sarah J Aitken, Mark Toshner, Michael P Weekes, James A Nathan, Sarah R Walmsley, Willem H Ouwehand, Mary Kasanicki, Berthold Göttgens, John C Marioni, Kenneth GC Smith, Jordan S Pober, John R Bradley
Mar 30, 2022
Potential To Streamline Heterologous DNA Prime and NYVAC/Protein Boost HIV Vaccine Regimens in Rhesus Macaques by Employing Improved Antigens.
Benedikt Asbach, Alexander Kliche, Josef Köstler, Beatriz Perdiguero, Mariano Esteban, Bertram L Jacobs, David C Montefiori, Celia C LaBranche, Nicole L Yates, Georgia D Tomaras, Guido Ferrari, Kathryn E Foulds, Mario Roederer, Gary Landucci, Donald N Forthal, Michael S Seaman, Natalie Hawkins, Steven G Self, Alicia Sato, Raphael Gottardo, Sanjay Phogat, James Tartaglia, Susan W Barnett, Brian Burke, Anthony D Cristillo, Deborah E Weiss, Jesse Francis, Lindsey Galmin, Song Ding, Jonathan L Heeney, Giuseppe Pantaleo, Ralf Wagner
Apr 21, 2016
Major merging history in CANDELS. I. Evolution of the incidence of massive galaxy–galaxy pairs from z = 3 to z ∼ 0
Kameswara Bharadwaj Mantha, Daniel H. McIntosh, Ryan Brennan, Henry C. Ferguson, Dritan Kodra, Jeffrey A. Newman, Marc Rafelski, Rachel S. Somerville, Christopher J. Conselice, Joshua S Cook, Nimish P. Hathi, David C. Koo, Jennifer M. Lotz, Brooke D Simmons, Amber N. Straughn, Gregory F Snyder, Stijn Wuyts, Eric F. Bell, Avishai Dekel, Jeyhan S. Kartaltepe, Dale D. Kocevski, Anton M. Koekemoer, Seong Kook Lee, Ray A. Lucas, Camilla Pacifici, Michael A Peth, Guillermo Barro, Tomas Dahlen, Steven L. Finkelstein, Adriano Fontana, Audrey Galametz, Norman A. Grogin, Yicheng Guo, Bahram Mobasher, Hooshang Nayyeri, Pablo G. Pérez-González, Janine Pforr, Paola Santini, Mauro Stefanon, Tommy Wiklind
Apr 01, 2018
The rate of major galaxy–galaxy merging is theoretically predicted to steadily increase with redshift during the peak epoch of massive galaxy development (1 ≤ z ≤ 3). We use close-pair statistics to objectively study the...
Epigenome-Wide Association Study of Incident Type 2 Diabetes in a British Population
Alexia Cardona, Felix R Day, John RB Perry, Marie Loh, Audrey Y Chu, Benjamin Lehne, Dirk S Paul, Luca A Lotta, Isobel D Stewart, Nicola D Kerrison, Robert A Scott, Kay-Tee Khaw, Nita G Forouhi, Claudia Langenberg, Chunyu Liu, Michael M Mendelson, Daniel Levy, Stephan Beck, R David Leslie, Josée Dupuis, James B Meigs, Jaspal S Kooner, Jussi Pihlajamäki, Allan Vaag, Alexander Perfilyev, Charlotte Ling, Marie-France Hivert, John C Chambers, Nicholas J Wareham, Ken K Ong
Sep 20, 2019
Epigenetic changes may contribute substantially to risks of diseases of aging. Previous studies reported seven methylation variable positions (MVPs) robustly associated with incident type 2 diabetes mellitus (T2DM). However...
Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility.
Hamdi Mbarek, Stacy Steinberg, Dale R Nyholt, Scott D Gordon, Michael B Miller, Allan F McRae, Jouke Jan Hottenga, Felix R Day, Gonneke Willemsen, Eco J de Geus, Gareth E Davies, Hilary C Martin, Brenda W Penninx, Rick Jansen, Kerrie McAloney, Jacqueline M Vink, Jaakko Kaprio, Robert Plomin, Tim D Spector, Patrik K Magnusson, Bruno Reversade, R Alan Harris, Kjersti Aagaard, Ragnar P Kristjansson, Isleifur Olafsson, Gudmundur Ingi Eyjolfsson, Olof Sigurdardottir, William G Iacono, Cornelis B Lambalk, Grant W Montgomery, Matt McGue, Ken K Ong, John RB Perry, Nicholas G Martin, Hreinn Stefánsson, Kari Stefánsson, Dorret I Boomsma
May 17, 2016
Stoichiometric and catalytic C-F bond activation by the<i> trans</i>-dihydride complex [Ru(IEt<sub>2</sub>Me<sub>2</sub>)<sub>2</sub>(PPh<sub>3</sub>)<sub>2</sub>H<sub>2</sub>] (IEt<sub>2</sub>Me<sub>2</sub> = 1,3-diethyl-4,5-dimethylimidazol-2-ylidene)
Mateusz K. Cybulski, Ian M. Riddlestone, Mary F. Mahon, Timothy J. Woodman, Michael K. Whittlesey
Jan 01, 0001
The room temperature reaction of C6F6 or C6F5H with [Ru(IEt2Me2)2(PPh3)2H¬2] (1; IEt2Me2 = 1,3-diethyl-4,5-dimethylimidazol-2-ylidene) generated a mixture of the trans-hydride fluoride complex [Ru(IEt2Me2)2(PPh3)2HF] (2) and the...
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