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Increased hepatic oxidative metabolism distinguishes the action of Peroxisome proliferator-activated receptor delta from Peroxisome proliferator-activated receptor gamma in the ob/ob mouse.
Lee D Roberts, David G Hassall, Deborah A Winegar, John N Haselden, Andrew W Nicholls, Julian L Griffin
Jun 17, 2011
BACKGROUND: The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors and members of the nuclear receptor superfamily. The PPAR family consists of three members: PPARalpha, PPARgamma, and...
Translational neurophysiology in sheep
Nicholas Perentos, Amadeu Q Martins, Thomas C Watson, Ullrich Bartsch, Nadia L Mitchell, David N Palmer, Matthew W Jones, A Jennifer Morton
Mar 23, 2015
NCL brain atrophy Epilepsy experimental models lysosomal storage disease neurodegeneration neuronal ceroid lipofuscinosis Seizures Animals Disease Models Animal Humans Lysosome-Associated Membrane Glycoproteins Membrane Proteins Nervous System Diseases Neuronal Ceroid-Lipofuscinoses Sheep Sleep Translational Research Biomedical
Contribution to the benchmark for ternary mixtures
Miren Larrañaga, M. Mounir Bou-Ali, David Alonso de Mezquıa, D. Andrew S Rees, Jose Antonio Madariaga, Carlos Santamaría, Jean K. Platten
Apr 01, 2015
This work is part of an international project for the research on the transport properties in ternary mixtures. Six different teams have analysed the same mixture by independent techniques in order to compare the results and...
H2FC SUPERGEN
Chloe Stockford, Nigel Brandon, John Irvine, Tim Mays, Ian Metcalfe, David Book, Paul Ekins, Anthony Kucernak, Vladimir Molkov, Robert Steinberger-Wilckens, Nilay Shah, Paul Dodds, Cristina Dueso, Sheila Samsatli, Claire Thompson
Apr 27, 2015
The United Kingdom has a vast scientific base across the entire Hydrogen and Fuel Cell research landscape, with a world class academic community coupled with significant industrial activity from both UK-based Hydrogen and...
Structure of a single-chain Fv bound to the 17 N-terminal residues of huntingtin provides insights into pathogenic amyloid formation and suppression.
Erwin De Genst, Dimitri Y Chirgadze, Fabrice AC Klein, David C Butler, Dijana Matak-Vinković, Yvon Trottier, James S Huston, Anne Messer, Christopher M Dobson
May 27, 2015
Huntington's disease aggregation inhibition Amyloid prefibrillar intermediates single-chain Fv antibody Amyloid Chemical Phenomena Crystallography X-Ray Humans Huntingtin Protein Magnetic Resonance Spectroscopy Models Molecular Nerve Tissue Proteins Protein Binding Protein Multimerization Protein Structure Quaternary Single-Chain Antibodies
Business and Social Mobility
Alan Milburn, Gillian Shephard, Paul Cleal, David Johnston, Tom Attwood, P Gregg, Douglas Hamilton, Anne Marie Carrie, Christian Guy, Catriona Williams
Oct 01, 2013
Organisations are only as good as their people, so it’s vital for business success that firms identify and recruit the best individuals. Yet there’s growing evidence that when it comes to making the most of their assets, some of...
Published by: Social Mobility & Child Poverty (SMCP) Commission
Comparison of native anatomy with recommended safe component orientation in total hip arthroplasty for primary osteoarthritis
Christian Merle, George Grammatopoulos, Wenzel Waldstein, Elise Pegg, Hemant Pandit, Peter R. Aldinger, Harinderjit S. Gill, David W. Murray
Nov 20, 2013
The adverse consequences of impingement, dislocation, and implant wear have stimulated increasing interest in accurate component orientation in total hip arthroplasty and hip resurfacing. The aims of the present study were to...
Loop diuretics are open-channel blockers of the cystic fibrosis transmembrane conductance regulator with distinct kinetics
Min Ju, Toby S Scott-ward, Jia Liu, Pissared Khuituan, Hongyu Li, Zhiwei Cai, Stephen M Husbands, David N Sheppard
Jan 01, 2014
Background and Purpose Loop diuretics are widely used to inhibit the Na+, K+, 2Cl- co-transporter, but they also inhibit the cystic fibrosis transmembrane conductance regulator (CFTR) Cl - channel. Here, we investigated the...
Preparation of stereoregular isotactic poly(mandelic acid) through organocatalytic ring-opening polymerization of a cyclic O-carboxyanhydride
Antoine Buchard, David R Carbery, Matthew G Davidson, Petya K Ivanova, Ben J Jeffery, Gabriele Kociok-Köhn, John P Lowe
Dec 02, 2014
Poly(mandelic acid) (PMA) is an aryl analogue of poly(lactic acid) (PLA) and a biodegradable analogue of polystyrene. The preparation of stereoregular PMA was realized using a pyridine/mandelic acid adduct (Py⋅MA) as an...
Future Directions for Whole Atmosphere Modeling
David R. Jackson, Tim J. Fuller-Rowell, Dan J. Griffin, Matthew J. Griffith, Christopher W. Kelly, Daniel R. Marsh, Maria Theresia Walach
Sep 01, 2019
Coupled Sun-to-Earth models represent a key part of the future development of space weather forecasting. With respect to predicting the state of the thermosphere and ionosphere, there has been a recent paradigm shift; it is...
Altering the availability or proximity of food, alcohol, and tobacco products to change their selection and consumption.
Gareth J Hollands, Patrice Carter, Sumayya Anwer, Sarah E King, Susan A Jebb, David Ogilvie, Ian Shemilt, Julian PT Higgins, Theresa M Marteau
Sep 06, 2019
BACKGROUND: Overconsumption of food, alcohol, and tobacco products increases the risk of non-communicable diseases. Interventions to change characteristics of physical micro-environments where people may select or consume these...
Mitochondrial pathology in progressive cerebellar ataxia.
David Bargiela, Priya Shanmugarajah, Christine Lo, Emma L Blakely, Robert W Taylor, Rita Horvath, Stephen Wharton, Patrick F Chinnery, Marios Hadjivassiliou
Sep 06, 2019
BACKGROUND: Mitochondrial disease can manifest as multi-organ disorder, often with neurological dysfunction. Cerebellar ataxia in isolation or in combination with other features can result from mitochondrial disease yet genetic...
An advanced single-stage turbine facility for investigating non-axisymmetric contoured endwalls in the presence of purge flow
Robin Jones, Oliver Pountney, Bjorn Cleton, Liam Wood, Buchan Schreiner, Artur Joao Carvalho Batista Soares De Figueiredo, James Scobie, David Cleaver, Gary Lock, Carl Sangan
Oct 01, 2019
In modern gas turbines, endwall contouring (EWC) is employed to modify the static pressure field downstream of the vanes and minimise the growth of secondary flow structures developed in the blade passage. Purge flow (or egress)...
The association of maternal nutrition and children's pre-primary experience with over-age attendance in secondary school
Akanksha A Marphatia, Jonathan CK Wells, Alice M Reid, Mario Cortina Borja, Dharma S Manandhar, Aman Sen, Naomi Saville, Delan Devakumar, David Osrin, Audrey Prost, Sophiya Dulal
Oct 08, 2019
•Over-age attendance is increasing but remains under-studied in South Asia.•Children fall behind by entering pre-primary or primary late, and by repeating a grade during/after primary school.•Rural location, thin and uneducated...
Relationship Between Measures of Cerebrovascular Reactivity and Intracranial Lesion Progression in Acute TBI Patients
François Mathieu, Frederick A Zeiler, Daniel P Whitehouse, Tilak Das, Ari Ercole, Peter Smielewski, Peter J Hutchinson, Marek Czosnyka, Virginia FJ Newcombe, David K Menon
Nov 13, 2019
BACKGROUND: Failure of cerebral autoregulation and progression of intracranial lesion have both been shown to contribute to poor outcome in patients with acute traumatic brain injury (TBI), but the interplay between the two...
Neurophysiological Monitoring Traumatic brain injury Traumatic intracranial hemorrhage Adult Arterial Pressure Brain Contusion Brain Edema Brain Injuries Traumatic Cerebrovascular Circulation Disease Progression Female Glasgow Coma Scale Glasgow Outcome Scale Homeostasis Humans Intensive Care Units Intracranial hemorrhage Traumatic Intracranial Pressure Male Middle Aged Retrospective Studies Tomography X-Ray Computed Young Adult
Cycloaddition Strategies for the Synthesis of Diverse Heterocyclic Spirocycles for Fragment-Based Drug Discovery.
Thomas A King, Hannah L Stewart, Kim T Mortensen, Andrew JP North, Hannah F Sore, David R Spring
Jul 12, 2019
In recent years the pharmaceutical industry has benefited from the advances made in fragment-based drug discovery (FBDD) with more than 30 fragment-derived drugs currently marketed or progressing through clinical trials. The...
Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures.
Berna Sozen, Gianluca Amadei, Andy Cox, Ran Wang, Ellen Na, Sylwia Czukiewska, Lia Chappell, Thierry Voet, Geert Michel, Naihe Jing, David M Glover, Magdalena Zernicka-Goetz
Jul 17, 2019
Animals Cell Communication Cell Differentiation Cell Line Cell Lineage Cell Movement Coculture Techniques Embryo Mammalian Endoderm Epithelial-Mesenchymal Transition Gastrulation Gene Expression Regulation Developmental Gestational Age Mice Mouse embryonic stem cells Phenotype Transcriptome Trophoblasts
Limited capacity of tree growth to mitigate the global greenhouse effect under predicted warming.
Ulf Büntgen, Paul J Krusic, Alma Piermattei, David A Coomes, Jan Esper, Vladimir S Myglan, Alexander V Kirdyanov, J Julio Camarero, Alan Crivellaro, Christian Körner
Jul 18, 2019
It is generally accepted that animal heartbeat and lifespan are often inversely correlated, however, the relationship between productivity and longevity has not yet been described for trees growing under industrial and...
Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis.
Christian Stockmann, Andrew Doedens, Alexander Weidemann, Na Zhang, Norihiko Takeda, Joshua I Greenberg, David A Cheresh, Randall S Johnson
Mar 13, 2020
Angiogenesis and the development of a vascular network are required for tumour progression, and they involve the release of angiogenic factors, including vascular endothelial growth factor (VEGF-A), from both malignant and...
Computational saturation mutagenesis to predict structural consequences of systematic mutations in the beta subunit of RNA polymerase in Mycobacterium leprae
Sundeep Chaitanya Vedithi, Carlos Hm Rodrigues, Stephanie Portelli, Marcin J Skwark, Madhusmita Das, David B Ascher, Tom L Blundell, Sony Malhotra
Mar 13, 2020
ABSTRACT In contrast to the situation with tuberculosis, rifampin resistance in leprosy may remain undetected due to the lack of rapid and effective diagnostic methods. A quick and reliable method is essential to determine the...
Brain Tissue Oxygen and Cerebrovascular Reactivity in Traumatic Brain Injury
Frederick A Zeiler, Erta Beqiri, Manuel Cabeleira, Peter J Hutchinson, Nino Stocchetti, David K Menon, Marek Czosnyka, Peter Smielewski, Ari Ercole, Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) High-Resolution ICU (HR ICU) Sub-Study Participants and Investigators
Mar 31, 2020
Pressure reactivity index (PRx) and brain tissue oxygen (PbtO2) are associated with outcome in traumatic brain injury (TBI). This study explores the relationship between PRx and PbtO2 in adult moderate/severe TBI. Using the...
ICP autoregulation brain tissue oxygen physiological burden Adult Aged Biomedical Research Brain Brain Injuries Traumatic Cerebrovascular Circulation Cohort Studies Cost of Illness Europe Female Glasgow Outcome Scale Humans Intersectoral Collaboration Male Middle Aged Oxygen Consumption Prospective Studies Treatment Outcome
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